Ibrutinib
|
- $5 - $1360
- Product name: Ibrutinib
- CAS: 936563-96-1
- MF: C25H24N6O2
- MW: 440.5
- EINECS:805-642-2
- MDL Number:MFCD20261150
- Synonyms:According to Lu imatinib;2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-;PCI-32765 (Ibrutinib);IBRUTINIB;1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one;1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one Ibrutinib (PCI32765);PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
84 prices
Selected condition：
Brand
- A1 Biochem Labs
- aablocks
- AccelPharmtech
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 1unit
- 10mM(in1mLDMSO)
- 1mg
- 200mg
- 10
- 20mg
- 500mg
- 2000mg
- 10mM*1mLinDMSO
- 1000mg
- EvaluationSample
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5G
- 10g
- 25g
- ManufacturerA1 Biochem Labs
- Product number6565111
- Product descriptionPCI-32765 95%
- Packaging5G
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerA1 Biochem Labs
- Product numberA1-01649
- Product descriptionPCI-32765 0.95
- Packaging5g
- Price$180
- Updated2026-06-05
- Buy
- Manufactureraablocks
- Product numberAA0035Z8
- Product description1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 98%
- Packaging25g
- Price$407
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035Z8
- Product description1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95%
- Packaging1g
- Price$26
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035Z8
- Product description1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95%
- Packaging5g
- Price$84
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035Z8
- Product description1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95%
- Packaging250mg
- Price$9
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035Z8
- Product description1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95%
- Packaging50mg
- Price$7
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035Z8
- Product description1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95%
- Packaging10mg
- Price$5
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberXF056410g
- Product descriptionIbrutinib 99%
- Packaging
- Price$208
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberXF0564
- Product descriptionIbrutinib 99%
- Packaging10g
- Price$208
- Updated2026-05-21
- Buy
- ManufacturerACHEMBLOCK
- Product number10243
- Product descriptionPCI-32765 98%
- Packaging25G
- Price$300
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10243
- Product descriptionPCI-32765 98%
- Packaging5G
- Price$105
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10243
- Product descriptionPCI-32765 98%
- Packaging1G
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3620-M005
- Product descriptionIbrutinib ≥98%(HPLC)
- Packaging5mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3620-M025
- Product descriptionIbrutinib ≥98%(HPLC)
- Packaging25mg
- Price$160
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberJ97283
- Product descriptionIbrutinib (PCI-32765) 95%
- Packaging5g
- Price$167
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6565111 | PCI-32765 95% | 5G | $180 | 2021-12-16 | Buy |
| A1 Biochem Labs | A1-01649 | PCI-32765 0.95 | 5g | $180 | 2026-06-05 | Buy |
| aablocks | AA0035Z8 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 98% | 25g | $407 | 2026-05-28 | Buy |
| aablocks | AA0035Z8 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95% | 1g | $26 | 2026-05-28 | Buy |
| aablocks | AA0035Z8 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95% | 5g | $84 | 2026-05-28 | Buy |
| aablocks | AA0035Z8 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95% | 250mg | $9 | 2026-05-28 | Buy |
| aablocks | AA0035Z8 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95% | 50mg | $7 | 2026-05-28 | Buy |
| aablocks | AA0035Z8 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one 95% | 10mg | $5 | 2026-05-28 | Buy |
| AccelPharmtech | XF056410g | Ibrutinib 99% | $208 | 2026-05-21 | Buy | |
| AccelPharmtech | XF0564 | Ibrutinib 99% | 10g | $208 | 2026-05-21 | Buy |
| ACHEMBLOCK | 10243 | PCI-32765 98% | 25G | $300 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10243 | PCI-32765 98% | 5G | $105 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10243 | PCI-32765 98% | 1G | $35 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3620-M005 | Ibrutinib ≥98%(HPLC) | 5mg | $80 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3620-M025 | Ibrutinib ≥98%(HPLC) | 25mg | $160 | 2026-05-06 | Buy |
| AK Scientific | J97283 | Ibrutinib (PCI-32765) 95% | 5g | $167 | 2026-06-04 | Buy |
Properties
Melting point :153-158°C
Boiling point :715.0±60.0 °C(Predicted)
Density :1.34
storage temp. :-20°C
solubility :Soluble in DMSO ( up to at least 25 mg/ml)
form :solid
pka :4.09±0.30(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :XYFPWWZEPKGCCK-GOSISDBHSA-N
SMILES :C(N1CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1)(=O)C=C
CAS DataBase Reference :936563-96-1
Boiling point :715.0±60.0 °C(Predicted)
Density :1.34
storage temp. :-20°C
solubility :Soluble in DMSO ( up to at least 25 mg/ml)
form :solid
pka :4.09±0.30(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :XYFPWWZEPKGCCK-GOSISDBHSA-N
SMILES :C(N1CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1)(=O)C=C
CAS DataBase Reference :936563-96-1
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||||||||||||||||||||
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Description
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation, promoting apoptosis and preventing homing to the protective tumor microenvironment, at concentrations that do not affect T cell receptor signaling (1,000-fold more potent). It has been reported to inhibit autophosphorylation of BTK (IC50 = 11 nM), phosphorylation of PLCγ (IC50 = 29 nM), a substrate of BTK, and phosphorylation of ERK (IC50 = 13 nM), a further downstream kinase. Its use has been examined clinically for the treatment of diseases associated with B cell antigen receptor signaling, including mantle cell lymphoma, chronic lymphocytic leukemia, and non-Hodgkin lymphoma.More related product prices
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Suppliers and manufacturers
Shanghai Mixiu Chemical Co., Ltd.
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Chongqing Chemieliva Pharmaceutical Co., Ltd.
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
Chembest Research Laboratories Limited