| Identification | More | [Name]
Zinc acetate | [CAS]
557-34-6 | [Synonyms]
ZINC ACETATE
Acetic acid, zinc(II) salt
aceticacid,zinc(ii)salt
ai3-04465
Dicarbomethoxyzinc
siltexcl4
Zinc diacetate
zinc(ii)acetate
Zincacetate,anhydrous
zincdiacetate
ZINC ACETATE, 99.99% METALS BASIS
ZINC ACETATE SOLUTION 1M
ZINC ACETATE ANHYDROUS EXTRA PURE 99-102% PHARMACEUTICAL GRADE
ZINC ACETATE ANHYDROUS 99.98% (METALS BASIS)
ZINC ACETATE ANHYDROUS 99+%
ZINC ACETATE ANHYDROUS 99.7%
ZincAcetateUsp
ZincAcetateBp
Zinc acetate, pure, 99%
zinc acetate solution | [EINECS(EC#)]
209-170-2 | [Molecular Formula]
C4H6O4Zn | [MDL Number]
MFCD00012454 | [Molecular Weight]
183.48 | [MOL File]
557-34-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
83-86 °C
| [Boiling point ]
908°C | [density ]
1.84 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.001Pa at 25℃ | [Fp ]
12 °C | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Powder | [pka]
4.756[at 20 ℃] | [color ]
Yellow to brown to gray-green | [Specific Gravity]
1.84 | [Water Solubility ]
Soluble in water, alcohol, dilute mineral acids and alkalies. | [Sensitive ]
Hygroscopic | [Merck ]
14,10128 | [InChIKey]
DJWUNCQRNNEAKC-UHFFFAOYSA-L | [Uses]
Medicine (astringent), preserving wood, textile
dyeing (mordant and resist), zinc chromate,
laboratory reagent, cross-linking agent for polymers,
ingredient of dietary supplements (up to 1 mg
daily), feed additive, ceramic glazes. | [CAS DataBase Reference]
557-34-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Zinc acetate(557-34-6) | [EPA Substance Registry System]
557-34-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N,Xi,F | [Risk Statements ]
R36:Irritating to the eyes.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R22:Harmful if swallowed.
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S39:Wear eye/face protection .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
3
| [RTECS ]
AK1500000
| [TSCA ]
Yes | [HazardClass ]
9 | [HS Code ]
29152990 | [Hazardous Substances Data]
557-34-6(Hazardous Substances Data) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Zinc oxide-->Zinc acetate dihydrate | [Preparation Products]
cadmium dioleate-->ZINC 1,4,8,11,15,18,22,25-OCTABUTOXY- PHTHALOCYANINE-->1,4-Diacetoxybenzene-->ZINC 2,11,20,29-TETRA-TERT-BUTYL-2,3-NAPHTHALOCYANINE |
| Hazard Information | Back Directory | [Description]
Zinc acetate (chemical formula: Zn(O2CCH3)2) is a kind of salt commonly existing in the dihydrate form. It appears as colorless solid. It is produced through the reaction between zinc oxide with acetate acid. Given that zinc is an essential element for growth and development of human body, zinc acetate can be used as a dietary supplement for the treatment of zinc deficiency. It plays an important role for the synthesis of cholesterol, protein, and fats. It can also be used as an astringent, styptic and emetic. In industry, it has various kinds of applications including wood preservation, manufacturing of other zinc salts as well as ethylene acetate, being used as a dye mordant, and analytical reagent. | [Chemical Properties]
White crystalline powder | [Chemical Properties]
Zinc acetate occurs as white crystalline, lustrous plates with a faint
acetic odor and an astringent taste. | [Physical properties]
The acetate group is capable of binding to metal ions in a variety of ways through its two oxygen atoms and several connectivities are observed for the various hydrates of zinc acetate. Anhydrous zinc acetate adopts a polymeric structure consisting of zinc coordinated to four oxygen atoms in a tetrahedral environment, each tetrahedron being connected to neighbors by the acetate groups . The acetate ligands are not bidentate. In contrast, most metal diacetates feature metals in octahedral coordination with bidentate acetate groups. In zinc acetate dihydrate the zinc is octahedral, wherein both acetate groups are bidentate.
