| Identification | More | [Name]
4-Amino-1-butanol | [CAS]
13325-10-5 | [Synonyms]
4-AMINO-1-BUTANOL
4-AMINOBUTANOL
4-AMINOBUTYL ALCOHOL
4-AMINO-N-BUTYL ALCOHOL
4-HYDROXYBUTYLAMINE
4-HYDROXY-N-BUTYLAMINE
BUTANOLAMINE
DELTA-AMINO-N-BUTYL ALCOHOL
H-ABUT(4)-OL
N-ABU(4)-OL
NH2-(CH2)4-OH
1-Butanol, 4-amino-
4-aminobutan-1-ol
4-Aminobutanol-1
4-hdyroxybutylamine
4-hydroxybutanamine
H2NCH2(CH2)2CH2OH
4-Amino-1-Butanol98%
4-Aminobutane-1-ol | [EINECS(EC#)]
236-364-4 | [Molecular Formula]
C4H11NO | [MDL Number]
MFCD00008230 | [Molecular Weight]
89.14 | [MOL File]
13325-10-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Very light clear yellow liquid | [Melting point ]
16-18 °C (lit.) | [Boiling point ]
206 °C (lit.) | [density ]
0.967 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D ~1.462(lit.)
| [Fp ]
226 °F
| [storage temp. ]
Store at R.T. | [solubility ]
Acetonitrile (Slightly), Chloroform (Sparingly), Methanol (Slightly) | [form ]
Liquid | [pka]
15.10±0.10(Predicted) | [color ]
Clear colorless to slightly yellow | [Water Solubility ]
MISCIBLE | [Sensitive ]
Air Sensitive & Hygroscopic | [BRN ]
1731411 | [Stability:]
Unstable in Aqueous Solution | [CAS DataBase Reference]
13325-10-5(CAS DataBase Reference) | [NIST Chemistry Reference]
NH2(CH2)4OH(13325-10-5) | [EPA Substance Registry System]
1-Butanol, 4-amino- (13325-10-5) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S25:Avoid contact with eyes . | [RIDADR ]
UN 2735 8/PG 3
| [WGK Germany ]
3
| [F ]
34 | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29221980 |
| Hazard Information | Back Directory | [Description]
4-Amino-1-butanol (4AB,13325-10-5) is an important pharmaceutical intermediate compound and a precursor of biodegradable polymers for gene delivery. It can be used in organic synthesis and biological properties studies, among others. In addition, 4-Amino-1-butanol (4AB) has been shown to have a higher CO2 solubility than 2-amino-1-ethanol (MEA), which is potentially useful in solving problems related to flue gas purification[1-2].
| [Chemical Properties]
Very light clear yellow liquid | [Uses]
4-Amino-1-butanol(13325-10-5) is a useful intermediate in a variety of organic synthesis. It is mainly used in personal-care products, preparation of water soluble cationic flocculants and ion exchange resins as well as in the preparation of beta-lactam antibiotics. It is used for the production of efficient anionic emulsifiers, nonionic polyethylene emulsions, water treatment, metal treatment and absorption of carbon dioxide gas. It is used as a pigment dispersion aid and curing agent in selected textile -resins.
| [Preparation]
4-Amino-1-butanol (4AB,13325-10-5) can be prepared by microbiological methods. we report for the first time the fermentative production of 4AB from glucose by metabolically engineered Corynebacterium glutamicum harboring a newly designed pathway comprising a putrescine (PUT) aminotransferase (encoded by ygjG) and an aldehyde dehydrogenase (encoded by yqhD) from Escherichia coli, which convert PUT to 4AB. Application of several metabolic engineering strategies such as fine-tuning the expression levels of ygjG and yqhD, eliminating competing pathways, and optimizing culture condition further improved 4AB production. Fed-batch culture of the final metabolically engineered C. glutamicum strain produced 24.7?g/L of 4AB[1].
| [References]
[1] CINDY PRICILIA SURYA PRABOWO. Microbial production of 4-amino-1-butanol, a four-carbon amino alcohol[J]. Biotechnology and Bioengineering, 2020. DOI:10.1002/bit.27438.
[2] ZULKIFLI IDRIS . Equilibrium solubility of carbon dioxide in aqueous solutions of 3-amino-1-propanol, 4-amino-1-butanol and 5-amino-1-pentanol at low partial pressures[J]. Fluid Phase Equilibria, 2015. DOI:10.1016/j.fluid.2014.11.028.
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