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Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid Produkt Beschreibung

Lincomycin hydrochloride Struktur
859-18-7
CAS-Nr.
859-18-7
Bezeichnung:
Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid
Englisch Name:
Lincomycin hydrochloride
Synonyma:
Lizpion;U-10149A;Lincogap;Lincocin;Lincorex;Lintamycin;Pelancocin;Luniamycin;Lyncomycin,HCl;Lincoymcin Hcl
CBNumber:
CB8141837
Summenformel:
C18H35ClN2O6S
Molgewicht:
443
MOL-Datei:
859-18-7.mol

Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid Eigenschaften

Schmelzpunkt:
156-158C
storage temp. 
2-8°C
Löslichkeit
H2O: 50 mg/mL, clear, colorless
Aggregatzustand
solid
Farbe
white to white with yellow cast
Wasserlöslichkeit
Soluble in water.
BRN 
4171650
InChIKey
POUMFISTNHIPTI-BOMBIWCESA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi,Xn
R-Sätze: 36/37/38-20/21/22
S-Sätze: 26-36
WGK Germany  2
RTECS-Nr. RH6315000
10
HS Code  29419000
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Crystalline

Verwenden

An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.

Verwenden

Antibacterial;Ribosomal protein synthesis inhibitor

Verwenden

Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

Trademarks

Lincocin (Pharmacia & Upjohn).

Clinical Use

Lincomycin is used for the treatment of infections causedby Gram-positive organisms, notably staphylococci, β-hemolyticstreptococci, and pneumococci. It is absorbed moderatelywell orally and distributed widely in the tissues.Effective concentrations are achieved in bone for the treatmentof staphylococcal osteomyelitis but not in the cerebrospinalfluid for the treatment of meningitis. At one time,lincomycin was considered a nontoxic compound, with alow incidence of allergy (rash) and occasional GI complaints(nausea, vomiting, and diarrhea) as the only adverseeffects. Recent reports of severe diarrhea and the developmentof pseudomembranous colitis in patients treated withlincomycin (or clindamycin), however, have necessitatedreappraisal of the role of these antibiotics in therapy. In anyevent, clindamycin is superior to lincomycin for thetreatment of most infections for which these antibiotics areindicated.
Lincomycin hydrochloride occurs as the monohydrate, awhite, crystalline solid that is stable in the dry state. It isreadily soluble in water and alcohol, and its aqueous solutionsare stable at room temperature. It is degraded slowlyin acid solutions but is absorbed well from the GI tract.Lincomycin diffuses well into peritoneal and pleural fluidsand into bone. It is excreted in the urine and the bile. It isavailable in capsule form for oral administration and inampules and vials for parenteral administration.

Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 260)Lieferanten
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Anhui Royal Chemical Co., Ltd.
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859-18-7(Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid)Verwandte Suche:


  • LINOCOMYCIN HYDROCHLORIDE
  • (2S,E)-Methyl-6,8-didezoxy-6(1-methyl-4-propylpirrolidine-yl-carbonylamino)-1-thio-D-eritro-a-D-halaktooktopiranoziide, hydrochloride monohydrate
  • Lyncomycin,HCl
  • Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride
  • Lincocin hydrocheoride
  • Lintamycin
  • Lizpion
  • Luniamycin
  • Pelancocin
  • Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
  • (2S,4R)-N-{(1S)-2-hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-2-pyranyl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide Hydrochloride
  • Lincomycin hydrochloride,Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
  • Lincomycin hydrochloride 90%
  • (2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-Methyl-4-propyl-2-pyrrolidinyl)carbonyl] aMino]-1-thio-D3-threo-α-D-galactooctopyranoside Hydrochloride
  • LincoMycin hydrochloride (U-10149A)
  • Linocin, NSC 70731, U 10149a
  • methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside,hydrochloride (1:1)
  • Lincoymcin Hcl
  • Lincomycin hydrochloride (Lincocin)
  • Lineomycin Hydrochloride
  • Lincomycin (U-10149A)
  • LINCOMYCIN HYDROCHLORIDE >= 95.0% (T
  • D-erythro-a-D-galacto-Octopyranoside, methyl6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,hydrochloride
  • Lincomycin hydrochloride Solution, 100ppm
  • Lincomycin hydrochloride Solution, 1000ppm
  • Lincomycin Hydrochloride CAS 859-18-7
  • METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
  • LINCOMYCIN HCL
  • LINCOMYCIN HYDROCHLORIDE
  • LINCOCIN HYDROCHLORIDE
  • ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
  • U-10149A
  • N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE
  • lincomycin standard solution
  • LINCOMYCIN HYDROCHLORIDE CELL CULTURE*TE STED
  • D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, monohydrochloride
  • lincomycin solution
  • D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-
  • D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride (9CI)
  • D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-a- (8CI)
  • Lincogap
  • LINCOMYCINHYDROCHLORIDEANHYDROUS
  • LINCOMYCIN CHLOROHYDRATE
  • Lincocin
  • Lincomycin hydrochloride BP98
  • Lincomycin hydrochloride monohydrate
  • Lincorex
  • Methyl (2S-trans)-6,8-dideoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride
  • 859-18-7
  • C18H34N2O6SxHCl
  • C18H34N2O6SClH
  • C18H34N2O6SHCl
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