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Warfarin Produkt Beschreibung

CAS-Nr.81-81-2
Bezeichnung:Warfarin
Englisch Name:Warfarin
Synonyma:
RAX;Ratox;Rosex;D-Con;Co-rax;Ratron;temusw;warf42;Kumadu;Warfin
CBNumber:CB0413732
Summenformel:C19H16O4
Molgewicht:308.33
MOL-Datei:81-81-2.mol
Warfarin physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 162-164 °C(lit.)
Siedepunkt:: 356°C
Dichte: 1.1411 (rough estimate)
Brechungsindex: 1.4434 (estimate)
Flammpunkt:: 2℃
storage temp. : 2-8°C
pka: pKa 4.90±0.01(H2O t = 25±0.5 I = 0.15 (KCl))(Approximate)
Aggregatzustand: Crystalline
Farbe: Colorless
Wasserlöslichkeit: Practically insoluble
Merck : 13,10097
BRN : 8868198
Expositionsgrenzwerte: NIOSH REL: TWA 0.1 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.1 mg/m3; ACGIH TLV: TWA 0.1 mg/m3.
CAS Datenbank: 81-81-2(CAS DataBase Reference)
NIST chemische Informationen: 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin(81-81-2)
EPA chemische Informationen: 2H-1-Benzopyran- 2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- (81-81-2)
Sicherheit
Kennzeichnung gefährlicher: T,T+,Xn,F
R-Sätze:: 61-48/25-52/53-28-21-36-20/21/22-11
S-Sätze:: 53-45-61-52-36/37-28-26-16
RIDADR : UN 2811 6.1/PG 1
WGK Germany : 3
RTECS-Nr.: GN4550000
HazardClass : 6.1(a)
PackingGroup : I
HS Code : 29322090
Giftige Stoffe Daten: 81-81-2(Hazardous Substances Data)
Toxizität: EC50 (24-hour) for Daphnia magna 88.8 mg/L (Lilius et al., 1995); acute oral LD50 for rats 186 mg/kg (Hartley and Kidd, 1987), 3 mg/kg (RTECS, 1985)

Warfarin Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
GERUCHLOSES, GESCHMACKLOSES, FARBLOSES BIS WEISSES, KRISTALLINES PULVER.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.
CHEMISCHE GEFAHREN
Reagiert sehr heftig mit starken Oxidationsmittelnunter Feuer- und Explosionsgefahr.
ARBEITSPLATZGRENZWERTE
TLV: 0,1 mg/m?(als TWA); (ACGIH 2005).
MAK: 0,5 mg/m?(Einatembare Fraktion); Spitzenbegrenzung: überschreitungsfaktor II(2); (DFG 2008).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Möglich sind Auswirkungen auf das Blut mit nachfolgender Blutung. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Fruchtbarkeitsschädigend oder entwicklungsschädigend.
LECKAGE
Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R61:Kann das Kind im Mutterleib schädigen.
R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S52:Nicht großflächig für Wohn- und Aufenthaltsräume zu verwenden.
Chemische Eigenschaften
Colorless crystals; odorless; tasteless. Soluble in acetone, dioxane; slightly soluble in methanol, ethanol; very soluble in alkaline aqueous solution; insoluble in water and benzene.
Chemische Eigenschaften
Warfarin is a colorless, odorless crystalline solid.
Verwenden
Pesticide and rodenticide
Verwenden
Coumadin is widely used as an anticoagulant for various systemic diseases such as venous thromboembolism, cardiac arrhythmia, following myocardial infarction, and hematologic abnormalities, among others. However, the efficacy of coumadin for CRVO is not established. It was reported that 13 of 354 patients taking warfarin developed CRVO despite maintaining therapeutic levels of the anticoagulant.
Verwenden
Anticoagulant.
Application
Warfarin is an anti-coagulant used to prevent heart attacks, strokes, and the formation of blood clots. It interferes with the use of vitamin K in the required carboxylation of several vitamin K-dependent proteins in the clotting cascade, preventing the initiating of clotting. (±)-Warfarin is a racemic mixture of 2 optically active isomers. (±)-Warfarin has a half-life of 36-42 hours in circulation, bound to plasma proteins, and accumulates in the liver, where the two isomers are metabolized by different pathways. 
Trademarks
Athrombin- K (Purdue Frederick);Coumadine;Marevan;Mervan;Sofarin;Waran;Warfilone.
Weltgesundheitsorganisation (WHO)
Warfarin, a coumarin anticoagulant, was introduced into medicine in 1950 for the prevention and managementof thrombo-embolic disorders. Its use during the first trimester of pregnancy has been associated with birth malformations, particularly in relation to cranial and limb development, and there have been reports of foetal death due to haemorrhage following administration of the drug during the late stages of pregnancy. The decision of the Egyptian agency to requrie a warning regarding teratogenicity to be included in the approved information of products containing warfarin beings the text of the package insert in line with those approved in other countries. Warfarin is included in the WHO Model List of Essential Drugs.
