- Sevelamer hydrochloride
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- $9.00 / 1KG
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2024-01-08
- CAS:152751-57-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000tons
- Sevelamer hydrochloride
-
- $5.00 / 1kg
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2023-08-16
- CAS:152751-57-0
- Min. Order: 1kg
- Purity: >99%
- Supply Ability: 300000ton
- Sevelamer hydrochloride
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- $1.00 / 1Kg/Bag
-
2023-04-12
- CAS:152751-57-0
- Min. Order: 1Kg/Bag
- Purity: 99.78% HPLC
- Supply Ability: 5000tons/year
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| | Sevelamer hydrochloride Basic information |
| | Sevelamer hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Hot Methanol (Sparingly) | | form | Solid | | color | Pale Yellow |
| | Sevelamer hydrochloride Usage And Synthesis |
| Originator | Renagel,Chugai Pharmaceutical | | Uses | Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease. | | Uses | Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease. | | Definition | ChEBI: Sevelamer hydrochloride is an epoxide. | | Manufacturing Process | Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w,
208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h
and filtered to a 2500 L reactor. The transfer line was rinsed with water (217
kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C
and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for
1.5 h and then heated to reflux for 16 h. The resulting product slurry may be
isolated and washed in decanter centrifuge.
| | Brand name | Renagel (Genzyme). | | Therapeutic Function | Antihyperphosphatemic | | Veterinary Drugs and Treatments | Sevalamer may be useful for treating hyperphosphatemia associated
with chronic renal failure, particularly when oral aluminum
salts are not tolerated. |
| | Sevelamer hydrochloride Preparation Products And Raw materials |
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