Sulfonamides and synergist

Sulfa drugs developed rapidly in the 1930s, and there had been more than 20 species of the drugs for the clinical application. the status of sulfa drugs in chemotherapeutic agents declined after 1940s due to the occurrence of penicillin and other antibiotics. But sulfa drugs, whose  antibacterial activity will be enhanced when combined with trimethoprim the antibacterial synergist, are still commonly used antibacterial drugs for the advantages of broad antibacterial spectrum, enabled to be administered orally, more rapid absorption. Clarifying the mechanism of the action of sulfa drugs established anti-metabolic theory and opened up a new way for the development of new drugs. Currently there are sulfadiazine and sulfamethoxazole that are used most widely in clinical.

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Structure Chemical Name CAS MF
(S)-(-)-2-Methyl-2-propanesulfinamide (S)-(-)-2-Methyl-2-propanesulfinamide 343338-28-3 C4H11NOS
3-(METHYLSULFONYLAMINO)PHENYLBORONIC ACID 3-(METHYLSULFONYLAMINO)PHENYLBORONIC ACID 148355-75-3 C7H10BNO4S
3-Aminobenzenesulfonamide 3-Aminobenzenesulfonamide 98-18-0 C6H8N2O2S
2-(Methanesulfonylamino)phenylboronic acid 2-(Methanesulfonylamino)phenylboronic acid 756520-78-2 C7H10BNO4S
3-CARBOXYPROPANESULFONAMIDE 3-CARBOXYPROPANESULFONAMIDE 175476-52-5 C4H9NO4S
Trimethoprim Trimethoprim 738-70-5 C14H18N4O3
(R)-(+)-2-Methyl-2-propanesulfinamide (R)-(+)-2-Methyl-2-propanesulfinamide 196929-78-9 C4H11NOS
2-Bromobenzenesulphonyl chloride 2-Bromobenzenesulphonyl chloride 2905-25-1 C6H4BrClO2S
4-(METHYLSULFONYLAMINO)PHENYLBORONIC ACID 4-(METHYLSULFONYLAMINO)PHENYLBORONIC ACID 380430-57-9 C7H10BNO4S
3-BROMOBENZENESULFONAMIDE 3-BROMOBENZENESULFONAMIDE 89599-01-9 C6H6BrNO2S
4-Bromobenzenesulfonamide 4-Bromobenzenesulfonamide 701-34-8 C6H6BrNO2S
Sulfadiazine Sulfadiazine 68-35-9 C10H10N4O2S
Silver sulfadiazine Silver sulfadiazine 22199-08-2 C10H9AgN4O2S
2-(N,N-Dimethylsulphamoyl)phenylboronic acid 2-(N,N-Dimethylsulphamoyl)phenylboronic acid 178432-25-2 C8H12BNO4S
3-NITROBENZENESULFONAMIDE 3-NITROBENZENESULFONAMIDE 121-52-8 C6H6N2O4S
Sulfanilamide Sulfanilamide 63-74-1 C6H8N2O2S
Sulfamethoxazole Sulfamethoxazole 723-46-6 C10H11N3O3S
3-Cyanophenylboronic acid 3-Cyanophenylboronic acid 150255-96-2 C7H6BNO2
Sulfasalazine Sulfasalazine 599-79-1 C18H14N4O5S
Sulfamerazine Sulfamerazine 127-79-7 C11H12N4O2S
Sulfacetamide sodium Sulfacetamide sodium 127-56-0 C8H9N2NaO3S
Sulfamethoxypyridazine Sulfamethoxypyridazine 80-35-3 C11H12N4O3S
