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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:1-Phenyl-3-methyl-2-pyrazolin-5-on
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:89-25-8
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Anhui Royal Chemical Co., Ltd.
Tel: +86-025-86655873
Products Intro: Product Name:5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Products Intro: Product Name:1-Phenyl-3-Methyl-5-Pyrazolone (PMP)
Purity:99.5 Package:1kg;1USD

Lastest Price from 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one manufacturers

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Basic information
Product Name:5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Synonyms:TIMTEC-BB SBB003801;PMP;MONOPYRAZOLONE;2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-on;2-Pyrazolin-5-one, 3-methyl-1-phenyl-;3H-Pyrazol-3-one,2,4-dihydro-5-methyl-;3-methyl-1-phenyl-2-pyrazolin-5-on;3-methyl-1-phenyl-5-pyrazolon
Product Categories:heteroXlink;Cardiovascular APIs;Pharmaceutical intermediates;Aromatices;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API;Aromatics Compounds;ChromophoresPeptide Synthesis;Glycan Labeling;Glycan Labeling and Analysis;OthersDerivatization Reagents;Coupling;Derivatization Reagents HPLC;OthersSynthetic Reagents;Peptide Synthesis;UV-VIS;Intermediates of Dyes and Pigments
Mol File:89-25-8.mol
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Structure
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Chemical Properties
Melting point 126-128 °C(lit.)
Boiling point 287 °C265 mm Hg(lit.)
density 1,12 g/cm3
refractive index 1.6300 (estimate)
Fp 191°C/17mm
storage temp. Store at RT
solubility 3.30g/l
form Crystalline Powder
color Yellow to beige
PH4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
Water Solubility 3 g/L (20 ºC)
Merck 14,6713
BRN 609575
CAS DataBase Reference89-25-8(CAS DataBase Reference)
NIST Chemistry Reference3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA Substance Registry System1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 1
RTECS UQ9625000
HS Code 29331990
Hazardous Substances Data89-25-8(Hazardous Substances Data)
ToxicityLD50 orl-rat: 3500 mg/kg LONZA# 08FEB79
MSDS Information
Edaravone English
ACROS English
SigmaAldrich English
ALFA English
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Usage And Synthesis
DescriptionEdaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.
Chemical PropertiesOff white to light yellow powder
OriginatorMitsubishi Pharma (Japan)
Usesantioxidant, lipoxygenase inhibitor
UsesEdaravone inhibits the disease activity in rheumatoid arthritis.
DefinitionChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Brand nameRadicut
HazardToxic by ingestion.
Biological ActivityA radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.
Safety ProfileModerately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.
Purification MethodsCrystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]
Tag:5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one(89-25-8) Related Product Information
1-PHENYLPYRAZOLE Oxazoline 3-Methyl-2-pyrazolin-5-one Pyrazole Paraquat dichloride Methylparaben 2,6-Dimethyl-7-octen-2-ol Methyl 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one PHENYL VALERATE Kresoxim-methyl Methanol Methyl acrylate Basic Violet 1 Cefazolin sodium salt Methyl acetate Acetonitrile Cefazolin