3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)-
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- CAS-Nr.
- 22254-24-6
- Bezeichnung:
- 3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)-
- Englisch Name:
- Ipratropium bromide
- Synonyma:
- Ipratropium;Ipratropium Bromide anhydrous;atrovent;IPRATROPIUM BROMIDE EP;[(1r,5s)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide;atem;pate;PATE1;itrop;YB-API
- CBNumber:
- CB9715938
- Summenformel:
- C20H30BrNO3
- Molgewicht:
- 412.37
- MOL-Datei:
- 22254-24-6.mol
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3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Eigenschaften
- Schmelzpunkt:
- 230-232°C
- RTECS-Nr.
- YM3700000
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- H2O: 10 mg/mL
- Aggregatzustand
- powder
- Farbe
- white
- Wasserlöslichkeit
- Freely soluble
- Stabilität:
- Stable. Incompatible with strong oxidizing agents.
- CAS Datenbank
- 22254-24-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
20/22-36 |
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| S-Sätze: |
26 |
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| WGK Germany |
3 |
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| Toxizität |
LD50 in male, female mice (mg/kg): 1001, 1083 orally; 12.29, 14.97 i.v.; 300, 340 s.c.; LD50 in male, female rats (mg/kg): 1663, 1779 orally; 15.89, 15.70 i.v. (Sarafana) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitsschädlich bei Einatmen. |
Akute Toxizität inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White Powder
Verwenden
Ipratropium Bromide is a nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
Definition
ChEBI: The anhydrous form of the bromide salt of ipratropium. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstru
tive pulmonary disease and acute asthma.
Allgemeine Beschreibung
Ipratropium bromide, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide (Atrovent), is a quaternaryammonium derivative of atropine. It is freely soluble inwater and ethanol but insoluble in chloroform and ether. Thesalt is stable in neutral and acidic solutions but rapidly hydrolyzedin alkaline solutions.
Biologische Aktivität
Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.
Clinical Use
Ipratropium bromide is used in inhalation therapy toproduce dilation of bronchial smooth muscle for acute asthmaticattacks. The drug produces bronchodilation by competitiveinhibition of cholinergic receptors bound to smooth muscle of the bronchioles. Ipratropium may also act on thesurface of mast cells to inhibit ACh-enhanced release ofchemical mediators. The drug has a slow onset of action,within 5 to 15 minutes after being administered by inhalation,and should not be used alone for acute asthmatic attacks.The peak therapeutic effect from one dose is observedbetween 1 and 2 hours. The effects of the drug last for about6 hours. It has a half-life of 3.5 hours.
3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 256)Lieferanten
22254-24-6(3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)-)Verwandte Suche:
- N-Isopropylatropinium bromide
- Sch 100
- IPTRATROPIUM BROMIDE
- Ipratropium bromide
- (endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octanebromide
- Ipratropium bromide monohydrate,Atropine isopropyl bromide
- (3-endo,8-syn)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane, bromide (1:1)
- ANTI-PATE1 (C-TERM) antibody produced in rabbit
- PATE1
- Prostate and testis expressed protein 1
- (1s,3s,5r)-3-tropyloxy-8-isopropyltropaniumbromide
- (8r)-3-alpha-hydroxy-8-isopropyl-1-alpha-h,5-alpha-h-tropiumbromide-(+-)-tro
- 1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-isopropyl-,bromide,(+-)-trop
- 3-alpha-hydroxy-8-isopropyl-1-alpha-h,5-alpha-h-tropaniumbromide(+-)-tropat
- 8-isopropylnoratropinemethobromide
- atem
- ipratropiumbromid
- itrop
- n-isopropylnoratropiniumbromomethylate
- pate
- sch1000
- IPRATROPIUM BROMIDE HYDRATE
- (ENDO,SYN)-(+/-)-3-(3-HYDROXY-1-OXO-2-PHENYLPROPOXY)-8-METHYL-8-(1-METHYLETHYL)-8-AZONIABICYCLO[3.2.1]OCTANE BROMIDE
- ATROPINE ISOPROPYLBROMIDE
- Atropine Isopropyl Bromid
- IPRATROPIUMBROMIDE,BP,EP
- 1αH,5αH-Tropanium, 3α-hydroxy-8-isopropyl-, bromide, (+-)-tropate (8CI)
- 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (3-endo,8-syn)-
- 3-(3-HYDROXY-1-OXO-2-PHENYLPROPOXY)-8-METHYL-8-(1-METHYLETHYL)-8-AZONIABICYCLO[3.2.1]-OCTANE BROMIDE
- (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropyl)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane Bromode Monohydrate
- 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, (endo,syn)-, bromide
- 8-Isopropylatropinium bromide
- 3-alpha-Hydroxy-8-isopropyl-1-alpha-H,5-alpha-H-tropanium bromide (±)-tropate
- 2-Methyl-2-[(piperidinomethyl)thio]propionic acid
- 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)-
- 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)-(+-)-
- 8-Isopropylatropinium bromide (6CI, 7CI)
- Atrovent forte
- Ipratropium D3
- 3-hydroxy-2-phenylpropanoic acid [(1S,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester bromide hydrate
- Ipratropium bromide USP/EP/BP
- Ipratropium bromide salt
- Ipratropium Bromide (Sch 1000)
- Ipratropium BromideQ: What is
Ipratropium Bromide Q: What is the CAS Number of
Ipratropium Bromide Q: What is the storage condition of
Ipratropium Bromide Q: What are the applications of
Ipratropium Bromide
- Ipratropium Bromide anhydrous
- atrovent
- Ipratropium
- IPRATROPIUM BROMIDE EP
- [(1r,5s)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide
- 2H6]-Ipratropium bromide salt
- Atrovent Hfa
- YB-API
- 22254-24-6
- 2254-24-6
- 47526-32-7
- C20H30NO3BrH2O
- C20H30NO3Br
- C20H30BO3Rn
