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Diethylphthalat Produkt Beschreibung

Diethyl phthalate  Struktur
84-66-2
CAS-Nr.
84-66-2
Bezeichnung:
Diethylphthalat
Englisch Name:
Diethyl phthalate
Synonyma:
Amozol;Anozol;Neantine;PHTHALOL;Solvanol;NSC 8905;estol1550;placidole;unimollda;Estol 1550
CBNumber:
CB3349654
Summenformel:
C12H14O4
Molgewicht:
222.24
MOL-Datei:
84-66-2.mol

Diethylphthalat Eigenschaften

Schmelzpunkt:
−3 °C(lit.)
Siedepunkt:
298-299 °C(lit.)
Dichte
1.12 g/mL at 25 °C(lit.)
Dampfdichte
7.66 (vs air)
Dampfdruck
1 mm Hg ( 100 °C)
Brechungsindex
n20/D 1.502(lit.)
Flammpunkt:
>230 °F
storage temp. 
2-8°C
Löslichkeit
Practically insoluble in water, miscible with ethanol (96 per cent).
Aggregatzustand
Liquid
Wichte
1.118
Farbe
APHA: ≤15
Explosionsgrenze
0.75%, 187°F
Wasserlöslichkeit
1 g/L (20 ºC)
Merck 
14,7371
BRN 
1912500
Henry's Law Constant
At 25 °C: 5.01, 4.54, 4.78, 4.94, 2.21, and 2.44 (x 10-5 atm?m3/mol)at pH values of 2.96, 2.98, 6.18, 6.19, 8.98, and 9.00, respectively (Hakuta et al., 1977).
Expositionsgrenzwerte
TLV-TWA air 5 mg/m3 (ACGIH). .
Stabilität:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, alkalies.
CAS Datenbank
84-66-2(CAS DataBase Reference)
NIST chemische Informationen
Diethyl phthalate(84-66-2)
EPA chemische Informationen
1,2-Benzenedicarboxylic acid, diethyl ester(84-66-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 24/25
RIDADR  UN 3082 9 / PGIII
WGK Germany  2
RTECS-Nr. TI1050000
Selbstentzündungstemperatur 854 °F
TSCA  Yes
HS Code  29173400
Giftige Stoffe Daten 84-66-2(Hazardous Substances Data)
Toxizität LD50 i.p. in rats: 5.06 ml/kg (Singh)
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

Diethylphthalat Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE, öLIGE FLüSSIGKEIT.

CHEMISCHE GEFAHREN

Zersetzung beim Erhitzen oder beim Verbrennen unter Bildung giftiger Rauche und Gase (Phthalsäureanhydrid - s. ICSC 0315). Greift einige Kunststoffarten an.

ARBEITSPLATZGRENZWERTE

TLV: 5 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

INHALATIONSGEFAHREN

Beim Verdampfen bei 20°C tritt eine gesundheitsschädliche Kontamination der Luft nicht oder nur sehr langsam ein

LECKAGE

Persönliche Schutzausrüstung: Atemschutzgerät mit Partikelfilter entsprechend der Arbeitsplatzkonzentration des Stoffes. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Umwelt gelangen lassen.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Diethyl phthalate is a colourless, odourless, and oily liquid. It is miscible with ethanol and ethyl ether. Diethyl phthalate is soluble in acetone, benzene, carbon tetrachloride, alcohols, ketones, esters, and aromatic hydrocarbons and partly miscible with aliphatic solvents. Diethyl phthalate, when exposed to heat, decomposes and emits acrid smoke and irritating fumes. It is incompatible with strong oxidisers, strong acids, nitric acid, permanganates, and water and attacks some forms of plastics. Diethyl phthalate is produced in the reaction of phthalic anhydride with ethanol in the presence of concentrated sulphuric acid catalyst.

Chemische Eigenschaften

Diethyl phthalate is a clear, colorless, oily liquid. It is practically odorless, or with a very slight aromatic odor and a bitter, disagreeable taste.

Physikalische Eigenschaften

Clear, colorless, oily liquid with a mild, chemical odor. Bitter taste.

Verwenden

Diethyl phthalate has been used as a substitute for camphor in the manufacture of celluloid, as a solvent for cellulose acetate in the manufacture of varnishes and dopes, as a ftxative for perfumes, and for denaturing ethanol.

Verwenden

A phthalate metabolite with genotoxic effect.

Verwenden

Plasticizer.

Verwenden

Ethyl phthalate used in manufacture of celluloid; solvent for cellulose acetate in manufacture of varnishes and dopes; denaturing alcohol. Vehicle for fragrance and cosmetic ingredients.

Definition

ChEBI: The diethyl ester of benzene-1,2-dicarboxylic acid.