Reaktivität anzeigen
Warfarin is incompatible with the following: Strong oxidizers .
Health Hazard
Warfarin is classified as very toxic. Probable oral lethal dose in humans is 50-500 mg/kg, between 1 teaspoon and 1 ounce for a 150 lb. person. Material is an anticoagulant. Toxic effects other than hemorrhage are rarely seen in humans. Material is believed to be teratogenic in humans. Persons with a history of blood disorders with bleeding tendencies would be expected to be at increased risk from exposure.
Health Hazard
Highly toxic substance; exhibits acute,delayed and chronic effects. Ingestion of adose of 3–15 g is thought to be fatal toadult human. It is an anticoagulant causinghemorrhage. The toxic symptoms whichbegin a few days or weeks after ingestioninclude bleeding of nose and gums, pallorand blood in the urine and feces. Anothersymptom may be hematomas around jointsand hip. If the dose is large or lethalthe delayed effects may lead to cerebralhemorrhage, paralysis and death. It exhibitedteratogenic effects in laboratory animals.The LD50 values reported in the literaturewidely vary.
Brandgefahr
Contact with strong oxidizers may cause fires and explosions. Toxic gases and vapors (e.g., carbon monoxide) may be released in heating to decomposition. Avoid strong oxidizers.
Landwirtschaftliche Anwendung
Rodenticide: Warfarin and its sodium salt is an anticoagulant rodenticide used for controlling rats and house mice in and around homes, animal and agricultural premises, and commercialand industrial sites. It is effective in very low dosages. About a week is required before a marked reduction in the rodent population is noticeable. Rodents do not become bait-shy after once tasting warfarin; they continue to consume it until its anti-clotting properties have produced death through internal hemorrhaging. It can be used year-after-year wherever a rodent problem exists. Warfarin and its sodium salt are only slightly dangerous to humans and domestic animals when used as directed, but care must be taken with young pigs, which are especially susceptible. The sodium salt is also used to treat people with blood hypercoagulation problems. Registered for use in EU countries . Registered for use in the U.S.
Pharmazeutische Anwendungen
A group of naturally occurring antibiotics chemically related to the coumarin group of anticoagulants. The best known is novobiocin, but a few naturally occurring coumarins and some semisynthetic derivatives have been studied. They share a narrow range of antimicrobial activity largely directed against aerobic Gram-positive organisms. Novobiocin inhibits susceptible strains of Staph. aureus (including β-lactamaseproducing and methicillin-resistant strains), Str. pyogenes and Str. pneumonia at a concentration of 0.1–2 mg/L and it has been considered for the treatment of infection with multiresistant Staph. aureus and other Gram-positive cocci. However, since resistance arises readily and side effects are common, the general consensus is that it no longer has a place in antibacterial therapy.
There has been some revived interest in coumarins as potentiating agents of antineoplastic drugs.
Handelsname
ARAB RAT DETH®; ATROMBINE-K®; BRUMIN®; COMPOUND 42®; D-CON®; CO- RAX®; DETHMORE®; EAGLES-7®; EASTERN STATES DUOCIDE®; GROVEX SEWER BAIT®; HOPKINS BAR BAIR®; HOPKINS COV-R-TOX®; HOPKINS RODEX®; KILLGERM SEWARIN P®; KILMOL®; LIQUA-TOX®; MAR-FIN®; MOUSE PAK®; PLUSBAIT®; RAT-A-WAY®; RAT-B-GON®; RAT-O-CIDE®; RAT-GARD®; RAT & MICE BAIT®; RATRON®; RATS-NO-MORE®; RATTUNAL®; RAX®; RCR SQUIRREL KILLER®; RENTOKIL®; RENTOKIL BIOTROL®; RODEX BLOX®; RODENTEX®; RO- DETH®; RODEX®; ROUGH & READY MOUSE MIX®; SAKARAT®; SOLFARIN®; SOREXA PLUS®; SOREX CR1®; SEWARIN®; SPRAY-TROL BRANCH®; TWIN LIGHT RAT AWAY®; RODEN-TROL®; WARFARAT®; WARF COMPOUND®; VAMPIRINIP® Sodium Salt: ATHROMBIN®; LIQUA-TOX®; PANWARFIN®; RATSUL SOLUBLE®; TINTORANE®; VARFINE®; WARAN®; WARCOUMIN®; WARFILONE®
Sicherheitsprofil
A human poison by ingestion. Poison by inhalation and intravenous routes. Moderately toxic by skin contact, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: hemorrhage, ulceration or bleeding from small intestine, blood clotting factor change. Human reproductive effects by ingestion and intramuscular routes: fetal death and physical abnormalities at birth. Human teratogenic effects include developmental abnormalities of the craniofacial area, musculoskeletal system, and respiratory system. An experimental teratogen. Other experimental reproductive effects. Used as an oral anticoagulant and as a rodenticide. When heated to decomposition it emits acrid smoke and fumes.
mögliche Exposition
Warfarin is used as an oral anticoagulant and as a rodenticide or rat poison.
