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Prednisone

Prednisone Suppliers list
Company Name: Guangzhou PI PI Biotech Inc
Tel: ; +8618371201331;+8618371201331
Email: sales@pipitech.com;87478684@qq.com
Products Intro: Product Name:Prednisone
CAS:53-03-2
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Prednisone
CAS:53-03-2
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: Product Name:53-03-2
CAS:53-03-2
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Prednisone;Dehydrocortisone fandachem
CAS:53-03-2
Purity:As coa Package:As request Remarks:53-03-2
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
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Products Intro: Product Name:Prednisone
CAS:53-03-2
Purity:99%min Package:1KG;10USD

Prednisone manufacturers

  • Prednisone
  • $0.00 / KG
  • 2022-01-18
  • CAS:53-03-2
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Prednisone
  • $66.00 / KG
  • 2022-01-06
  • CAS:53-03-2
  • Min. Order: 1KG
  • Purity: Above96%
  • Supply Ability: Weekly supply of 100KG
  • Prednisone
  • $10.00 / g/Bag
  • 2021-12-14
  • CAS:53-03-2
  • Min. Order: 10g
  • Purity: 99
  • Supply Ability: 100KG
Prednisone Basic information
Product Name:Prednisone
Synonyms:1,2-Dehydrocortisone;1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione;11,20-trione,17,21-dihydroxy-pregna-4-diene-3;11,20-trione,17,21-hydroxy-pregna-4-diene-3;Ancortone;Bicortone;Colisone;Cortan
CAS:53-03-2
MF:C21H26O5
MW:358.43
EINECS:200-160-3
Product Categories:Antitumors for Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone
Mol File:53-03-2.mol
Prednisone Structure
Prednisone Chemical Properties
Melting point 236-238 °C(lit.)
alpha 169 º (c=0.5, dioxane)
Boiling point 410.86°C (rough estimate)
density 1.1121 (rough estimate)
refractive index 170 ° (C=0.5, Dioxane)
Fp >200℃
storage temp. 2-8°C
solubility Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pKa12.36±0.60(Predicted)
Water Solubility 115mg/L(25 ºC)
Merck 7722
BRN 2065301
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference53-03-2(CAS DataBase Reference)
IARC3 (Vol. 26, Sup 7) 1987
NIST Chemistry ReferencePrednisone(53-03-2)
EPA Substance Registry SystemPrednisone (53-03-2)
Safety Information
Hazard Codes Xn
Safety Statements 36/37/39-45-26-16
Hazardous Substances Data53-03-2(Hazardous Substances Data)
MSDS Information
ProviderLanguage
1,4-Pregnadiene-17a,21-diol-3,11,20-trione English
SigmaAldrich English
Prednisone Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder.
UsesAdrenocortical steroid. Glucocorticoid, antiinflammatory.
UsesDownregulates TNF-α production and NF-κB expression
UsesPrednisone is used for the same indications as cortisone for inflammatory processes, allergies, and adrenal gland insufficiency; however, it is somewhat more active than cortisone and has less of an effect on mineral volume.
IndicationsPrednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.
DefinitionChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.
Brand nameCortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).
General DescriptionOdorless white crystalline powder.
General DescriptionPrednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.
Air & Water ReactionsVery slightly water soluble .
HazardQuestionable carcinogen.
Safety ProfilePoison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
Chemical SynthesisPrednisone is 17α,21-dihydroxypregna-1,4-dien-3,11-20-trione (27.1.31). Prednisone differs from cortisone in the presence of an additional double bond between C1 and C2. There are various ways of synthesizing it. In one of these, as is in the case when synthesizing cortisone, it is synthesized from dihydrocortisone acetate. However, in the given example, this compound undergoes dibromination by molecular bromine, giving 2,4-dibromo-derivative of dihydrocortisone 27.1.30. Dehydrobromination with 3,5-lutidine, followed by subsequent hydrolysis of the acetyl group using potassium bicarbonate gives the desired prednisone (27.1.31). Prednisone is also synthesized by microbiological dehydrogenation of cortisone.

Purification MethodsCrystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]
Prednisone Preparation Products And Raw materials
Raw materialsSelenium dioxide-->Hydrocortisone-->Cortisone acetate
Preparation ProductsDeprodone propionate
Tag:Prednisone(53-03-2) Related Product Information
PREDNISONE SODIUM PHOSPHATE Prednisolone sodium succinate Prednisolone Pro-MACE-C-MOPP protocol MOPP-Bleo protocol Prednisone pivalate Hydrocortisone sodium succinate 1,4-PREGNADIEN-6-ALPHA-METHYL-17,21-DIOL-3,11,20-TRIONE PREDNISONE HEMISUCCINATE:HISTAMINE chloroprednisone 21-acetate PREDNISONE 21-HEMISUCCINATE,PREDNISONE HEMISUCCINATE 1,4-PREGNADIEN-16-BETA-METHYL-17,21-DIOL-3,11,20-TRIONE 21-ACETATE PREDNISONE, [1,2-3H] 1,4-PREGNADIEN-6-ALPHA-METHYL-17,21-DIOL-3,11,20-TRIONE 21-HEMISUCCINATE Pregna-1,4-diene-3,11,20-trione, 17-hydroxy-21-(phosphonooxy)-, disodium salt Prednisone prednisone 21-acetate,PREDNISONE ACETATE Fludrocortisone