Vorbereitung Methode

Diethyl phthalate is produced by the reaction of phthalic anhydride with ethanol in the presence of sulfuric acid.

Allgemeine Beschreibung

A clear, colorless liquid without significant odor. More dense than water and insoluble in water. Hence sinks in water. Primary hazard is to the environment. Spread to the environment should be immediately stopped. Easily penetrates soil, contaminates groundwater and nearby waterways. Flash point 325°F. Severely irritates eyes and mildly irritates skin. Used in the manufacture of perfumes, plastics, mosquito repellents and many other products.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

Diethyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].

Health Hazard

Symptoms unlikely from any form of exposure.

Health Hazard

Diethyl phthalate exhibited low to very lowacute toxicity in laboratory animals. Inges tion produced somnolence and hypotension.Inhalation of its vapors may result in lacrima tion, coughing, and irritation of the throatin humans. The oral LD50 value in mice is6170 mg/kg. Diethyl phthalate administeredto pregnant rats at 5% concentration in thefeed showed no adverse effect upon embryoor fetal growth, viability, or the incidence ofmalformations (Price et al. 1988).

Brandgefahr

Special Hazards of Combustion Products: Irritating vapors of unburned chemical may form in fire.

Pharmazeutische Anwendungen

Diethyl phthalate is used as a plasticizer for film coatings on tablets, beads, and granules at concentrations of 10–30% by weight of polymer.
Diethyl phthalate is also used as an alcohol denaturant and as a solvent for cellulose acetate in the manufacture of varnishes and dopes. In perfumery, diethyl phthalate is used as a perfume fixative at a concentration of 0.1–0.5% of the weight of the perfume used.

Kontakt-Allergie

This plasticizer increases the fexibility of plastics. It is also contained in deodorant formulations, perfumes, emollients, and insect repellents. It can cross-react with dimethyl phthalate.

Sicherheitsprofil

Poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. Human systemic effects by inhalation: lachrymation, respiratory obstruction, and other unspecified respiratory system effects. An eye irritant and systemic irritant by inhalation. An experimental teratogen. Other experimental reproductive effects. Narcotic in hgh concentrations. Combustible when exposed to heat or flame. To fight fire, use water spray, mist, foam. When heated to decomposition it emits acrid smoke and irritating fumes.

Sicherheit(Safety)

Diethyl phthalate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, if consumed in large quantities it can act as a narcotic and cause paralysis of the central nervous system.
Although some animal studies have suggested that high concentrations of diethyl phthalate may be teratogenic, other studies have shown no adverse effects.
LD50 (guinea pig, oral): 8.6g/kg
LD50 (mouse, IP): 2.7g/kg
LD50 (mouse, oral): 6.2g/kg
LD50 (rat, IP): 5.1g/kg
LD50 (rat, oral): 8.6g/kg

Source

Leaching from PVC piping in contact with water (quoted, Verschueren, 1983).

Environmental Fate

Biological. A proposed microbial degradation mechanism is as follows: 4-hydroxy-3- methylbenzyl alcohol to 4-hydroxy-3-methylbenzaldehyde to 3-methyl-4-hydroxybenzoic acid to 4-hydroxyisophthalic acid to protocatechuic acid to β-ketoadipic acid (Chapman, 1972). In anaerobic sludge, diethyl phthalate degraded as follows: monoethyl phthalate to phthalic acid to protocatechuic acid followed by ring cleavage and mineralization (Shelton et al., 1984).
Photolytic. An aqueous solution containing titanium dioxide and subjected to UV radiation (λ >290 nm) produced hydroxyphthalates and dihydroxyphthalates as intermediates (Hustert and Moza, 1988).
Chemical/Physical. Under alkaline conditions, diethyl phthalate will initially hydrolyze to ethyl hydrogen phthalate and ethanol. The monoester will undergo hydrolysis forming o-phthalic acid and ethanol (Kollig, 1993). A second-order rate constant of 2.5 x 10-2/M?sec was reported for the hydrolysis of diethyl phthalate at 30 °C and pH 8 (Wolfe et al., 1980). At 30 °C, hydrolysis halflives of 8.8 and 18 yr were reported at pH values 9 and 10-12, respectively (Callahan et al., 1979).

Lager

Diethyl phthalate is stable when stored in a well-closed container in a cool, dry place.

läuterung methode

Wash the ester with aqueous Na2CO3, then distilled water, dry (CaCl2), and distil it under reduced pressure. Store it in a vacuum desiccator over P2O5. [Beilstein 9 IV 3172.]

Inkompatibilitäten

Incompatible with strong oxidizing materials, acids, and permanganates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, delayed action, enteric coated, and sustained action tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Diethylphthalat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diethylphthalat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 299)Lieferanten
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84-66-2(Diethylphthalat)Verwandte Suche:


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