4-Imidazolemethanol hydrochloride synthesis
- Product Name:4-Imidazolemethanol hydrochloride
- CAS Number:32673-41-9
- Molecular formula:C4H7ClN2O
- Molecular Weight:134.56
Yield:32673-41-9 87.5%
Reaction Conditions:
with hydrogenchloride;ammonium cerium (IV) nitrate;sodium ethanolate in ethanol;acetonitrile; pH=10 at 60; for 8 h;Reagent/catalyst;
Steps:
3 Example 3
A mixture of acetonitrile and ethanol in a volume ratio of 2: 1 was added to the reactor,100 mmol of 1,3-dihydroxyacetone and 200 mmol of formaldehyde were dissolved in an organic solvent,100 mmol of cerium ammonium nitrate was added,Under normal pressure 60 conditions,Adding sodium ethoxide to adjust the pH to 10,15 mmol of catalyst was added,Stirring reaction 8h, obtained 4-hydroxymethyl imidazole,After completion of the reaction,Dropping concentrated HCl,Adjust pH = 2,filter,The filtered solid,Washed with saturated brine,Recrystallization from ethanol,Dried in vacuo to give the product 4-hydroxymethylimidazole hydrochloride.The purity of the prepared 4-hydroxymethylimidazolidine hydrochloride was 98.2%The yield was 87.5%.
References:
Ye, Fang CN106349165, 2017, A Location in patent:Paragraph 0016-0030
96-26-4
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