3-BROMO-N-TERT-BUTYLBENZENESULPHONAMIDE 3-BROMO-N-TERT-BUTYLBENZENESULPHONAMIDE 308283-47-8 C10H14BrNO2S
Sulfamonomethoxine sodium Sulfamonomethoxine sodium C11H11N4NaO3S
2-(Morpholinosulfonyl)phenylboronic acid 2-(Morpholinosulfonyl)phenylboronic acid 957062-65-6 C10H14BNO5S
2-METHANESULFONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER 2-METHANESULFONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER 380430-60-4 C13H20BNO4S
Sulfamethazine sodium salt Sulfamethazine sodium salt 1981-58-4 C12H15N4NaO2S
4-(Aminosulfonyl)phenylboronic acid 4-(Aminosulfonyl)phenylboronic acid 613660-87-0 C6H8BNO4S
Phthalylsulfathiazole Phthalylsulfathiazole 85-73-4 C17H13N3O5S2
3-AMINO-N,N-DIETHYL-BENZENESULFONAMIDE 3-AMINO-N,N-DIETHYL-BENZENESULFONAMIDE 10372-41-5 C10H16N2O2S
Mafenide hydrochloride Mafenide hydrochloride 138-37-4 C7H11ClN2O2S
N-T-BUTYL 3-NITROBENZENESULFONAMIDE N-T-BUTYL 3-NITROBENZENESULFONAMIDE 424818-25-7 C10H14N2O4S
Succinylsulfathiazole Succinylsulfathiazole 116-43-8 C13H13N3O5S2
(4-METHANESULFONYLAMINOMETHYL)PHENYL BORONIC ACID (4-METHANESULFONYLAMINOMETHYL)PHENYL BORONIC ACID 850568-38-6 C8H12BNO4S
Policresulen Policresulen 9011-02-3 (C15H16O8S2)n
2-(PYRROLIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID 97 2-(PYRROLIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID 97 913835-83-3 C10H14BNO4S
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE 78162-58-0 C5H9N3O2S
P-CHLOROSULFONYLDIHYDROCINNAMIC ACID P-CHLOROSULFONYLDIHYDROCINNAMIC ACID 63545-54-0 C9H9ClO4S
Sulfacetamide Sulfacetamide 144-80-9 C8H10N2O3S
SULFAMETHIZOLE SULFAMETHIZOLE 144-82-1 C9H10N4O2S2
3-(PIPERIDINOSULFONYL)ANILINE 3-(PIPERIDINOSULFONYL)ANILINE 22184-99-2 C11H16N2O2S
3-(1-PYRROLIDINYLSULFONYL)ANILINE 3-(1-PYRROLIDINYLSULFONYL)ANILINE 91619-38-4 C10H14N2O2S
Sulfadimethoxine sodium salt  Sulfadimethoxine sodium salt 1037-50-9 C12H13N4NaO4S
3-AMINO-N-CYCLOPROPYLBENZENESULFONAMIDE 3-AMINO-N-CYCLOPROPYLBENZENESULFONAMIDE 459434-39-0 C9H12N2O2S
Sodium sulfadiazine Sodium sulfadiazine 547-32-0 C10H9N4NaO2S
(3-AMINOSULPHONYL)BENZENEBORONIC ACID (3-AMINOSULPHONYL)BENZENEBORONIC ACID 850568-74-0 C6H8BNO4S
Sulfathiazole Sulfathiazole 72-14-0 C9H9N3O2S2
Sulfaguanidine Sulfaguanidine 57-67-0 C7H10N4O2S
Sulfadimethoxine Sulfadimethoxine 122-11-2 C12H14N4O4S
3-(MORPHOLINOSULFONYL)ANILINE 3-(MORPHOLINOSULFONYL)ANILINE 22184-97-0 C10H14N2O3S
Sulfamethazine Sulfamethazine 57-68-1 C12H14N4O2S
N,N-DIMETHYL 4-IODO-1H-IMIDAZOLE-1-SULFONAMIDE N,N-DIMETHYL 4-IODO-1H-IMIDAZOLE-1-SULFONAMIDE 135773-25-0 C5H8IN3O2S
