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Sigma-Aldrich
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| Products Intro: |
Product Name:Plasminogen
CAS:9001-91-6
Purity:>= 2.0units/mg protein, lumps and powder, streptokinase dete Package:0.5unit, 5units, 10units, 25units Remarks:P7999
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| | PLASMINOGEN Basic information |
| Product Name: | PLASMINOGEN | | Synonyms: | PLASMINOGEN, GLU-TYPE, HUMAN;PLASMINOGEN, GLU-TYPE, HUMAN PLASMA;PLASMINOGEN, HUMAN;PLASMINOGEN, HUMAN PLASMA;PLASMA TRYPSINOGEN, HUMAN;PROFIBRINOLYSIN;PROFIBRINOLYSIN, HUMAN;GLU-PLASMINOGEN (HUMAN) | | CAS: | 9001-91-6 | | MF: | NULL | | MW: | 0 | | EINECS: | 232-641-9 | | Product Categories: | | | Mol File: | Mol File | ![PLASMINOGEN Structure]() |
| | PLASMINOGEN Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder |
| | PLASMINOGEN Usage And Synthesis |
| Uses | Plasminogen is a single-chain glycoprotein found in human plasma and extracellular fluid. Certain activators, such as tissue plasminogen activator (tPA), convert plasminogen to its active form, plasmin. Plasminogen has been used to study its conversion into plasmin. | | General Description | The plasminogen (PLG) gene is mapped to human chromosome 6q26. Plasminogen protein has a molecular weight of ?90kDa. It is composed of Pan-apple domain at the N-terminal, five kringle domains and serine protease domain at its C-terminal. | | Biochem/physiol Actions | Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β). |
| | PLASMINOGEN Preparation Products And Raw materials |
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