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Sofalcone

Sofalcone Suppliers list
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Sofalcone
CAS:64506-49-6
Purity:98% Package:1KG;1USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:Sofalcone
CAS:64506-49-6
Purity:99% Package:5KG;1KG
Company Name: hdzhl biotechnology co., ltd
Tel: 86-13032617415
Email: sales@luchibiology.com
Products Intro: Product Name:Sofalcone
CAS:64506-49-6
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Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
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Products Intro: Product Name:Sofalcone
CAS:64506-49-6
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-18612256290
Email: 1010@dideu.com
Products Intro: Product Name:Sofalcone
CAS:64506-49-6
Purity:99% Package:1g;1USD|10g;1USD|100g;1USD|1Kg/Bag;1USD|10Kg/Bag;1USD

Lastest Price from Sofalcone manufacturers

  • Sofalcone
  • US $1.00-1.00 / Kg/Bag
  • 2020-05-12
  • CAS:64506-49-6
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Sofalcone
  • US $0.00-0.00 / KG
  • 2019-09-11
  • CAS:64506-49-6
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 800 kg
  • Sofalcone
  • US $1.00 / KG
  • 2019-07-06
  • CAS:64506-49-6
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 100KG
Sofalcone Basic information
Pharmacological action Pharmacokinetics
Product Name:Sofalcone
Synonyms:{5-[(3-methyl-2-butenyl)oxy]-2-{p-[(3-methyl-2-butenyl)oxy]cinnamoyl}phenoxy}acetic acid;SOFALCONE;SOFALCONE(2'-ETHOXYCARBONYLMETHOXY-4'-(3-METHYL-2-BUTENYL-OXY)ACETOPHENONE);SOFALCONE JP;SOFALCONE MICROPOWDER;[4,4'-Bis(3-methyl-2-butenyloxy)chalcon-2'-yloxy]acetic acid;[5-[(3-Methyl-2-butenyl)oxy]-2-[3-[4-[(3-methyl-2-butenyl)oxy]phenyl]-1-oxo-2-propenyl]phenoxy]acetic acid;2-[5-[(3-Methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-Methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]acetic Acid
CAS:64506-49-6
MF:C27H30O6
MW:450.52
EINECS:1308068-626-2
Product Categories:
Mol File:64506-49-6.mol
Sofalcone Structure
Sofalcone Chemical Properties
Melting point 143-144°
Boiling point 478.6°C (rough estimate)
density 1.1362 (rough estimate)
refractive index 1.4870 (estimate)
pka2.98±0.10(Predicted)
CAS DataBase Reference64506-49-6(CAS DataBase Reference)
Safety Information
ToxicityLD50 in mice, rats: >10 g/kg orally (Tarumoto)
MSDS Information
Sofalcone Usage And Synthesis
Pharmacological actionSofalcone is an effective component extracted and synthesized from traditional Chinese medicine Sophora tonkinensis. It is the product of isoprene derivatives. It can increase gastric blood flow, expand gastric mucosal blood vessels, increase oxygen consumption in gastric tissue, promote gastric mucosal repair, increase gastric wall composition and increase prostaglandin content in gastric tissue. Its mechanism is to inhibit prostaglandin 5hydroxyl prostaglandin dehydrogenase (PG). This product has a good effect on the ulcer of the digestive tract by enhancing the defense factor. It is mainly used for the treatment of gastric ulcer and gastritis.

Figure 1 Structural formula for sofalcone
PharmacokineticsThis product is absorbed quickly after oral administration, and the concentration is up to the peak in about one hour. The half life of plasma is about 1h, and it will almost disappear in the blood after 2h. The main metabolites in the body are the reductive products of the alpha and beta unsaturated bonds of the chalcone skeleton, and the oxidation products of the isoprene side chain. It is excreted from urine by 6% to 8% in the form of isoprene chain oxidation products within 48h.
DescriptionSofalcone is a synthetic antiulcer agent related to sophoradin, the active principle of the Chinese medicinal plant, Sophora subprostata. It is suggested to act via a strengthening of the mucosal barrier through an increase in blood flow and stimulation of the synthesis of sulfated mucopolysaccharides.
OriginatorJapan (Japan)
UsesSofalcone is a substituted chalcone with anti-ulcer activity.
UsesSofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM. Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.[Cayman Chemical]
Sofalcone Preparation Products And Raw materials
Tag:Sofalcone(64506-49-6) Related Product Information
trans-Chalcone Tris Base Methanol Bensulfuron methyl Methylparaben 2-Hydroxyethyl methacrylate 1-[2-HYDROXY-4-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-ETHANONE 4'-(3-Methyl-2-butyenyloxy)benzaldehyde Sofalcone Desogestrel METSULFURON METHYL Methyl cellulose Methyl Kresoxim-methyl Methyl bromide CARBOXYMETHYLCELLULOSE SODIUM SALT methylol cellulose Trimethylolpropane