4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE 4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE 707-60-8 C8H10BrNO2S
4-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID 4-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID 486422-59-7 C8H12BNO4S
3-BROMO-N-ETHYLBENZENESULPHONAMIDE 3-BROMO-N-ETHYLBENZENESULPHONAMIDE 871269-07-7 C8H10BrNO2S
3-BROMO-N-METHYLBENZENESULPHONAMIDE 3-BROMO-N-METHYLBENZENESULPHONAMIDE 153435-79-1 C7H8BrNO2S
4-BROMO-N-ETHYLBENZENESULPHONAMIDE 4-BROMO-N-ETHYLBENZENESULPHONAMIDE 1984-25-4 C8H10BrNO2S
1-(4-BROMOPHENYLSULFONYL)PYRROLIDINE 1-(4-BROMOPHENYLSULFONYL)PYRROLIDINE 136350-52-2 C10H12BrNO2S
3-(Piperidin-1-ylsulphonyl)pyridine 3-(Piperidin-1-ylsulphonyl)pyridine 26103-49-1 C10H14N2O2S
2-Bromo-N,N-dimethylbenzenesulphonamide 2-Bromo-N,N-dimethylbenzenesulphonamide 65000-13-7 C8H10BrNO2S
5-Bromo-N,N-diethylpyridine-3-sulphonamide 5-Bromo-N,N-diethylpyridine-3-sulphonamide 62009-37-4 C9H13BrN2O2S
2-Bromo-N-ethylbenzenesulphonamide 2-Bromo-N-ethylbenzenesulphonamide 169189-80-4 C8H10BrNO2S
Sulfathiazole sodium Sulfathiazole sodium 144-74-1 C9H10N3NaO2S2
N-BENZYL 5-BROMO-2-METHOXYBENZENESULFONAMIDE N-BENZYL 5-BROMO-2-METHOXYBENZENESULFONAMIDE 446308-82-3 C14H14BrNO3S
2-([(4-BROMOPHENYL)SULFONYL]AMINO)ACETIC ACID 2-([(4-BROMOPHENYL)SULFONYL]AMINO)ACETIC ACID 13029-73-7 C8H8BrNO4S
4-BROMO-N-METHYL-BENZENESULFONAMIDE 4-BROMO-N-METHYL-BENZENESULFONAMIDE 703-12-8 C7H8BrNO2S
3-BROMO-N-PYRROLIDIN-1-YLBENZENESULPHONAMIDE 3-BROMO-N-PYRROLIDIN-1-YLBENZENESULPHONAMIDE 214210-14-7 C10H12BrNO2S
3-(N-MORPHOLINYLSULPHONAMIDO)BENZENEBORONIC ACID 3-(N-MORPHOLINYLSULPHONAMIDO)BENZENEBORONIC ACID 871329-60-1 C10H14BNO5S
(4-METHYLAMINOSULPHONYL)BENZENE BORONIC ACID (4-METHYLAMINOSULPHONYL)BENZENE BORONIC ACID 226396-31-2 C7H10BNO4S
SULFISOMIDINE SULFISOMIDINE 515-64-0 C12H14N4O2S
N-BENZYL 3-BROMO-4-METHYLBENZENESULFONAMIDE N-BENZYL 3-BROMO-4-METHYLBENZENESULFONAMIDE 850429-67-3 C14H14BrNO2S
4-METHOXY-3-(PIPERIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID 4-METHOXY-3-(PIPERIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID 874219-18-8 C12H18BNO5S
N,N-DIMETHYL 4,5-DIIODO-1H-IMIDAZOLE-1-SULFONAMIDE N,N-DIMETHYL 4,5-DIIODO-1H-IMIDAZOLE-1-SULFONAMIDE 198127-92-3 C5H7I2N3O2S
2-Bromo-N-(4-fluoroBenzyl)Benzenesulphonamide 2-Bromo-N-(4-fluoroBenzyl)Benzenesulphonamide 321705-40-2 C13H11BrFNO2S
4-(N-BUTYLSULPHONAMIDO)BENZENEBORONIC ACID 4-(N-BUTYLSULPHONAMIDO)BENZENEBORONIC ACID 850589-32-1 C10H16BNO4S
1-(4-BROMOPHENYLSULFONYL)PIPERIDINE 1-(4-BROMOPHENYLSULFONYL)PIPERIDINE 834-66-2 C11H14BrNO2S
