| Identification | More | [Name]
1-Boc-3-(Amino)azetidine | [CAS]
193269-78-2 | [Synonyms]
1-BOC-3-(AMINO)AZETIDINE
1-BOC-3-AMINOAZETIDINE HYDROCHLORIDE
3-AMINO-1-BOC-AZETIDINE
3-AMINO-1-N-BOC-AZETIDINE
3-AMINO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
3-AMINO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE
3-AMINOAZETIDINE, N1-BOC PROTECTED
TERT-BUTYL 3-AMINOAZETIDINE-1-CARBOXYLATE
1-N-Boc-3-aminoazetidine
3-amino-1-azetidinecarboxylate
3-Aminoazetidine, N1-BOC protected 97%
1-Boc-3-Aminoazatidine
3-AMINO-1-BOC-AZETIDINE 98%
N-BOC-3-AMINOAZETIDINE HYDROCHLORIDE
Boc-3-(Amino)azetidine | [EINECS(EC#)]
205-071-3 | [Molecular Formula]
C8H16N2O2 | [MDL Number]
MFCD01861753 | [Molecular Weight]
172.22 | [MOL File]
193269-78-2.mol |
| Chemical Properties | Back Directory | [Boiling point ]
79-81 3mm | [density ]
1.1g/ml | [refractive index ]
1.4650 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO, Methanol, Water | [form ]
Oil | [pka]
8.29±0.20(Predicted) | [color ]
Clear Colourless to Pale Yellow | [InChI]
InChI=1S/C8H16N2O2/c1-8(2,3)12-7(11)10-4-6(9)5-10/h6H,4-5,9H2,1-3H3 | [InChIKey]
WPGLRFGDZJSQGI-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CC(N)C1 | [CAS DataBase Reference]
193269-78-2(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
1-Boc-3-(Amino)azetidine are widely used and valued as pharmaceutical intermediates. In recent years, numerous new compounds have been successfully prepared and tested through various functional group modifications, many of which exhibit good pharmaceutical activity. For example, 1-diphenylmethyl-3-aminoazacyclic butane and 1-diphenylmethyl-3-hydroxy-3-aminomethylazacyclic butane have been used in the synthesis of some antibacterial and antidepressant drugs. 1-tert-butoxycarbonyl-3-aminocyclobutane is also an important pharmaceutical intermediate used in the synthesis of IRAK-4 inhibitors. |
| Hazard Information | Back Directory | [Chemical Properties]
Clear Colourless to Pale Yellow Oil | [Synthesis]
General procedure for the synthesis of tert-butyl 3-aminoazetidine-1-carboxylate from 1-BOC-3-azidoazetidine: tert-butyl 3-azidoazetidine-1-carboxylate (0.420 g, 2.19 mmol) was dissolved in EtOAc (20 mL) and 10% Pd/C (100 mg) was added. The reaction mixture was stirred under hydrogen atmosphere (balloon). After 12 h of reaction, the catalyst was removed by filtration through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give a colorless oily product (1.76 g, 99% yield), which could be used in subsequent reactions without further purification.1H NMR (CDCl3): δ 1.50 (s, 9H). | [References]
[1] Patent: WO2004/74283, 2004, A1. Location in patent: Page 40
[2] Patent: US2011/166121, 2011, A1. Location in patent: Page/Page column 56
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22 |
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