ChemicalBook CAS DataBase List 3-METHOXY-4-METHYLBENZALDEHYDE

3-METHOXY-4-METHYLBENZALDEHYDE synthesis

11synthesis methods

Product Name:3-METHOXY-4-METHYLBENZALDEHYDE
CAS Number:24973-22-6
Molecular formula:C9H10O2
Molecular Weight:150.17

4685-50-1

24973-22-6

Dess-Martin periodinane (3 g, 7.07 mmol) was slowly added to a solution of (3-methoxy-4-methylphenyl)methanol (1 g, 6.57 mmol) in dichloromethane (35 mL) at 0 °C. The reaction mixture was stirred continuously at 0°C for 0.5 hours. Subsequently, a portion of the dichloromethane was concentrated under reduced pressure, and the reaction mixture was diluted with ether and washed sequentially with saturated sodium bicarbonate solution, sodium thiosulfate solution and water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 3-methoxy-4-methylbenzaldehyde in quantitative yield.

4685-50-1 Synthesis

4685-50-1
32 suppliers
$110.00/0.5g

24973-22-6
120 suppliers
$6.00/100mg

Yield: 100%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 0; for 0.5 h;

Steps:

2.35
Dess-Martin periodinane (3gm, 7.07 mmol) was added to (3-methoxy-4- methylphenyl)methanol (lgm, 6.57 mmol) in CH₂Cl₂ (35 ml) at O⁰C. After stirring at O⁰C for 0.5h, some of the CH₂Cl₂ was removed, reaction mixture was diluted with ether, washed with sodium bicarbonate solution, sodium thiosulfate solution and water. Organic layer was dried and evaporated to obtain 3-methoxy-4-methylbenzaldehyde in quantitative yield.

References:

ZAPAQ, INC.;THE BOARD OF TRUSTEES OF THE UNVERSITY OF ILLINOIS;OKLAHOMA MEDICAL RESEARCH FOUNDATION WO2006/110668, 2006, A1 Location in patent:Page/Page column 65