ChemicalBook CAS DataBase List 4'-Hydroxyvalerophenone

4'-Hydroxyvalerophenone synthesis

7synthesis methods

Product Name:4'-Hydroxyvalerophenone
CAS Number:2589-71-1
Molecular formula:C11H14O2
Molecular Weight:178.23

4'-Hydroxyvalerophenone is synthesized from phenol and valeryl chloride. It is a raw material intermediate for liquid crystals.

638-29-9
260 suppliers
$14.14/1gm:

108-95-2 Synthesis

108-95-2
708 suppliers
$14.00/25g

2589-71-1
233 suppliers
$7.00/5g

Yield:2589-71-1 98%

Reaction Conditions:

with trifluorormethanesulfonic acid at 0 - 20; for 1 h;regiospecific reaction;Friedel-Crafts acylation;

Steps:

4.3. General procedure of Friedel-Crafts acylation of phenols in TfOH

General procedure: Phenol (0.28 mmol) and acyl chloride (0.28 mmol) were dissolved in TfOH (3 ml) at 0 °C. The reaction mixture was warmed to room temperature for appropriate time in Table 2, then poured into cold water and ethyl acetate. The organic layer was washed with 1 M HCl, saturated NaHCO₃, and saturated NaCl, and dried over MgSO₄, then filtrated. The filtrate was concentrated and the residue was subjected silica column chromatography to afford acylated products. All spectral data were identical with the literatures.²⁷

References:

Murashige, Ryo;Hayashi, Yuka;Ohmori, Syo;Torii, Ayuko;Aizu, Yoko;Muto, Yasuyuki;Murai, Yuta;Oda, Yuji;Hashimoto, Makoto [Tetrahedron,2011,vol. 67,# 3,p. 641 - 649] Location in patent:experimental part

71-23-8 Synthesis