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Dorzolamide Hydrochloride Produkt Beschreibung

Dorzolamide Hydrochloride Struktur
130693-82-2
CAS-Nr.
130693-82-2
Englisch Name:
Dorzolamide Hydrochloride
Synonyma:
MK 507;mk-0507;Trusopt;Biosopt;L 671152;Dorzalamide;DORZOLAMIDE HCL;Dorzolamide HCI;DorzolomideHcl,Usp;MK507 hydrochloride
CBNumber:
CB7296763
Summenformel:
C10H17ClN2O4S3
Molgewicht:
360.9
MOL-Datei:
130693-82-2.mol

Dorzolamide Hydrochloride Eigenschaften

Schmelzpunkt:
265-2670C
alpha 
D24 -8.34° (c = 1 in methanol)
storage temp. 
Refrigerator
Löslichkeit
Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol.
Aggregatzustand
neat
maximale Wellenlänge (λmax)
254nm(CHCl3:MeOH= aq.)(lit.)
Merck 
14,3426
BRN 
5896026
CAS Datenbank
130693-82-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. XJ9095163
HS Code  2935904000
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Dorzolamide Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Dorzolamide hydrochloride was introduced in the U.S.A. as eye drops for the treatment of open-angle glaucoma and ocular hypertension. Dorzolamide is a potent carbonic anhydrase inhibitor that, on topical administration, lowers intraocular pressure (IOP). In a clinical study in patients with bilateral primary open-angle glaucoma or ocular hypertension, dorzolamide (0.7-2%) was found to significantly lower IOP throughout the day. Dorzolamide has been shown to be effective as a single therapy or in combination with β-blockers.

Chemische Eigenschaften

White Powder

Originator

Merck (U.S.A.)

Verwenden

Carbonic anhydrase inhibitor. Antiglaucoma agent.

Verwenden

Antiglaucoma drug;Carbonic anhydrase inhibitor

Verwenden

analgesic

Verwenden

Dorzolamide HCl Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Verwenden

An inhibitor of carbonic anhydrase.

Definition

ChEBI: The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.

Trademarks

Trusopt (Merck).

Veterinary Drugs and Treatments

Dorzolamide is often used in the contralateral eye of a dog with primary glaucoma to prevent development of bilateral disease. It is also an excellent agent to consider for most secondary glaucomas in dogs and cats because it has no effect on pupil size. Like the related oral carbonic anhydrase inhibitors (dichlorphenamide or Daranide?, methazolamide or Neptazane?), dorzolamide decreases aqueous humor production by the ciliary body epithelium by altering pH and affecting the H+/Na+ active transport exchange mechanism. Oral carbonic anhydrase inhibitors cause numerous systemic side effects such as metabolic acidosis and panting, diarrhea, vomiting, anorexia and others, all of which can be avoided with topical carbonic anhydrase inhibitors.

Dorzolamide Hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dorzolamide Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 200)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21745 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 294 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3193 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6370 58

130693-82-2()Verwandte Suche:


  • 3-b)thiopyran-2-sulfonamide,5,6-dihydro-4-(ethylamino)-6-methyl-4h-thieno(
  • mk-0507
  • monohydrochloride,(4s-trans)-7-dioxide
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride
  • MK-507 (L-671152) HCl
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride (1:1), (4S,6S)-
  • Dorzolomide hydrochloride, >=99%
  • (4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxid
  • L671152 hydrochloride
  • MK507 hydrochloride
  • Trusopt hydrochloride
  • Doosamine hydrochloride
  • (4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
  • (2s,4s)-2-ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide hydrochloride
  • DORZOLAMIDE HCL
  • DORZOLAMIDE HYDROCHLORIDE
  • dorzolomide hydrochloride
  • DorzolomideHcl,Usp
  • DORZOLAMIDEHYDROCHLORIDE(SUBJECTTOPATENTFREE)
  • (S,S)-(-)-5,6-Dihydro-4-ethylamino-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide monohydrochloride
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S,6S)-
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S-trans)-
  • L 671152
  • MK 507
  • Trusopt
  • Dorzolamide HCI
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,
    6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S,6S)
  • (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-β]thiopyran-2-sulfonamide 7,7-Dioxide Hydrochloride
  • Dorzalamide
  • (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide Hydrochloride
  • DorzolaMide Hydrochloride, USP
  • Dorzolamide Hydrochloride (200 mg)
  • Biosopt
  • Dorzolamide For System Suitability EPCR
  • 130693-82-2
  • C10H16N2O4S3HCl
  • C10H16N2O4S3ClH
  • C10H17ClN2O4S3
  • Inhibitors
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Dorzolamide
  • Heterocycles
  • Sulfur & Selenium Compounds
  • API
  • Trusopt, Cosopt
  • Other APIs
  • -
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