Penicillins drugs

Mechanism
penicillin can inhibit the synthesis of bacterial cell wall, leading to the production and activation of autolysis enzymes, resulting in bacterial death. For this group of drugs, different varieties target on different penicillin-binding proteins and enzymes with these proteins and enzymes being involved in bacterial cell wall metabolism.

Indications
they have bactericidal effect during the reproduction period of bacteria. Gram-positive cocci: Streptococcus, pneumococcus, sensitive staphylococcus; and some kinds of gram-negative cocci: to Neisseria meningitidis, Neisseria gonorrhoeae, they have strong antibacterial effects. Clostridium bacilli: Corynebacterium diphtheriae; spirochete, Treponema pallidum, borrelia recurrentis, and Leptospira; they are also applicable to various kinds of inflection diseases caused by Clostridium bacillus, Tetanus bacilli, Clostridium welchii and actinomycetes; for example, various kinds of suppurative skin disease, skin bacterial infections, gonorrhea, syphilis and so on.

Contraindications
patients who are allergic to penicillin and have a history of allergy should be disabled.

Adverse reactions
1. Allergic reaction
2. Gastrointestinal discomfort.

Precautions
1. Probenecid can block the excretion of penicillin drugs with combination usage can cause the increase of its plasma concentration.
2. Before drug administration, people must be subject to skin test according to the provisions. Patients who are allergic to the procaine should be disabled from using the procaine penicillin.
3. Procaine penicillin can occasionally cause a specific reaction. Upon injection of drugs or after 1 ~2min, patients may get a series of symptoms such as feeling uncomfortable in the heart, getting endangered fear, dizziness, palpitations and auditory hallucinations. Generally there are no breathing disorders and circulatory disorders occurring. For the majority of cases can be elevated blood pressure. Generally this doesn’t require special treatment. The symptoms will be automatically relived after 1 ~ 2h. Application of sedatives and antihistamines can help to restore.
4. Low-dose of penicillin does not cause toxicity. Large doses of application may cause neuropsychiatric symptoms. For patients with hemagglutination defects, high-dose of penicillin can disrupt the blood clotting mechanism, thereby leading to bleeding tendency.
5. The aqueous solution of penicillin sodium and potassium salt are unstable, thus should be used now with.

