Triethylphosphonoacetat
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- CAS-Nr.
- 867-13-0
- Bezeichnung:
- Triethylphosphonoacetat
- Englisch Name:
- Triethyl phosphonoacetate
- Synonyma:
- ETHYL 2-(DIETHOXYPHOSPHORYL)ACETATE;ETHYL DIETHYLPHOSPHONOACETATE;Triethyl phosphonacetate;Ticagrelor Impurity 150;Triethyl phosphonoacetat;CarbethoxyMethyldiethyl Phosphonate;DIETHYLPHOSPHONOACETIC ACID ETHYL ESTER;DIETHYL ETHOXYCARBONYLMETHYLPHOSPHONATE;tl465;NSC 13898
- CBNumber:
- CB3487949
- Summenformel:
- C8H17O5P
- Molgewicht:
- 224.19
- MOL-Datei:
- 867-13-0.mol
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Triethylphosphonoacetat Eigenschaften
- Schmelzpunkt:
- -24°C
- Siedepunkt:
- 142-145 °C9 mm Hg(lit.)
- Dichte
- 1.13 g/mL at 25 °C(lit.)
- Dampfdruck
- 0.61Pa at 25℃
- Brechungsindex
- n20/D 1.431(lit.)
- Flammpunkt:
- 165°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- Aggregatzustand
- Liquid
- Wichte
- 1.130
- Farbe
- Clear
- Wasserlöslichkeit
- Slightly miscible with water.
- BRN
- 1343714
- InChIKey
- GGUBFICZYGKNTD-UHFFFAOYSA-N
- LogP
- 1.13 at 30℃
- CAS Datenbank
- 867-13-0(CAS DataBase Reference)
- EPA chemische Informationen
- Acetic acid, (diethoxyphosphinyl)-, ethyl ester (867-13-0)
Triethylphosphonoacetat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Triethyl phosphonoacetate is a reagent for organic synthesis used in the Horner-Wadsworth-Emmons reaction (HWE) or the Horner-Emmons modification. This compound can be added dropwise to sodium methoxide solution to prepare a phosphonate anion. It has an acidic proton that can easily be abstracted by a weak base. When used in an HWE reaction with a carbonyl, the resulting alkene formed is usually the E alkene and is generated with excellent regioselectivity. It can synthesize β-Keto Phosphonates via an acylation reaction of triethyl phosphonoacetate with carboxylic acid chlorides in the presence of magnesium chloride-triethylamine followed by decarbethoxylation. Acylation of triethyl phosphonoacetate using magnesium ethoxide affords acyl phosphonoacetates, which, on treatment with catalytic p-TsOH in water, are converted into 2-aryl-2-oxoalkylphosphonates[1-2].
Chemische Eigenschaften
Triethyl phosphonoacetate is Colorless to light yellow liqui
Verwenden
Triethyl phosphonoacetate serves as a reactant used in Horner-Wadsworth-Emmons reactions, Tsuji-Trost type reactions, Intramolecular Heck-type cyclization and isomerizations and Intramolecular aryne-ene reactions. In Horner-Wadsworth-Emmons reaction, it is utilized as a reagent to prepare chiral 2-methylcyclopropanecarboxylic acid from (S)-propylene oxide.
läuterung methode
Purify it by fractional distillation, preferably in vacuo. NMR has P resonance at 19.5 relative to orthophosphate. [Kosolapoff & Powell J Am Chem Soc 68 1103 1946, Kosolapoff & Powell J Am Chem Soc 72 4198 1950, Speziale & Freeman J Org Chem 23 1586 1958, Beilstein 4 IV 3613.]
Triethylphosphonoacetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Triethylphosphonoacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 529)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
|
Jiangxi Sunway Chemical Co., Ltd.
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+86-0794-5259909 +8615888611133
|
dave@jxswchem.com |
China |
22 |
58 |
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Jiangxi Sunway Chemical Co., Ltd.
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+86-0794-5259909 +8615888611133
|
dave@jxswchem.com |
China |
22 |
58 |
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Hebei Mojin Biotechnology Co., Ltd
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+8613288715578
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sales@hbmojin.com |
China |
12453 |
58 |
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Hebei Yanxi Chemical Co., Ltd.
