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Clidiniumbromid Produkt Beschreibung

Clidinium bromide Struktur
3485-62-9
CAS-Nr.
3485-62-9
Bezeichnung:
Clidiniumbromid
Englisch Name:
Clidinium bromide
Synonyma:
QUARZAN;Ro-3773;Clidinium;RO-2-3773;quarzanbromide;CLIDINIUM BROMIDE;Clidinium Brimide;Clidinium iodide D3;Clidinium Bromide (2 g);Clidinium Bromide (500 mg)
CBNumber:
CB5419496
Summenformel:
C22H26BrNO3
Molgewicht:
432.35
MOL-Datei:
3485-62-9.mol

Clidiniumbromid Eigenschaften

Schmelzpunkt:
240-241°C
storage temp. 
Inert atmosphere,Room Temperature
Aggregatzustand
neat
CAS Datenbank
3485-62-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
S-Sätze: 36
RIDADR  3249
WGK Germany  3
RTECS-Nr. VD6125000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

Clidiniumbromid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes). Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice. This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.

Chemische Eigenschaften

White Crystalline Solid

Originator

Librax,Roche,US,1961

Verwenden

An anticholinergic. Used as an antispasmodic

Verwenden

An anticholinergic. Used as an antispasmodic.

Definition

ChEBI: The bromide salt of clinidium. It is used for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.

Manufacturing Process

5.12 g of 1-azabicyclo[2.2.2]-3-octanol were refluxed with a suspension of 0.92 g of finely divided sodium in 50 cc of toluene, until most of the sodium had reacted (about 4 hours). The thus obtained suspension of the white amorphous alcoholate was cooled with ice, and reacted with 10.16 g of diphenylchloroacetyl chloride, which was added in form of a solution in approximately 40 cc of toluene. The mixture was stirred for 1 hour at room temperature. Small amounts of unreacted sodium were destroyed with isopropanol, and 120 cc of 1 N hydrochloric acid were then added, The mixture was refluxed for 1/2 hour, in order to convert the first formed product, diphenylchloroacetic acid ester of 1-azabicyclo[2.2.2]-3-octanol, into the corresponding benzilic acid ester.
The toluene phase was separated and discarded. The aqueous phase, together with a precipitated water- and toluene-insoluble oil, was made alkaline and extracted repeatedly with chloroform. The chloroform solution was concentrated in vacuo. The residue was recrystallized from a mixture of acetone and ether (alternatively, from chloroform and ether), and formed needles melting at 164° to 165°C. It was identified as 3-benziloyloxy-1- azabicyclo[2.2.2]octane.
3-Benziloyloxy-1-azabicyclo[2.2.2]octane methobromide was prepared by adding 20 cc of a 30% solution of methyl bromide in ether to a solution of 2.5 g of 3-benziloyloxy-1-azabicyclo[2.2.2]octane in 20 cc of chloroform. After standing for 3 hours at room temperature and 15 hours at +5°C, a crystalline precipitate had formed. This was filtered off and recrystallized from a mixture of methanol, acetone, and ether; prisms melting at 240° to 241°C.

Trademarks

Quarzan (Roche).

Therapeutic Function

Anticholinergic, Antiulcer

Allgemeine Beschreibung

Clidinium bromide, 3-hydroxy-1-methylquinuclidinium bromide benzilate (Quarzan),is a white or nearly white, almost odorless, crystalline powderthat is optically inactive. It is soluble in water and alcohol butonly very slightly soluble in ether and benzene.

Clinical Use

This anticholinergic agent is marketed alone and in combinationwith the minor tranquilizer chlordiazepoxide (Librium)in a product known as Librax. The rationale of the combinationfor the treatment of GI complaints is the use of an anxiety-reducing agent together with an anticholinergic agent,based on the recognized contribution of anxiety to the developmentof the diseased condition. It is suggested for pepticulcer, hyperchlorhydria, ulcerative or spastic colon, anxietystates with GI manifestations, nervous stomach, irritable orspastic colon, and others. Clidinium bromide is contraindicatedin glaucoma and other conditions that may be aggravatedby the parasympatholytic action, such as prostatic hypertrophyin elderly men, which could lead to urinary retention.

Clidiniumbromid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Clidiniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 106)Lieferanten
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ATK CHEMICAL COMPANY LIMITED
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career henan chemical co
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008657185134895 info@afinechem.com CHINA 15559 58
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Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9465 58

3485-62-9(Clidiniumbromid)Verwandte Suche:


  • CLIDINIUM BROMIDE
  • 3-[(HYDROXYPHENYLACETYL)OXY]-1-METHYL-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE
  • 3-HYDROXY-1-METHYLQUINUCLIDINIUM BROMIDE BENZILATE
  • QUARZAN
  • RO-2-3773
  • quinuclidinolmethylbromide,benzilate
  • 3-[(Hydroxyphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2,2,2]octane Bromide, Ro-2-3773, Quarzan
  • Clidinium
  • (1-Methyl-1-azoniabicyclo[2.2.2]octan-8-yl) 2-hydroxy-2,2-diphenylacetate bromide
  • 1-Azoniabicyclo[2.2.2]octane, 3-[(hydroxydiphenylacetyl)oxy]-1-methyl-, bromide
  • 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide
  • Ro-3773
  • 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane
  • Clidinium Brimide
  • Clidinium Bromide (500 mg)
  • Clidinium Bromide (2 g)
  • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-Methyl-1-azabicyclo[2.2.2]octan-1-iuM broMide
  • Clidinium iodide D3
  • 1-methyl-3-benzil-oxyloxy-quinuclidiniumbromide
  • 3-((hydroxydiphenylacetyl)oxy)-1-methyl-1-azoniabicyclo(2.2.2)octanbromi
  • 3-(2,2-diphenyl-2-hydroxyethanoyloxy)-quinuclidiniumbromide
  • 3-(benziloyloxy)-1-methylquinuclidiniumbromide
  • benzilicacid,esterwith3-hydroxy-1-methylquinuclidinium
  • quarzanbromide
  • quinuclidinium,3-hydroxy-1-methyl-,bromide,benzilate
  • 2-hydroxy-2,2-diphenylacetic acid (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) ester bromide
  • 3-(2-Hydroxy-2,2-diphenylacetoxy)-1-methylquinuclidin-1-ium bromide
  • 3485-62-9
  • C22H26NO3Br
  • C22H26BO3Rn
  • C22H26BrNO3
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