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Structure Chemical Name CAS MF
Ampicillin Ampicillin 7177-48-2 C16H25N3O7S
WORTMANNIN WORTMANNIN 19545-26-7 C23H24O8
Oxacillin sodium monohydrate Oxacillin sodium monohydrate 7240-38-2 C19H18N3NaO5S
Ampicillin sodium Ampicillin sodium 69-52-3 C16H18N3NaO4S
Procaine penicilline G hydrate Procaine penicilline G hydrate 6130-64-9 C29H38N4O6S
Penicillin V-D5 Penicillin V-D5 C16H18N2O5S
AMOXICILLIN AND CLAVULANATE POTASSIUM AMOXICILLIN AND CLAVULANATE POTASSIUM
Penicillin G sodium salt Penicillin G sodium salt 69-57-8 C16H17N2NaO4S
Sodium cloxacillin monohydrate Sodium cloxacillin monohydrate 7081-44-9 C19H19ClN3NaO6S
Carbenicillin disodium Carbenicillin disodium 4800-94-6 C17H19N2NaO6S
Piperacillin sodium salt Piperacillin sodium salt 59703-84-3 C23H26N5NaO7S
Cloxacillin benzathine Cloxacillin benzathine 23736-58-5 C35H37ClN5NaO5S
PENICILLINASE PENICILLINASE 9001-74-5
Ampicillin Ampicillin 69-53-4 C16H19N3O4S
Amoxicillin Amoxicillin 26787-78-0 C16H19N3O5S
Potassium benzylpenicillin Potassium benzylpenicillin 113-98-4 C16H17KN2O4S
LENAMPICILLIN LENAMPICILLIN 86273-18-9 C21H23N3O7S
Azlocillin sodium Azlocillin sodium 37091-65-9 C20H22N5NaO6S
Pipracil Pipracil 61477-96-1 C23H27N5O7S
OXACILLIN OXACILLIN 66-79-5 C19H19N3O5S
CARBENICILLIN CARBENICILLIN 4697-36-3 C17H18N2O6S
Benzathine benzylpenicillin Benzathine benzylpenicillin 1538-09-6 C48H56N6O8S2
Flucloxacillin sodium Flucloxacillin sodium 1847-24-1 C19H16ClFN3NaO5S
Procaine penicillin G Procaine penicillin G 54-35-3 C29H38N4O6S
MAGNAMYCIN A PENICILLIN G MAGNAMYCIN A PENICILLIN G
Penicillin G Penicillin G 61-33-6 C16H18N2O4S
CHLOMETHOCILLIN CHLOMETHOCILLIN 1926-49-4 C17H18Cl2N2O5S
Penicillin V potassium salt Penicillin V potassium salt 132-98-9 C16H17KN2O5S
TALAMPICILLIN TALAMPICILLIN 47747-56-8 C24H23N3O6S
Penicillin V Benzathine Penicillin V Benzathine 63690-57-3 C16H20N2.2C16H18N2O5S
CARBENICILLIN PHENYL SODIUM CARBENICILLIN PHENYL SODIUM 27025-49-6 C23H22N2O6S
PENICILLIN-STREPTOMYCIN-NEOMYCIN PENICILLIN-STREPTOMYCIN-NEOMYCIN C61H105N15O30S
Amoxicillin sodium Amoxicillin sodium 34642-77-8 C16H19N3NaO5S
Mezlocillin sodium Mezlocillin sodium 59798-30-0 C21H24N5NaO8S2
Dicloxacillin sodium Dicloxacillin sodium 13412-64-1 C19H16Cl2N3NaO5S·H2O
Methicillin Sodium Salt Methicillin Sodium Salt 132-92-3 C17H19N2NaO6S
Penicillin G mixture Penicillin G mixture
PENICILLIN V POTASSIUM USP(CRM STANDARD) PENICILLIN V POTASSIUM USP(CRM STANDARD)
PENCILLIN G SODIUM USP(CRM STANDARD) PENCILLIN G SODIUM USP(CRM STANDARD)
L-PHENETHICILLIN POTASSIUM USP(CRM STANDARD) L-PHENETHICILLIN POTASSIUM USP(CRM STANDARD)
METHICILLIN SODIUM (500 MG) (AS) METHICILLIN SODIUM (500 MG) (AS) 7246-14-2 C17H21N2NaO7S
Sulbenicillin sodium Sulbenicillin sodium 28002-18-8 C16H16N2Na2O7S2
OXACILLIN SODIUM OXACILLIN SODIUM 1173-88-2 C19H18N3NaO5S
Azlocillin Azlocillin 37091-66-0 C20H23N5O6S
Dicloxacillin Dicloxacillin 3116-76-5 C19H17Cl2N3O5S
EC 3.5.1.11 EC 3.5.1.11 9014-06-6
APALCILLIN APALCILLIN 63469-19-2 C25H23N5O6S
Mecillinam Mecillinam 32887-01-7 C15H23N3O3S
Ticarcillin Ticarcillin 34787-01-4 C15H16N2O6S2
N-4-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE N-4-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE 265989-30-8 C19H21NO3
Flucloxacillin Flucloxacillin 5250-39-5 C19H17ClFN3O5S
Nafcillin sodium salt monohydrate Nafcillin sodium salt monohydrate 7177-50-6 C21H23N2NaO6S
Mezlocillin Mezlocillin 51481-65-3 C21H25N5O8S2
LK-PENICILLIN IN PENICILLIN G THE DERIVATIVES LK-PENICILLIN IN PENICILLIN G THE DERIVATIVES 30034-13-0 C24H26N2O6S
D-PHENETHICILLIN POTASSIUM USP(CRM STANDARD) D-PHENETHICILLIN POTASSIUM USP(CRM STANDARD)
TICARCILLIN DISODIUM SALT TICARCILLIN DISODIUM SALT 29457-07-6 C15H14N2Na2O6S2
