Ethyl-chloracetat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT STECHENDEM GERUCH.
PHYSIKALISCHE GEFAHREN
Die Dämpfe sind schwerer als Luft.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger und ätzender Gase mit Chlorwasserstoffund Essigsäurerauchen. Reagiert mit Wasser, feuchter Luft und Säuren unter Bildung von Chlorwasserstoff (s. ICSC-Nr. 0163). Reagiert mit Basen, Oxidationsmitteln und Reduktionsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt stark die Augen, und reizt leicht die Haut und die Atemwege.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen.
LECKAGE
Zündquellen entfernen. Ausgelaufene Flüssigkeit in abgedeckten Kunststoffbehältern sammeln. Reste mit trockenem Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R50:Sehr giftig für Wasserorganismen.
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S7/9:Behälter dicht geschlossen an einem gut gelüfteten Ort aufbewahren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
Ethyl chloroacetate is a colourless liquid with a pungent, fruity odor.Ethyl chloroacetate has a vapor pressure of 10mmHg at 38 °C (Lewis, 1997). It is insoluble in water, but miscible with alcohol, ether, and acetone (Lide, 1998); it is soluble in benzene (Lewis, 1997). Ethyl chloroacetate readily decomposes in hot water and alkalis (Lewis, 1997).
Verwenden
Ethyl chloroacetate is a reagent used in the preparation of 5 member heterocycles. It is used as pharmaceutical and organic intermediate. It is used as a solvent for organic synthesis and the production of pesticides (such as sodium fluoroacetate).
synthetische
Ethyl chloroacetate is synthesized by esterification of chloroacetic acid and ethanol under the catalysis of sulfuric acid. The reaction equation is as follows:
ClCH2COOH+C2H5OH[H2SO4]→ClCH2COOC2H5+H2O
Reaction: Add chloroacetic acid, ethanol and benzene into the esterification pot, turn on the stirrer, slowly add sulfuric acid, heat to reflux, continuously steam out the benzene-water azeotrope, and de-esterify the water generated by condensation and separator layering, Benzene is refluxed into the esterification pot, cooled and discharged when there is no more water to steam out, the crude ester is washed with saturated sodium bicarbonate solution and water to neutrality, dried with anhydrous calcium chloride, distilled, and collected The fraction at 144-146°C is the finished product of ethyl chloroacetate, the content is ≥99.0%, and the yield is 85%.
Allgemeine Beschreibung
A clear colorless liquid with a pungent odor. Flash point 100°F. Denser than water and insoluble in water. Vapors heavier than air.
Air & Water Reaktionen
Highly flammable. Slow hydrolysis to acidic products will cause slow corrosion of common metals. No hazard involved. [USCG, 1999].
Reaktivität anzeigen
Ethyl chloroacetate is a chlorinated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Hazard
Strong irritant to eyes.
Health Hazard
Inhalation causes irritation of mucous membrane, headache, and nausea. Contact with liquid causes extreme eye irritation and conjunctivitis; irritates skin if not removed at once. Ingestion causes irritation of mouth and stomach.
Brandgefahr
Special Hazards of Combustion Products: Irritating, toxic hydrogen chloride and phosgene may be generated in fires.
Chemische Reaktivität
Reactivity with Water Very slow, not hazardous; Reactivity with Common Materials: Slow hydrolysis to acidic products; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Sicherheitsprofil
oison by skin contact
and subcutaneous routes. A severe eye
irritant. Questionable carcinogen with
experimental neoplastigenic data.Flammable liquid; a dangerous fire hazard
when exposed to heat or flame; can react
vigorously with oxidizing materials. Will
react with water or steam to produce toxic
and corrosive fumes. Vigorous reaction with
sodium cyanide. To fight fire, use water,
foam, CO2, dry chemical. When heated to
decomposition it emits highly toxic fumes of
cl-.
mögliche Exposition
Used to make rodenticides, dyes, and
other chemicals. Also used as a military poison
Versand/Shipping
UN1181 Ethylchloroacetate, Hazard class: 6.1;
Labels: 6.1-Poisonous materials, 3-Flammable liquid.
läuterung methode
Shake the ester with satutated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times) and saturated aqueous NaCl (twice). Dry it with Na2SO4 or MgSO4 and distil it. [Beilstein 2 IV 481.] LACHRYMATORY.
Inkompatibilitäten
May form explosive mixture with air.
Incompatible with strong bases; strong acids; reducing
agents. Moisture, water, and steam contact forms toxic and
corrosive fumes. Violent reaction with oxidizers, alkaline
earth metals (barium, calcium, magnesium, strontium, etc.),
alkaline metals, sodium cyanide. Attacks metals in the presence of moisture.
Waste disposal
Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal,
state, and local environmental regulations must be
observed. Consult with environmental regulatory agencies
for guidance on acceptable disposal practices. Generators
of waste containing this contaminant (≥100 kg/mo) must
conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Ethyl-chloracetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Hydratropaldehyd
Ethyl-[[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetathydrochlorid
N-ethyl perfluorooctylsulfonylaminoacetate
3-(1，1-dimethylethyl)-5-(ethoxycarboxy)-methylthio-1，2，4-triazole
(4-OXO-6,7-DIHYDRO-4H,5H-CYCLOPENTA[4,5]THIENO-[2,3-D]PYRIMIDIN-3-YL)-ACETIC ACID
Piroxicam
2-(4-Isobutylphenyl)propionaldehyd
1-(Hydrazinocarbonylmethyl)pyridiniumchlorid
7-Methoxybenzofuran-2-carboxylic acid
Piracetam
4-(ACETYLAMINO)PHENOXYACETIC ACID ETHYL ESTER
2-Methylundecanal
ETHYL 3-(4-ISOBUTYLPHENYL)-3-METHYL GLYCIDATE
Menazon
6-Bromoindole-2-carboxylic acid
Ethylfluoracetat
1-Boc-3-oxopiperazine
2-Piperazinone
Etomidat
ETHYL 5-BROMOTHIOPHENE-2-CARBOXYLATE
2-Imino-1,3-thiazol-4-on
2-(4-Isobutylphenyl)propionaldehydoxim
SODIUM 3-4-ISOBUTYLPHENYL)-2,3-EPOXYBUTYURATE
Ethyl 6-bromoindole-2-carboxylate
Ethyl-3-phenyloxiran-2-carboxylat
2-Chloracetamid
5-Bromothiophene-2-carbohydrazide
Cloricromene
(6-ETHYL-4-OXO-4H-THIENO[2,3-D]PYRIMIDIN-3-YL)-ACETIC ACID
6-AMINO-CHROMEN-2-ONE
7-PROPOXY-CHROMEN-2-ONE
1-(((5-Nitro-2-furanyl)methylen)-amino)-2,4-imidazolidindion
A-METHYL-3-PHENOXYBENZENEACETALDEHYDE
Vitamin-A-alkohol
Triethylethan-1,1,2-tricarboxylat
Ethyl 2-aminothiazole-5-carboxylate
Methyl-3-methyl-2-butenoat
Ethyl-2,3-epoxy-3-phenylbutyrat
2-(2-thienyl)propionic acid
(Hydrazinocarbonylmethyl)trimethylammoniumchlorid
