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Progestin

Progestin Structure
Progestin structure
CAS No.
57-83-0
Chemical Name:
Progestin
Synonyms
Lutein;Progesteron;PROCYANIDINS;Progestrone;Lutin;progestin;Pregn-4-ene-3,20-dione;Luteine;Prog;Progestone
CBNumber:
CB00128200
Molecular Formula:
C21H30O2
Molecular Weight:
314.46
MDL Number:
MFCD00003658
MOL File:
57-83-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-29 11:56:07
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Progestin Properties

Melting point 128-132 °C (lit.)
Boiling point 394.13°C (rough estimate)
alpha 186 º (c=1, ethanol)
Density d23 1.166; d20 1.171
refractive index 182 ° (C=2, Dioxane)
Flash point 2℃
storage temp. room temp
solubility H2O: 25 mg/mL, may be clear to slightly hazy
form powder
color Yellow to yellow-brown
biological source synthetic (organic)
Water Solubility <0.1 g/100 mL at 19 ºC
Merck 7773
BRN 1915950
Henry's Law Constant 1.5×102 mol/(m3Pa) at 25℃, HSDB (2015)
BCS Class 4
Stability Stable. Incompatible with strong oxidizing agents.
Major Application pharmaceutical (small molecule)
Cosmetics Ingredients Functions SKIN CONDITIONING
InChI 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChIKey RJKFOVLPORLFTN-LEKSSAKUSA-N
SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
LogP 3.870
CAS DataBase Reference 57-83-0(CAS DataBase Reference)
FDA 21 CFR 556.540
EWG's Food Scores 4-7
NCI Dictionary of Cancer Terms progesterone; progestin
FDA UNII 4G7DS2Q64Y
NCI Drug Dictionary Lutex
ATC code G03DA04
Proposition 65 List Progesterone
NIST Chemistry Reference Progesterone(57-83-0)
EPA Substance Registry System Progesterone (57-83-0)
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Danger
Hazard statements  H351-H360FD-H362
Precautionary statements  P202-P260-P263-P264-P270-P308+P313
PPE Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  Xn,T,F
Risk Statements  40-45-62-36-20/21/22-11
Safety Statements  36/37-45-53-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  TW0175000
TSCA  TSCA listed
HS Code  29372390
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Carc. 2
Lact.
Repr. 1A
Hazardous Substances Data 57-83-0(Hazardous Substances Data)
Toxicity LD50 intraperitoneal in rat: 327mg/kg
REACH Registrations Inactive
NFPA 704
1
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Progestin price More Price(103)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001666 Progesterone for peak identification European Pharmacopoeia (EP) Reference Standard 57-83-0 5 mg $254 2026-04-30 Buy
Sigma-Aldrich Y0001665 Progesterone for system suitability European Pharmacopoeia (EP) Reference Standard 57-83-0 5 mg $254 2026-04-30 Buy
Sigma-Aldrich P3300000 Progesterone European Pharmacopoeia (EP) Reference Standard 57-83-0 120 mg $254 2026-04-30 Buy
Sigma-Aldrich P-069 Progesterone solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 57-83-0 1mL $152 2026-04-30 Buy
Sigma-Aldrich BP449 Progesterone British Pharmacopoeia (BP) Reference Standard 57-83-0 50MG $256 2026-04-30 Buy
Product number Packaging Price Buy
Y0001666 5 mg $254 Buy
Y0001665 5 mg $254 Buy
P3300000 120 mg $254 Buy
P-069 1mL $152 Buy
BP449 50MG $256 Buy

Progestin Chemical Properties, Uses, Production

Description

Progestin is the synthetic (human-made) form of progesterone. Progesterone is a hormone that occurs naturally in your body. Some people need treatment with progestin to treat symptoms or conditions.

Physical properties

Progestin is a white powder, melting point 121°C. Stable in air. Insoluble in water.

Uses

Progestin is a synthetic (human-made) form of progesterone that helps treat certain conditions. It is can used to treatment for issues with menstruation, symptoms of menopause, and many others.

Health Hazard

Acute/chronic hazards: Progesterone may be absorbed through the skin.

Side effects

Common side effects of oral Progesterone include: chest pain, chills, cold or flu-like symptoms; cough or hoarseness; fever, and problems with urination. Rare side effects include: clear or bloody discharge; dimpling of the breast skin, lumps in the breast or armpit; persistent crusting or flaking; redness or swelling of the breast; and sores on the breast skin that do not heal. Other side effects that may occur are: abdominal or stomach pain; constipation, difficulty breathing, dizziness, fast, strong, or irregular heartbeat or pulse; headache, measles, indigestion, itching, joint pain, stiffness, or swelling; rash.

Synthesis

Progestin, pregn-4-en-3,20-dione (28.3.1), is made by oxidizing pregnenolon with aluminum isopropylate in the presence of cyclohexanone as a proton acceptor (Oppenauer oxidation). Progestin itself is made by subsequent oxidation and further cleavage of the side chain of stigmasterin, a sterin of plant origin that is isolated from soybeans.