2 - 5 - Heating pad
Heating Zn(CH3CO2)2 in a vacuum results in loss of acetic anhydride, leaving a residue of ""basic zinc acetate,"" with the formula Zn4O(CH3CO2)6. This cluster compound has the tetrahedral structure shown below. This species closely resembles the corresponding beryllium compound, although it is slightly expanded with Zn-O distances ～1.97 vs ～1.63 Å for Be4O(OAc)6. | [Application]
3–1-Dietary and medicinal applications
Zinc acetate is used as a dietary supplement and in lozenges used to treat the common cold. Zinc acetate alone is thought to be a more effective treatment than zinc gluconate. Zinc acetate can also be used to treat zinc deficiencies. As an oral daily supplement it is used to inhibit the body's absorption of copper as part of the treatment for Wilson's disease. Zinc acetate is also sold as an astringent in the form of an ointment, a topical lotion; or combined with an antibiotic such as erythromycin for the topical treatment of acne. Furthermore Zinc acetate is commonly sold as a topical anti-itch ointment.
3–2-Industrial applications
Industrial applications include wood preserving, manufacturing other zinc salts, polymers, manufacture of ethylene acetate, as a dye mordant, and analytical reagent. Zinc acetate is a precursor via a sol-gel route to the transparent semi conductor zinc oxide. | [Definition]
ChEBI: An acetate salt in which the cationic component is zinc(2+). | [Preparation]
Zinc acetate is prepared by the reaction of acetic acid with zinc oxide followed by crystallization (crystals of dihydrate obtained): ZnO + 2CH3COOH → (CH3COO)2Zn + H2O. | [Production Methods]
Zinc acetate is synthesized by reacting zinc oxide with glacial acetic
acid, with subsequent crystallization, separation by centrifugation,
and drying and milling of the crystals. No organic solvents are used
during the synthesis. | [Flammability and Explosibility]
Nonflammable | [Pharmaceutical Applications]
Zinc acetate has been used as an excipient in a variety of
pharmaceutical formulations including topical gels, lotions, and
solutions, and subcutaneous injections. It has also been investigated
for use in an oral controlled-release formulation for water-soluble
drugs in combination with sodium alginate and xanthan gum.
Therapeutically, zinc acetate has been used in oral capsules for
the treatment of Wilson’s disease. Zinc acetate has also been
demonstrated to be effective as a spermicide in vaginal contraceptives. | [Safety]
Zinc acetate is used in topical pharmaceutical formulations and
subcutaneous injections, where it is generally regarded as relatively
nontoxic and nonirritant when used as an excipient. However, zinc
acetate is poisonous by intravenous and intraperitoneal routes; it is
also moderately toxic following oral consumption.
Zinc acetate:
LD50 (rat, oral): 2.510 g/kg
LD50 (mouse, IP): 0.057 g/kg | [Veterinary Drugs and Treatments]
Zinc sulfate is used systemically as a nutritional supplement in a
variety of species. Oral zinc acetate has been shown to reduce copper
toxicity in susceptible dog breeds (Bedlington Terriers, West
Highland White Terriers) with hepatic copper toxicosis. Zinc therapy
may also be of benefit in the treatment of hepatic fibrosis in
the dog. Zinc sulfate is used topically as an astringent and as a weak
antiseptic both for dermatologic and ophthalmic conditions. | [storage]
Zinc acetate loses water of hydration above 101℃. Zinc acetate
should be stored in an airtight container in a cool, dry, place. | [Incompatibilities]
Zinc acetate is incompatible with oxidizing agents, zinc salts, alkalis
and their carbonates, oxalates, phosphates, and sulfides. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (SC injections;
topical lotions and solutions). Included in medicines licensed in the
UK. | [References]
https://en.wikipedia.org/wiki/Zinc_acetate
https://pubchem.ncbi.nlm.nih.gov/compound/Zinc_acetate_dihydrate#section=GHS-Classification |
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