7-(2,2-DIMETHYL-5-OXO-4-PHENYL-IMIDAZOLIDIN-1-YL)-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID 7-(2,2-DIMETHYL-5-OXO-4-PHENYL-IMIDAZOLIDIN-1-YL)-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID 3511-16-8 C19H23N3O4S
Procaine penicillin G(fortified) Procaine penicillin G(fortified)
TALAMPICILLIN HYDROCHLORIDE EPT(CRM STANDARD) TALAMPICILLIN HYDROCHLORIDE EPT(CRM STANDARD)
METICILLIN SODIUM WHO(CRM STANDARD) METICILLIN SODIUM WHO(CRM STANDARD)
BACAMPICILLIN BACAMPICILLIN 50972-17-3 C21H27N3O7S
Aspoxicillin Aspoxicillin 63358-49-6 C21H27N5O7S
CYCLACILLIN (200  MG) CYCLACILLIN (200 MG) 3485-14-1 C15H23N3O4S
Penicillin G sodium buffered Penicillin G sodium buffered
PENICILLIN G BENZATHINE USP(CRM STANDARD) PENICILLIN G BENZATHINE USP(CRM STANDARD)
AZLOCILLIN SODIUM USP(CRM STANDARD) AZLOCILLIN SODIUM USP(CRM STANDARD)
BENETHAMINE PENICILLIN BP(CRM STANDARD) BENETHAMINE PENICILLIN BP(CRM STANDARD)
BENZYLPENICILLIN BENZATHINE IMP. B (EP): PHENYLACETIC ACID GÜ BENZYLPENICILLIN BENZATHINE IMP. B (EP): PHENYLACETIC ACID GÜ
CLOXACILLIN BENZATHINE USP(CRM STANDARD) CLOXACILLIN BENZATHINE USP(CRM STANDARD)
PHENETHICILLIN POTASSIUM SALT PHENETHICILLIN POTASSIUM SALT 132-93-4 C17H19KN2O5S
FLUCLOXACILLIN SODIUM EPF(CRM STANDARD) FLUCLOXACILLIN SODIUM EPF(CRM STANDARD)
BACAMPICILLIN HYDROCHLORIDE BACAMPICILLIN HYDROCHLORIDE 37661-08-8 C21H28ClN3O7S
Penicillin G procaine/Potassium 3:1 Penicillin G procaine/Potassium 3:1
Penicillin G potassium,non sterile Penicillin G potassium,non sterile
BENZATHINE BENZYLPENICILLIN EPB(CRM STANDARD) BENZATHINE BENZYLPENICILLIN EPB(CRM STANDARD)
4-HYDROXY PHENOXYMETHYLPENICILLIN EPH(CRM STANDARD) 4-HYDROXY PHENOXYMETHYLPENICILLIN EPH(CRM STANDARD)
PIVMECILLINAM HYDROCHLORIDE EPP(CRM STANDARD) PIVMECILLINAM HYDROCHLORIDE EPP(CRM STANDARD)
BENETHAMINE PENICILLIN BENETHAMINE PENICILLIN
TICARCILLIN SODIUM EPT(CRM STANDARD) TICARCILLIN SODIUM EPT(CRM STANDARD)
Penicillin&StreptoMycin&NeoMycin solution,γ-Irradiated Penicillin&StreptoMycin&NeoMycin solution,γ-Irradiated
PENICILLIN V PENICILLIN V 87-08-1 C16H18N2O5S
PENICILLIN G ALLERGY REAGENTS PENICILLIN G ALLERGY REAGENTS
AMOXYCILLIN Sodium sterile IP/Bp AMOXYCILLIN Sodium sterile IP/Bp
PENICILLIN G PROCAINE USP(CRM STANDARD) PENICILLIN G PROCAINE USP(CRM STANDARD)
PHENOXYMETHYLPENICILLIN POTASSIUM IMP. B (EP): PHENOXYACETIC ACID MM(CRM STANDARD) PHENOXYMETHYLPENICILLIN POTASSIUM IMP. B (EP): PHENOXYACETIC ACID MM(CRM STANDARD)
NAFCILLIN SODIUM SALT NAFCILLIN SODIUM SALT 985-16-0 C21H21N2NaO5S
SULBENICILLIN SULBENICILLIN 41744-40-5 C16H18N2O7S2
almecillin almecillin 87-09-2 C13H18N2O4S2
Carbenicillin Disodium Salt Carbenicillin Disodium Salt
PENICILLIN V USP(CRM STANDARD) PENICILLIN V USP(CRM STANDARD)
PHENOXYMETHYLPENICILLIN POTASSIUM IMP. E (EP): PHENOXYMETHYLPENICILLOIC ACID MM(CRM STANDARD) PHENOXYMETHYLPENICILLIN POTASSIUM IMP. E (EP): PHENOXYMETHYLPENICILLOIC ACID MM(CRM STANDARD)
Penicillin G benzathine buffered Penicillin G benzathine buffered
Penicillin G Procaine/Sodium 3:1 Penicillin G Procaine/Sodium 3:1
PENICILLIN STREPTOMYCIN PENICILLIN STREPTOMYCIN "GAMMA" IRRADIATED TISSUE CULTURE GRADE
BENZYLPENICILLIN POTASSIUM IMP.E (EP):PENICILLOIC ACIDS OF BENZYLPENICILLIN MM(CRM STANDARD) BENZYLPENICILLIN POTASSIUM IMP.E (EP):PENICILLOIC ACIDS OF BENZYLPENICILLIN MM(CRM STANDARD)
pheneticillin pheneticillin 147-55-7 C17H20N2O5S
Penicillin G Sodium salt Penicillin G Sodium salt
CYCLACILLIN USP(CRM STANDARD) CYCLACILLIN USP(CRM STANDARD)
FURBENCILLIN SODIUM FURBENCILLIN SODIUM
Penicillin&StreptoMycin solution,γ-Irradiated Penicillin&StreptoMycin solution,γ-Irradiated
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