N-Succinimidyl 6-maleimidohexanoate synthesis
- Product Name:N-Succinimidyl 6-maleimidohexanoate
- CAS Number:55750-63-5
- Molecular formula:C14H16N2O6
- Molecular Weight:308.29
6066-82-6
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$5.00/10g
55750-53-3
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$9.00/1g
55750-63-5
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$6.00/50mg
Yield:55750-63-5 95%
Reaction Conditions:
with dicyclohexyl-carbodiimide in acetonitrile at 0 - 20;Inert atmosphere;
Steps:
2 Example 2Synthesis of Mc-OSu
Under nitrogen protection, 4.7 g (22 mmol) of MC and 25 g (22 mmol) of HOSu were added to 50 ml of acetonitrile.Another 4.5 g (22 mmol) of DCC was dissolved in 25 ml of acetonitrile,Keeping the internal temperature around 0°C,It was slowly dropped into the reaction solution.The reaction solution was reacted at 0°C for 2 hours and then reacted overnight at room temperature.filter,The filter cake was washed with acetonitrile 10ml×3.The filtrate was concentrated to dryness under reduced pressure.The resulting oil was dried under reduced pressure at room temperature for 6 h to give 6.4 g of light brown solid.Yield 95%.
References:
Sichuan Bai Li Pharmaceutical Co., Ltd.;Zhu Yi;Wang Yiqian;Zhuo Shi;Li Jie;Chen Lan;Wan Weili;Yu Yongguo CN107789630, 2018, A Location in patent:Paragraph 0064; 0065; 0066
108-31-6
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6066-82-6
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60-32-2
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55750-63-5
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74124-79-1
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55750-53-3
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$9.00/1g
55750-63-5
293 suppliers
$6.00/50mg
60-32-2
588 suppliers
$5.00/10g
55750-63-5
293 suppliers
$6.00/50mg
6066-82-6
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$5.00/10g
57079-14-8
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55750-63-5
293 suppliers
$6.00/50mg