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+8617531190177
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peter@yan-xi.com |
China |
5993 |
58 |
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Henan Fengda Chemical Co., Ltd
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+86-371-86557731 +86-13613820652
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info@fdachem.com |
China |
7377 |
58 |
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Capot Chemical Co.,Ltd.
|
571-85586718 +8613336195806
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sales@capotchem.com |
China |
29797 |
60 |
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Shanghai Daken Advanced Materials Co.,Ltd
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+86-371-66670886
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info@dakenam.com |
China |
15371 |
58 |
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Henan Tianfu Chemical Co.,Ltd.
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+86-0371-55170693 +86-19937530512
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info@tianfuchem.com |
China |
21695 |
55 |
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Hangzhou FandaChem Co.,Ltd.
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008657128800458; +8615858145714
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fandachem@gmail.com |
China |
9352 |
55 |
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Nanjing ChemLin Chemical Industry Co., Ltd.
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025-83697070
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product@chemlin.com.cn |
CHINA |
3012 |
60 |
867-13-0(Triethylphosphonoacetat)Verwandte Suche:
- AURORA KA-1452
- ETHOXYCARBONYLMETHANEPHOSPHONIC ACID DIETHYL ESTER
- DIETHYL ETHOXYCARBONYLMETHANEPHOSPHONATE
- PHOSPHONOACETIC ACID TRIETHYL ESTER
- O,O-DIETHYL ETHOXYCARBONYLMETHYL PHOSPHONATE
- ethyldiethoxyphosphorylacetate
- phosphono-aceticacitriethylester
- tl465
- Triethylphosphonaceticacid
- PhosPhonoacetic acid ethyl ester
- Triethyl Phosphonoaceate
- Triethylphosphonoacetate98%
- Trietyl Phosphonoacetate
- TRIETHYLPHOSPHONEACETATE
- Diethyl((ethoxycarbonyl)methyl)phosphonate, 98+ %
- (diethoxyphosphinyl)-aceticaciethylester
- TRIETHYL PHOSPHONOACTETATE
- TRIETHYL PHOSPHONOACETATE
- TRIETHYL CARBOXYMETHYLPHOSPHONATE
- Aceticacid,(diethoxyphosphinyl)-,ethylester
- diethylphosphono-aceticaciethylester
- ethyl(diethoxyphosphinyl)acetate
- Ethyl(diethyoxyphosphoryl)acetate
- Diethyl ethoxycarbonylmethylphosphonate, Triethyl carboxymethylphosphonate
- Ethyl Diethylphosphoneacetate
- Triethyl phosphonoac
- Triethyl phosphonoacetate, Ethyl (diethoxyphosphoryl)acetate
- Triethyl phosphonoacetate, 97% 100GR
- (Diethoxyphosphinyl)acetic acid ethyl
- 2-Oxo-2-ethoxyethylphosphonic acid diethyl ester
- Diethoxyphosphinylacetic acid ethyl
- Diethoxyphosphinylacetic acid ethyl ester
- Ethoxycarbonylmethylphosphonic acid diethyl ester
- Acetic acid, phosphono-, triethyl ester
- TRIETHYL PHOSPHONOACETATE ,97%
- Triethyl phosphonoacetate,98.5%
- 2-(Diethoxyphosphinyl)acetic Acid Ethyl Ester
- NSC 13898
- NSC 16128
- Acetic acid, 2-(diethoxyphosphinyl)-, ethyl ester
- Triethyl phosphonoacetate(TEPP)
- Diethylphosphonoacetic Acid Ethyl Ester
Phosphonoacetic Acid Triethyl Ester
Ethyl Diethylphosphonoacetate
- Phosphoryl three ethyl acetate
- Ethyl 2-(diethoxyphosphoryl)acetate? (Ticagrelor Impurity)
- Triethyl phosphonylacetate
- Triethyl Phosphonoacetate >
- Triethyl phosphonoacetate, 98%, for synthesis
- (Diethoxy-phosphoryl)-acetic acid ethyl ester
- ETHYL 2-(DIETHOXYPHOSPHORYL)ACETATE
- ETHYL DIETHYLPHOSPHONOACETATE
- Triethyl phosphonacetate
- CarbethoxyMethyldiethyl Phosphonate
- Triethyl phosphonoacetat
- DIETHYLPHOSPHONOACETIC ACID ETHYL ESTER
- DIETHYL ETHOXYCARBONYLMETHYLPHOSPHONATE
- Ticagrelor Impurity 150
- TEPA (TRIETHYL PHOSPHONO ACETATE)
- 867-13-0
