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3β-Hydroxyurs-12-en-28-sure Produkt Beschreibung

Ursolic acid Struktur
77-52-1
CAS-Nr.
77-52-1
Bezeichnung:
3β-Hydroxyurs-12-en-28-sure
Englisch Name:
Ursolic acid
Synonyma:
MALOL;URSON;UrsoL;PRUNOL;Ursolic;NSC-4060;Masterin;Merotaine;Neoage UR;MICROMEROL
CBNumber:
CB7470516
Summenformel:
C30H48O3
Molgewicht:
456.71
MOL-Datei:
77-52-1.mol

3β-Hydroxyurs-12-en-28-sure Eigenschaften

Schmelzpunkt:
292 °C (dec.) (lit.)
alpha 
59 º (c=0.3, pyridine)
Siedepunkt:
502.79°C (rough estimate)
Dichte
1.0261 (rough estimate)
Brechungsindex
1.4940 (estimate)
storage temp. 
2-8°C
Aggregatzustand
Crystalline Powder or Needles
pka
4.68±0.70(Predicted)
Farbe
White to off-white
Wasserlöslichkeit
insoluble
Merck 
14,9890
BRN 
2228563
CAS Datenbank
77-52-1(CAS DataBase Reference)
EPA chemische Informationen
Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)- (77-52-1)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 24/25-36-26
WGK Germany  -
RTECS-Nr. YU9520000
10-23
HS Code  29181990
Giftige Stoffe Daten 77-52-1(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H413 Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 4
Sicherheit

3β-Hydroxyurs-12-en-28-sure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

white to light yellow crystal powde

Verwenden

A Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties.

Verwenden

ursolic acid helps maintain the look and feel of the skin, acts as a perfume and helps mask odor. Therapeutic benefits in skin care include anti-inflammatory activity. ursolic acid has demonstrated anti-microbial, anti-bacterial, and anti-fungal action as well.

Definition

ChEBI: A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.

Anticancer Research

It is a triterpenoid, derived from basil, and suppresses the activation of NF-κB byinhibiting a kinase that activates NF-κB(IKK) (Aggarwal and Shishodia 2004). It suppresses tumorigenesis, tumor promotion, and angiogenesis by downregulationof the expression of lipoxygenases (LOX), MMP-9, and COX-2. It is reported toinduce apoptosis in breast cancer, melanoma, hepatoma, prostate cancer, andacute myelogenous leukemia by preventing replication of DNA, inhibition of proteintyrosine kinases, activation of caspases, induction of calcium release, anddownregulating apoptosis gene cellular inhibitor. Ursolic acid inhibits IκBαkinase activity, degradation of IκBα, phosphorylation, NF-κB-dependent reportergene expression, p65 nuclear translocation, and p65 phosphorylation. Inhibitionof NF-κB leads to the reduction of cyclin D1, COX-2, and MMP9 expression.This downregulates STAT-3 activation and its regulated gene products such ascyclin D1, Mcl-1, Bcl-xL, survivin, Bcl-2, and VEGF. It also induces the expressionof tyrosine phosphatase SHP-1 protein and of mRNA (Aggarwal et al. 2008;Hsu et al. 2004).

Cytotoxicity

IC50 (μg/mL): 6.7 (518A2), 5.3 (A2780), 7(A549), 6.4 (FaDu), 4.8 (HT29), 5.8(MCF-7), 8.5 (NIH3T3) (Wiemann et al.2016)
IC50 (μg/mL): 12.38 (MGC-803),17.12(HCT-116), 13.39 (T24), 13.81(HepG2), 16.36 (A549), >45.7 (HL-7702)(Hua et al. 2015).

3β-Hydroxyurs-12-en-28-sure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3β-Hydroxyurs-12-en-28-sure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 515)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5892 58
Aktin Chemicals, Inc.
028-85159085
86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
Pharmyao, All for life--- A Specific Trading Platform For Reference Standard Material
13560473592 020-81716320
020-81716319 sales@pharmyao.com CHINA 173 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

77-52-1(3β-Hydroxyurs-12-en-28-sure)Verwandte Suche:


  • 3BETA-HYDROXY-12-URSEN-28-IC ACID
  • 3BETA-HYDROXY-12-URSEN-28-OIC ACID
  • 3B-HYDROXYURS-12-EN-28-OIC ACID
  • Ursolic acid 3beta-Hydroxyurs-12-en-28-oic acid
  • (1S,2R,4aS,6aS,6bR,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
  • Ursoliic acid
  • (3beta)-urs-12-en-28-oicaci
  • 3-hydroxy-,(3.beta.)-Urs-12-en-28-oicacid
  • Ursolic acid powder
  • URSOLIC ACID hplc
  • Urs-12-en-28-oic acid, 3-hydroxy-, (3)-
  • URSOLIC ACID (SAGE EXTRACT)
  • URSOLIC ACID (LIGUSTRUM LUCIDUM AIT)
  • Ursolic
  • Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)-
  • (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
  • URSOLIC ACID(P)
  • URSOLIC ACID(RG)
  • URSOLIC ACID MINIMUM 90%
  • URSOLIC ACID, 90+%
  • URSONIC ACID, 98+% NATURAL STANDARD
  • URSOLIC ACID, 4%
  • URSOLIC ACID, 99+% HPLC
  • UROPORPHYRIN I ETHYL ESTER FROM BOVINE PROPHYRIC URINE
  • URSOLIC ACID, 98+%
  • LoquatLeafExtract-UrsolicAcid25-98%
  • MALOL
  • 3β-Hydroxy-12-ursen-28-ic acid
  • PRUNOL
  • SAGE EXTRACT
  • MICROMEROL
  • URSOLIC ACID
  • URSON
  • 3beta-hydroxyurs-12-en-28-oic acid
  • (1S,2R,4AS,6AS,6BR,8AR,10S,12AR,12BR,14BS)-10-HYDROXY-1,2,6A,6B,9,9,12A-HEPTAMETHYL-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-4A-CARBOXYLIC ACID
  • (3beta)-3-Hydroxy-urs-12-en-28-oic acid
  • URSOLIC ACID,95%
  • 3β-Hydroxyurs-12-en-28-oic acid
  • NSC-4060
  • beta-Ursolic Acid
  • Ursolic acid,3β-Hydroxy-12-ursen-28-ic acid
  • Bungeolic Acid
  • Ursolic acid (Malol)
  • ForMosolic acid
  • Forucosolic acid
  • Masterin
  • Merotaine
  • Neoage UR
  • NSC 167406
  • UrsolisoMe
  • 3-Hydroxy-12-ursen-28-oicacid
  • URSOLIC ACID WITH HPLC
  • Ursolic Acid SynonyMs: 3beta-Hydroxyurs-12-en-28-oic acid
  • UrsoL
  • URSOLIC ACID (PRUNOL)
  • Uosolic Acid
  • Ursolic Acid 77-52-1
  • factory price Ursolic acid 77-52-1
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