ChemicalBook CAS DataBase List 2,5-DIBROMOANISOLE

2,5-DIBROMOANISOLE synthesis

11synthesis methods

Product Name:2,5-DIBROMOANISOLE
CAS Number:95970-08-4
Molecular formula:C7H6Br2O
Molecular Weight:265.93

19056-40-7 Synthesis

19056-40-7
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$10.00/1g

95970-08-4
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$13.00/1g

Yield: 81%

Reaction Conditions:

Stage #1:4-bromo-3-methoxyaniline with sulfuric acid;sodium nitrite in water at 12;
Stage #2: with hydrogen bromide;copper(I) bromide in water at 40 - 65;

Steps:

2.3 (3) bromine reaction on diazo again
adding 1020 g of 2-bromo-5-aminoanisole to the reaction vessel,Add about 30% sulfuric acid 8380 g and stir.Then, a solution of 455 g of sodium nitrite and 1000 g of water was added dropwise, and the process temperature was controlled at about 12 °C.After the addition is completed, the mixture is stirred for a while to prepare a diazonium salt for use. Add 520 g of cuprous bromide and HBr 1350 g to another reaction flask.The above diazonium salt is added under stirring, and the temperature rises when decomposed, and the controlled temperature is 40 to 65 °C.After the addition, continue to stir, keep the reaction for a period of time, stir, cool, filter,The brown solid 2,5-dibromoanisole was obtained in an amount of 1086 g, and the content was more than 97%, and the yield was 81%.

References:

Changzhou University;Chen Xingquan;Dong Yanmin CN109320403, 2019, A Location in patent:Paragraph 0011; 0013; 0014; 0016; 0018; 0019

67-56-1 Synthesis