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Salicylazosulfapyridine

CAS No.599-79-1
Chemical Name:Salicylazosulfapyridine
Synonyms:SSZ;sasp;si-88;accucol;rorasul;sas-500;azopyrin;reupirin;salisulf;sulcolon
CBNumber:CB0181156
Molecular Formula:C18H14N4O5S
Formula Weight:398.4
MOL File:599-79-1.mol
Salicylazosulfapyridine Property
Melting point : 260-265 °C (dec.)(lit.)
storage temp. : Refrigerator
solubility : NH4OH 1 M: 50 mg/mL, clear, red
Water Solubility : <0.1 g/100 mL at 25 ºC
Merck : 8942
CAS DataBase Reference: 599-79-1(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 2-hydroxy-5-[[4-[(2-pyridinylamino) sulfonyl]phenyl]azo]-(599-79-1)
Safety
Hazard Codes : Xn
Risk Statements : 42/43
Safety Statements : 22-29/56-45
WGK Germany : 2
RTECS : VO6250000
F : 8
Hazardous Substances Data: 599-79-1(Hazardous Substances Data)

Salicylazosulfapyridine Chemical Properties,Usage,Production

Chemical Properties
Brownish-Yellow Crystals
Uses
Anti-inflammatory (gastrointestinal). Has been used in granulomatous colitis.
Uses
anticolitis and Crohn's disease
Uses
Sulfasalazine is an anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.
Definition
ChEBI: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Uses
Sulfasalazine is a prodrug of the anti-inflammatory agent 5-aminosalicylic acid that is covalently linked to the antibiotic sulfapyridine by an azo bond. This bond is rapidly cleaved by bacteria in the terminal ileum and colon, thus releasing the active anti-inflammatory component. It has long been used in treatment of inflammatory bowel disease and rheumatoid arthritis because of its ability to induce T lymphocyte apoptosis, modulate inflammatory mediators from both cyclooxygenase/5-lipoxygenase pathways and NF-κB signaling pathways, attenuate transcription of proinflammatory cytokines, and activate PPARγ.[Cayman Chemical]
General Description
Odorless yellow or brownish-yellow to orange powder. Tasteless.
Air & Water Reactions
Light sensitive and may be sensitive to prolonged exposure to air. Dust can be explosive when suspended in air at specific concentrations. Insoluble in water.
Fire Hazard
Flash point data for Salicylazosulfapyridine are not available; however, Salicylazosulfapyridine is probably combustible.
Salicylazosulfapyridine Preparation Products And Raw materials
Raw materials
Benzenesulfonyl chloride Acetic acid glacial 2-Aminopyridine Sulfapyridine Acetanilide
Preparation Products
Salicylazosulfapyridine Suppliers      Global( 171)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
Shanghai QianJin Chemical Technology Co., Ltd 021-20900665,17321230821021-20900665shqjchemical@163.comChina 1069 55
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)+86-21-57758967sales@boylechem.comChina 2221 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.comChina 96832 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)sh@meryer.comChina 40403 62
INTATRADE GmbH +49 3493/605464+49 3493/605470sales@intatrade.deGermany 3589 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-503281093bsc@sina.comChina 15950 69
TAIYUAN RHF CO.,LTD. +86 351 7031519+86 351 7031519sales@RHFChem.comChina 2364 56
TCI (Shanghai) Development Co., Ltd. 800-988-0390021-67121385sales@tcishanghai.com.cnChina 22833 81
Energy Chemical 021-58432009 / 400-005-6266021-58436166-800info@energy-chemical.comChina 44198 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070; 010-68547217+86-25-83453306sales@chemlin.com.cnChina 20079 64
 
599-79-1(Salicylazosulfapyridine)Related Search:
Sulfanilamide Sulfapyridine salazosulfamide 2-HYDROXY-5-PHENYLAZOBENZALDEHYDE Salicylazosulfapyridine AQUANTRAAL PHENYL VALERATE Sulfuryl chloride Salicylic acid Chromium picolinate Methyl salicylate CHLOROPHOSPHONAZO III BENZOICACID Acetylsalicylic acid Phenylacetic acid
salicylazosulfapyridine SALAZOSULFAPYRIDINE SULFASALAZINE SSZ LABOTEST-BB LT00772281 5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid 5-[4-(2-PYRIDYLSULFAMOYL)PHENYLAZO]SALICYLIC ACID 599-79-1 Antibiotics Antibiotics A to Z Antibiotics N-S BioChemical 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid 2-hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)-benzoicaci 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]-benzoicaci 4-(pyridyl-2-amidosulfonyl)-3’-carboxy-4’-hydroxyazobenzene 5-((p-(2-pyridylsulfamoyl)phenyl)azo)-salicylicaci 5-(4-(2-pyridylsulfamoyl)phenylazo)-2-hydroxybenzoicacid 5-(p-(2-pyridylsulfamyl)phenylazo)salicylicacid accucol asulfidine azopyrin azopyrine azosulfidin azulfidine benzosulfa colo-pleon reupirin rorasul s.a.s.-500 salazopyridin salazopyrin salazosulfapyridin salisulf sas-500 sasp si-88 sulcolon sulfasalazin sulphasalazine w-tsasporal CARBOXYLIC ACID C18H14N4O5S Benzoic acid, 2-hydroxy-5-4-(2-pyridinylamino)sulfonylphenylazo- SULFASALAZINE USP 26,EP 4 SULFASALAZINE(SASP)(NDC:55631-0130) SALICYLAZOSULPHAPYRIDINE SALICYLICACID,5-((PARA-(2-PYRIDYLSULFAMOYL)PHENYL)AZO)- sulfasalazine,SASP 599-79-2 APIs Antibiotics for Research and Experimental Use Biochemistry Sulfonamides (Antibiotics for Research and Experimental Use) Intermediates & Fine Chemicals Pharmaceuticals 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl-benzoic acid Cytokine signaling
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