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Salicylazosulfapyridine

Salicylazosulfapyridine
Salicylazosulfapyridine
CAS No.
599-79-1
Chemical Name:
Salicylazosulfapyridine
Synonyms
SSZ;sasp;si-88;accucol;rorasul;sas-500;azopyrin;reupirin;salisulf;sulcolon
CBNumber:
CB0181156
Molecular Formula:
C18H14N4O5S
Formula Weight:
398.4
MOL File:
599-79-1.mol

Salicylazosulfapyridine Properties

Melting point:
260-265 °C (dec.)(lit.)
storage temp. 
Refrigerator
solubility 
NH4OH 1 M: 50 mg/mL, clear, red
Water Solubility 
<0.1 g/100 mL at 25 ºC
Merck 
8942
CAS DataBase Reference
599-79-1(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 2-hydroxy-5-[[4-[(2-pyridinylamino) sulfonyl]phenyl]azo]-(599-79-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  22-29/56-45
RIDADR  3077
WGK Germany  2
RTECS  VO6250000
8
HS Code  29350090
Hazardous Substances Data 599-79-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Salicylazosulfapyridine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1636005 Sulfasalazine United States Pharmacopeia (USP) Reference Standard 599-79-1 125mg $279.9 2017-11-08 Buy
Sigma-Aldrich S0883 Sulfasalazine analytical standard, ≥98% (HPLC) 599-79-1 10g $48.5 2017-11-08 Buy
Cayman Chemical 15025 Sulfasalazine ≥98% 599-79-1 5g $25 2017-11-08 Buy
Cayman Chemical 15025 Sulfasalazine ≥98% 599-79-1 10g $38 2017-11-08 Buy
Sigma-Aldrich S0883 Sulfasalazine analytical standard, ≥98% (HPLC) 599-79-1 50g $153 2017-11-08 Buy

Salicylazosulfapyridine Chemical Properties,Uses,Production

Chemical Properties

Brownish-Yellow Crystals

Uses

Anti-inflammatory (gastrointestinal). Has been used in granulomatous colitis.

Uses

anticolitis and Crohn's disease

Uses

Sulfasalazine is an anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.

Uses

An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer

Definition

ChEBI: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Uses

Sulfasalazine is a prodrug of the anti-inflammatory agent 5-aminosalicylic acid that is covalently linked to the antibiotic sulfapyridine by an azo bond. This bond is rapidly cleaved by bacteria in the terminal ileum and colon, thus releasing the active anti-inflammatory component. It has long been used in treatment of inflammatory bowel disease and rheumatoid arthritis because of its ability to induce T lymphocyte apoptosis, modulate inflammatory mediators from both cyclooxygenase/5-lipoxygenase pathways and NF-κB signaling pathways, attenuate transcription of proinflammatory cytokines, and activate PPARγ.[Cayman Chemical]

General Description

Odorless yellow or brownish-yellow to orange powder. Tasteless.

Air & Water Reactions

Light sensitive and may be sensitive to prolonged exposure to air. Dust can be explosive when suspended in air at specific concentrations. Insoluble in water.

Fire Hazard

Flash point data for Salicylazosulfapyridine are not available; however, Salicylazosulfapyridine is probably combustible.

Salicylazosulfapyridine Preparation Products And Raw materials

Raw materials

Preparation Products


Salicylazosulfapyridine Suppliers

Global( 182)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2221 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3589 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519 sales@RHFChem.com China 2364 56
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 sales@tcishanghai.com.cn China 22833 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44197 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 20036 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32539 50

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