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ChemicalBook >> CAS DataBase List >> Ibrutinib

Ibrutinib

Ibrutinib price.
  • $29 - $653
  • Product name: Ibrutinib
  • CAS: 936563-96-1
  • MF: C25H24N6O2
  • MW: 440.5
  • EINECS:805-642-2
  • MDL Number:MFCD20261150
  • Synonyms:(R)-1-(3-(4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidin-1-yl)prop-2-en-1-one;1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one;Ibrutinib (PCI-32765);1-{3-[4-AMino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyriMidin-1-yl]-piperidin-1-yl}-propenone;1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one Ibrutinib (PCI32765);Factory supply high quality Ibrutinib Cas 936563-96-1 with best price and fast delivery;N6-(2-Carboxyethyl) 
4 prices
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Brand

  • Cayman Chemical

Package

  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • ManufacturerCayman Chemical
  • Product number16274
  • Product descriptionIbrutinib ≥98%
  • Packaging1mg
  • Price$29
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number16274
  • Product descriptionIbrutinib ≥98%
  • Packaging5mg
  • Price$87
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number16274
  • Product descriptionIbrutinib ≥98%
  • Packaging10mg
  • Price$145
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number16274
  • Product descriptionIbrutinib ≥98%
  • Packaging50mg
  • Price$653
  • Updated2018-11-13
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 16274 Ibrutinib ≥98% 1mg $29 2018-11-13 Buy
Cayman Chemical 16274 Ibrutinib ≥98% 5mg $87 2018-11-13 Buy
Cayman Chemical 16274 Ibrutinib ≥98% 10mg $145 2018-11-13 Buy
Cayman Chemical 16274 Ibrutinib ≥98% 50mg $653 2018-11-13 Buy

Properties

Boiling point: :715.0±60.0 °C(Predicted)
Density  :1.34
pka :4.09±0.30(Predicted)
CAS DataBase Reference :936563-96-1

Safety Information

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Description

Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation, promoting apoptosis and preventing homing to the protective tumor microenvironment, at concentrations that do not affect T cell receptor signaling (1,000-fold more potent). It has been reported to inhibit autophosphorylation of BTK (IC50 = 11 nM), phosphorylation of PLCγ (IC50 = 29 nM), a substrate of BTK, and phosphorylation of ERK (IC50 = 13 nM), a further downstream kinase. Its use has been examined clinically for the treatment of diseases associated with B cell antigen receptor signaling, including mantle cell lymphoma, chronic lymphocytic leukemia, and non-Hodgkin lymphoma.

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