Ibrutinib
|
- $5 - $1208.7
- Product name: Ibrutinib
- CAS: 936563-96-1
- MF: C25H24N6O2
- MW: 440.5
- EINECS:805-642-2
- MDL Number:MFCD20261150
- Synonyms:According to Lu imatinib;2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-;PCI-32765 (Ibrutinib);IBRUTINIB;1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one;1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one Ibrutinib (PCI32765);PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
42 prices
Selected condition：
Brand
- A1 Biochem Labs
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
Package
- 1unit
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 10
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- 5G
- 10g
- ManufacturerA1 Biochem Labs
- Product number6565111
- Product descriptionPCI-32765 95%
- Packaging5G
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3620-M025
- Product descriptionIbrutinib ≥98%(HPLC)
- Packaging25mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ97283
- Product descriptionIbrutinib(PCI-32765)
- Packaging1g
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging5mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging10mg
- Price$7
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging50mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging100mg
- Price$15
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging250mg
- Price$21
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging1g
- Price$56
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging5g
- Price$254
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150396
- Product description(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+%
- Packaging10g
- Price$475
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3001
- Product descriptionPCI-32765(Ibrutinib)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60061
- Product descriptionIbrutinib(PCI-32765)
- Packaging20mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3371
- Product descriptionIbrutinib
- Packaging10mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3371
- Product descriptionIbrutinib
- Packaging25mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3371
- Product descriptionIbrutinib
- Packaging100mg
- Price$55
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A1 Biochem Labs | 6565111 | PCI-32765 95% | 5G | $180 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3620-M025 | Ibrutinib ≥98%(HPLC) | 25mg | $320 | 2021-12-16 | Buy |
| AK Scientific | J97283 | Ibrutinib(PCI-32765) | 1g | $90 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 5mg | $5 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 10mg | $7 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 50mg | $9 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 100mg | $15 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 250mg | $21 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 1g | $56 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 5g | $254 | 2021-12-16 | Buy |
| Ambeed | A150396 | (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one 98+% | 10g | $475 | 2021-12-16 | Buy |
| ApexBio Technology | A3001 | PCI-32765(Ibrutinib) | 1unit | $28 | 2021-12-16 | Buy |
| Arctom | CFN60061 | Ibrutinib(PCI-32765) | 20mg | $70 | 2021-12-16 | Buy |
| AvaChem | 3371 | Ibrutinib | 10mg | $35 | 2021-12-16 | Buy |
| AvaChem | 3371 | Ibrutinib | 25mg | $45 | 2021-12-16 | Buy |
| AvaChem | 3371 | Ibrutinib | 100mg | $55 | 2021-12-16 | Buy |
Properties
Melting point :153-158°C
Boiling point :715.0±60.0 °C(Predicted)
Density :1.34
storage temp. :-20°C
solubility :Soluble in DMSO ( up to at least 25 mg/ml)
form :solid
pka :4.09±0.30(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :XYFPWWZEPKGCCK-GOSISDBHSA-N
SMILES :C(N1CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1)(=O)C=C
CAS DataBase Reference :936563-96-1
Boiling point :715.0±60.0 °C(Predicted)
Density :1.34
storage temp. :-20°C
solubility :Soluble in DMSO ( up to at least 25 mg/ml)
form :solid
pka :4.09±0.30(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :XYFPWWZEPKGCCK-GOSISDBHSA-N
SMILES :C(N1CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1)(=O)C=C
CAS DataBase Reference :936563-96-1
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||||||||||||||||||||
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Description
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation, promoting apoptosis and preventing homing to the protective tumor microenvironment, at concentrations that do not affect T cell receptor signaling (1,000-fold more potent). It has been reported to inhibit autophosphorylation of BTK (IC50 = 11 nM), phosphorylation of PLCγ (IC50 = 29 nM), a substrate of BTK, and phosphorylation of ERK (IC50 = 13 nM), a further downstream kinase. Its use has been examined clinically for the treatment of diseases associated with B cell antigen receptor signaling, including mantle cell lymphoma, chronic lymphocytic leukemia, and non-Hodgkin lymphoma.More related product prices
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Suppliers and manufacturers
AFINE CHEMICALS LIMITED
SyncoZymes (Shanghai) Co., Ltd.,
