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ChemicalBook CAS DataBase List Phentolamine

Phentolamine synthesis

5synthesis methods
Phentolamine, 2-[[N-(3′-hydroxyphenyl)-para-toluidion]methyl]-2- imidazoline (12.2.8), is synthesized by alkylation of 3-(4-methylanilino)phenol using 2-chloromethylimidazoline [36, 37].

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: styrene; 10 wt% Pd(OH)2 on carbon / toluene / 24 h / 140 °C / 3750.38 Torr / Flow reactor
2: toluene / Reflux

References:

Ichitsuka, Tomohiro;Kobayashi, Shū;Koumura, Nagatoshi;Sato, Kazuhiko;Takahashi, Ikko [Angewandte Chemie - International Edition,2020,vol. 59,# 37,p. 15891 - 15896][Angew. Chem.,2020,vol. 132,# 37,p. 16025 - 16030,6]

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