3-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID 3-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID 871329-59-8 C8H12BNO4S
4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide 4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide 329939-43-7 C14H14BrNO3S
4-(N,N-DIETHYLSULPHONAMIDO)BENZENEBORONIC ACID 4-(N,N-DIETHYLSULPHONAMIDO)BENZENEBORONIC ACID 850568-76-2 C10H16BNO4S
Sulfabenzamide Sulfabenzamide 127-71-9 C13H12N2O3S
4-(TERT-BUTYLAMINOSULPHONYL)BENZENEBORONIC ACID 4-(TERT-BUTYLAMINOSULPHONYL)BENZENEBORONIC ACID 208516-15-8 C10H16BNO4S
4-(AMINOMETHYL)BENZENESULFONAMIDE 4-(AMINOMETHYL)BENZENESULFONAMIDE 138-39-6 C7H10N2O2S
N-(2-AMINOETHYL) 4-BROMOBENZENESULFONAMIDE N-(2-AMINOETHYL) 4-BROMOBENZENESULFONAMIDE 90002-56-5 C8H11BrN2O2S
1,4-BUTANESULTAM 1,4-BUTANESULTAM 37441-50-2 C4H9NO2S
Mafenide acetate Mafenide acetate 13009-99-9 C9H14N2O4S
4-BROMO-N-(3-CHLOROPROPYL)BENZENESULPHONAMIDE 4-BROMO-N-(3-CHLOROPROPYL)BENZENESULPHONAMIDE 98768-71-9 C9H11BrClNO2S
2-Bromo-N-(tert-butyl)benzenesulphonamide 2-Bromo-N-(tert-butyl)benzenesulphonamide 138733-50-3 C10H14BrNO2S
4-Bromo-N-butylbenzamide 4-Bromo-N-butylbenzamide 78080-34-9 C11H14BrNO
N-Isopropyl 2-bromobenzenesulfonamide N-Isopropyl 2-bromobenzenesulfonamide 951883-94-6 C9H12BrNO2S
4-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 4-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 331950-30-2 C9H10BrNO2S
2-METHYL-5-(N-MORPHOLINYLSULFONYL)PHENYLBORONIC ACID 2-METHYL-5-(N-MORPHOLINYLSULFONYL)PHENYLBORONIC ACID 871329-74-7 C11H16BNO5S
(3-METHANESULFONYLAMINOMETHYL)BENZENEBORONIC ACID (3-METHANESULFONYLAMINOMETHYL)BENZENEBORONIC ACID 850568-39-7 C8H12BNO4S
3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE 3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE 608523-94-0 C10H16N2O2S
Sulfamonomethoxine Sulfamonomethoxine 1220-83-3 C11H12N4O3S
2-(N,N-diethylsulfamoyl)phenylboronic acid 2-(N,N-diethylsulfamoyl)phenylboronic acid 957061-16-4 C10H16BNO4S
3-(PYRROLIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 3-(PYRROLIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 871329-61-2 C10H14BNO4S
4-(N-ISOPROPYLSULFAMOYL)PHENYLBORONIC ACID 4-(N-ISOPROPYLSULFAMOYL)PHENYLBORONIC ACID 850589-31-0 C9H14BNO4S
3-AMINO-N-METHYLBENZENESULFONAMIDE 3-AMINO-N-METHYLBENZENESULFONAMIDE 459434-40-3 C7H10N2O2S
4-(N-CYCLOPROPYLSULPHONAMIDO)BENZENEBORONIC ACID 4-(N-CYCLOPROPYLSULPHONAMIDO)BENZENEBORONIC ACID 871329-67-8 C9H12BNO4S
3-(N-CYCLOPROPYLSULPHAMOYL)BENZENEBORONIC ACID 98 3-(N-CYCLOPROPYLSULPHAMOYL)BENZENEBORONIC ACID 98 913835-28-6 C9H12BNO4S
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