DIMETHYLPHOSPHINE OXIDE synthesis
- Product Name:DIMETHYLPHOSPHINE OXIDE
- CAS Number:7211-39-4
- Molecular formula:C2H7OP
- Molecular Weight:78.05
75-16-1
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762-04-9
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$10.00/10g
7211-39-4
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$6.00/250mg
Yield:7211-39-4 88.79%
Reaction Conditions:
in tetrahydrofuran at 0 - 20; for 16 h;Inert atmosphere;
Steps:
1.1J Example 1J Dimethylphosphineoxide
MeMgBr (1.30 mol, 434.46mL) in THF (800mL) was cooled to 0 deg.C. Under the protection of N2, diethyl phosphonate (60.0 g, 434.46 mmol, dissolved in 40mL THF) was added dropwise to the reaction mixture. 2h dropwise additon maintaining the internal temperature not higher than 0 deg.C . After the addition, the reaction mixture was warmed to 20 deg.C and stirred for 14 hours. Solution of potassium carbonate (177 g, was dissolved in 250mL of water) was added to the reaction mixture to quench the reaction. White solid appeared, the mixture was filtered, the filter cake washed with ethanol (100 mL) and washed, the filtrate was concentrated, filtered and concentrated to occur during the solid. Toluene (200 mL) was added to the filtrate, and concentrated to dryness to remove excess water, to give the title compound (30.11 g, 385.78 mmol, 88.79% yield) as a colorless viscous oil.
References:
CN105330698,2016,A Location in patent:Paragraph 0188; 0189; 0190; 0191
676-58-4
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$15.00/25ml
762-04-9
343 suppliers
$10.00/10g
7211-39-4
152 suppliers
$6.00/250mg
676-58-4
297 suppliers
$15.00/25ml
7211-39-4
152 suppliers
$6.00/250mg
917-64-6
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$45.00/10ml
762-04-9
343 suppliers
$10.00/10g
7211-39-4
152 suppliers
$6.00/250mg
121-45-9
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$14.00/5g
512-56-1
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$16.00/25g
7211-39-4
152 suppliers
$6.00/250mg