Erste Hilfe
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended.
Environmental Fate
Photolytic. Warfarin may undergo direct photolysis since the pesticide showed an absorption maximum of 330 nm (Gore et al., 1971)
Chemical/Physical. The hydrolysis half-lives at 68.0°C and pH values of 3.09, 7.11 and 10.18 were calculated to be 12.9, 57.4 and 23.9 days, respectively. At 25°C and pH 7, the half-life was estimated to be 16 years (Ellington et al., 1986)
Versand/Shipping
UN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
läuterung methode
dl-Warfarin crystallises from EtOH or MeOH. UV: max at 308nm ( 13,610) in H2O. The acetate has m 117-118o, the O-triflate has m 90-91o, and the 2,4-dinitrophenylhydrazone has m 215-216o. It is an effective anticoagulant and rodenticide. [West et al. J Am Chem Soc 83 2676 1961, HPLC: Banfield & Rowland J Pharm Sci 72 921 1983, Beilstein 17 III/IV 6794.] dl-Warfarin is resolved via recrystallisation of the quinidine salt, and the free acids are recrystallised (70g) from 600mL of 80% aqueous Me2CO. Large prismatic crystals of the pure enantiomers are obtained by slow crystallisation from Me2CO or AcOH. The solubilities of the pure enantiomers at 25o are 11.2% in Me2CO and 2.6% in AcOH, whereas the racemate has solubilities of 6.5% in Me2CO and 2% in AcOH. The IR spectra are the same with max (CHCl3) at 2.78 (w), 5.88, 6.16 and 6.38. [West et al. J Am Chem Soc 83 2676 1961, Cbz-proline diastereoisomeric esters were used for HPLC analysis: Banfield & Rowland J Pharm Sci 72 921 1983.] Poisonous, anticoagulant and rodenticide.
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Dust mixtures with air may cause explosion.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.
Warfarin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
4-Hydroxycumarin Salicylsäure Paraffinwachse und Kohlenwasserstoffwachse Toluol Natrium 2-(Acetyloxy)benzoesäure Getreide, Mehl Benzaldehyd Buten Thionyldichlorid Schwefelsure
Downstream Produkte
Bromadiolon 4-Hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(trifluormethylbenzyloxy)phe-nyl)-1-naphtyl)cumarin
Warfarin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 165)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32606 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688bruce@xrdchem.cn CHINA 548 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684info@tnjchem.com China 1737 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20177 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19975 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464
+49 3493/605470sales@intatrade.de Germany 3584 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-503281093bsc@sina.com China 15901 69
 
81-81-2(Warfarin)Verwandte Suche:
(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyron (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyron Warfarin Phenylvalerat Hymecromon 1-Benzopyran-2-on tert-Butyl-4-methoxyphenol Tetrahydro-4H-pyran-4-on 4-Hydroxycumarin 7-Hydroxycumarin Tetrahydropyran 3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure Phenylhydrazin Centchroman 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzo-pyran-2-on,Natrium-Salz 6-HYDROXYCOUMARIN 2,6-Di-tert-butyl-p-kresol Dicumarin
coumadin SAKARAT PROLIN(R) WARF COMPOUND 42(R) 1-(4’-hydroxy-3’-coumarinyl)-1-phenyl-3-butanone 1-(4’-hydroxy-3’coumarinyl)-1-phenyl-3-butanone 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone 200coumarin 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- 2H-1-Benzopyran-2-one,4-hydroxy-3-(3-oxo-1-phenylbutyl)-, 3-(2-Acetyl-1-phenylethyl)-4-hydroxycoumarin 3-(Acetonylbenzyl)-4-hydroxycoumarin 3-(alpha-acetonylbenzene)-4-hydroxycoumarin Arab rat deth arabratdeath arabratdeth Athrombine-K Athrombin-K athrombin-k/potassiumsalt/ Brumolin Compound 42 compound42 Co-rax coumadin/sodiumsalt/ maagrattentodcum marevan/sodiumsalt/ Mar-Frin martin’smar-frin Martin's mar-frin Maveran maveran/sodiumsalt/ Mouse pak mousepak prothromadin/sodiumsalt/ Rat & mice bait rat&micebait Rat-B-gon Rat-Gard Rat-Kill Rat-Mix Rat-o-cide No. 2 rat-o-cide#2 Rat-Ola Ratorex Ratox Ratoxin Ratron Ratron G ratrong Rats-no-more Ratten-Koederrohr Ratten-Koederrohr (German) Rattenstreupulver Neu Schacht Rattenstreupulver Neu Schacht (German) rattenstreupulvernewschacht Rattentraenke Rattentraenke (German) Rat-Trol
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