Physiological effects

Progestin is believed to act by inducing decidualization and atrophy of the endometrial tissue within endometriotic implants. Progestin also interfere with follicular growth probably via a central mechanism on the pituitary–hypothalamic unit, but a local ovarian effect is also possible. This will result in decreased estrogen levels.

Toxicity

Low toxicity

Progestin synthesis

60966-36-1
57-83-0
Synthesis of Progestin from 21-hydroxy-20-methylpregn-4-en-3-one

Progestin Preparation Products And Raw materials

Raw materials

Pregnenolone dilute sulphuric acid Aluminium isopropoxide 16-Dehydropregnenolone acetate Cyclohexanone

Preparation Products

17-Hydroxy-16-methylpregna-5,9(11)-diene-3,20-dione 3,20-diethyleneketal Deoxycorticosterone acetate 16,17-Epoxypregna-5,9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal) 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate 16-Dehydroprogesterone
17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate 11alpha-Hydroxyprogesterone Dexamethasone-17-acetate Pregnanedione 9,11β-Epoxy-17-hydroxy-16β-methyl-3,20-dioxo-9β-pregna-1,4-diene-21-yl Acetate
Methyl 4-aza-5alpha-androsta-3-one-17beta-carboxylate Pregna-4,14-diene-3,20-dione 5α-Pregnane-3,20-dione 4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid

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Progestin Suppliers

Global Suppliers ( 1105)
Supplier Tel Email Country ProdList Advantage
Shaanxi billion Kang Long biological technology co., LTD 17791478691 yklbiotech@163.com China 298 58
Hubei widely chemical technology Co., Ltd. 027-83989310 18627915365 2658488909@qq.com China 1139 58
CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. 15310426561 lf19823605252@163.com China 145 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 4000862158 18117107507 vip@med-life.cn China 4999 58
Hangzhou Kehui Pharmaceutical Co.,Ltd 0571-87359773 18094707759 sales10@hzkehuipharma.com China 68 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Supplier Advantage
Shaanxi billion Kang Long biological technology co., LTD 58
Hubei widely chemical technology Co., Ltd. 58
CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
Hangzhou Kehui Pharmaceutical Co.,Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65

Related articles

Related Questions

Ask a question
Q:What is the mechanism of action of progesterone? What are its side effects?Zora - Apr 3,2026
A:Progesterone has crucial functions in preparing the uterus for a pregnancy as well as in maintaining pregnancy. More specifically, progesterone prepares the endometrium for implantation. Moreover, progesterone functions as vasodilator (Rylance et al., 1985, Ngene and Moodley, 2019), thus contributing to reducing blood pressure during pregnancy. The side effects of progesterone injection are mainly related to local irritation caused by injection. Suppositories are messy and sometimes give vaginal irritation, itching, burning, or yeast infection. The oral progesterone is well tolerated with side-effects in some women of dizziness or sleepiness.

Progesterone Spectrum

Progesterone(57-83-0)MSProgesterone(57-83-0)1HNMRProgesterone(57-83-0)13CNMRProgesterone(57-83-0)IR1Progesterone(57-83-0)IR2Progesterone(57-83-0)Raman

57-83-0 (Progestin) Related Search:

Pregnenolone Gestonorone Gestrinone Gestodene Pregnenolone acetate
(3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one 16-Dehydropregnenolone acetate Eltanolone Progesterone-d9 Progesterone-[2,3,4-13C3]
Progesterone-[2,3,4,20,21-13C5] Z-Guggulsterone Progesterone-d9 HLH Lutropinalfa
Medroxyprogesterone Acetate Megestrol acetate 17α-Hydroxyprogesterone Progesteron Progestin

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delta(Sup4)-pregnene-3,20-dione delta-Pregnene-3,20-dione Gesterol Gesterol 100 Gesterol 50 gesterol100 Gestiron Gestormone Gestron Luteum Lutex Lutidon Lutociclina Lutocuclin M Lutocyclin m lutocyclinm Lutocylin Lutoform Lutogyl Lutromone Membrettes Methylpregnone Nalutron NSC-9704 Percutacrine Percutacrine luteinique percutacrineluteinique Piaponon Pregn-4-en-3,20-dione Pregn-4-ene-3,20-dione, 17alpha-hydroxy-6alpha-methyl- Pregnene-3,20-dione Pregnenedione Progekan pregesterone Progesterone　Injection PROGESTERONE USP MICRONIZED PROGESTERONE USP PROGESTERONE, CELL CULTURE TESTED Progesterone, Topical, Powder, Micronized grogesterone HYDROXY PROGESTERRONE CAPTORATE BP98 Progeseterone (8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Progesterone,98% PROGESTERONEANALYTICAL GRADE Progesterone,4-Pregnene-3,20-dione Progesterone (200 mg) Progesterone (200 mg)I0D3730.998mg/mg(ai) Progesterone COS (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one PROGESTERONE(AS) Progesterone for system suitability Progesterone for peak identification Lutein and zeaxanthin in corn oil Progesterone: 2-hydroxypropyl-β-cyclodextrin complex Progesterone: HBC complex Progesterone solution PROGESTERONE-WATER SOLUBLE