2,2-DIMETHYLCYANOACETATE METHYL ESTER synthesis
- Product Name:2,2-DIMETHYLCYANOACETATE METHYL ESTER
- CAS Number:72291-30-6
- Molecular formula:C6H9NO2
- Molecular Weight:127.14
Yield: 73%
Reaction Conditions:
with potassium carbonate in acetone
Steps:
1 Synthesis of N-(N-4-amidinobenzoyl-α,α-dimethyl-β-alanyl)-4-piperidineacetic acid STR7 (1) Methyl 2,2-dimethyl-cyanoacetate
EXAMPLE 1 Synthesis of N-(N-4-amidinobenzoyl-α,α-dimethyl-β-alanyl)-4-piperidineacetic acid STR7 (1) Methyl 2,2-dimethyl-cyanoacetate Methyl cyanoacetate (15 ml) and methyl iodide (200 g) were stirred and refluxed under the presence of potassium carbonate in acetone for 4 days and the potassuim carbonate was then removed by filtration. Acetone was distilled off from the filtrate and the residue was distilled in vacuo (16 mmHg, 76° C.) to yield methyl 2,2-dimethyl-cyanoacetate (19.5 g, 73%). NMR: 1 H (270 MHz, CDCl3) 1.62, s, 6H: 3.83, s, 3H: 13 C(67.5 MHz, CDCl3) 24.6, 38.4, 121.0, 170.0
References:
Nippon Steel Corporation;Nippon Steel Chemical Co., Ltd. US5866592, 1999, A
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