Noradrenalin
- CAS No.
- 51-41-2
- Chemical Name:
- Noradrenalin
- Synonyms
- NORADRENALINE;L-NORADRENALINE;NORADRENALIN;levophed;adrenor;aktamin;norartrinal;levoarterenol;(?)-Norepinephrine;arterenolfreebase(noradrenaline)
- CBNumber:
- CB00131073
- Molecular Formula:
- C8H11NO3
- Molecular Weight:
- 169.18
- MDL Number:
- MFCD00025592
- MOL File:
- 51-41-2.mol
| Melting point | 220-230°C |
|---|---|
| alpha | D25 -37.3° (c = 5 in water with 1 equiv HCl) |
| Boiling point | 298.46°C (rough estimate) |
| Density | 1.2435 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly) |
| form | crystalline |
| pka | 8.64(at 25℃) |
| color | off-white to tan |
| Water Solubility | Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether. |
| Sensitive | Air & Light Sensitive |
| Merck | 14,6695 |
| BRN | 4231961 |
| Stability | Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20℃. |
| CAS DataBase Reference | 51-41-2(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | noradrenaline; norepinephrine |
| FDA UNII | X4W3ENH1CV |
| NCI Drug Dictionary | norepinephrine |
| ATC code | C01CA03 |
| EPA Substance Registry System | Norepinephrine (51-41-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T+,C,F | |||||||||
| Risk Statements | 26/27/28-34-11-28 | |||||||||
| Safety Statements | 28-36/37-45-36/37/39-26-16-20 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DN5950000 | |||||||||
| F | 8-10-23 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29225090 | |||||||||
| Toxicity | dni-hmn:oth 5800 nmol/L CNREA8 40,1414,80 | |||||||||
| NFPA 704 |
|
Noradrenalin price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A7257 | (?)-Norepinephrine ≥98%, crystalline | 51-41-2 | 1g | $417 | 2024-03-01 | Buy |
| Sigma-Aldrich | A7257 | (?)-Norepinephrine ≥98%, crystalline | 51-41-2 | 5g | $1500 | 2024-03-01 | Buy |
| Alfa Aesar | L08087 | L-Noradrenaline, 98% | 51-41-2 | 1g | $359 | 2024-03-01 | Buy |
| Sigma-Aldrich | A7257 | (?)-Norepinephrine ≥98%, crystalline | 51-41-2 | 500mg | $228 | 2024-03-01 | Buy |
| TRC | N661038 | L-Noradrenaline | 51-41-2 | 1g | $265 | 2021-12-16 | Buy |
Noradrenalin Chemical Properties,Uses,Production
Description
Noradrenaline, a catecholamine, is derived from l-tyrosine, an aromatic amino acid present in the body fluids and taken up by noradrenaline-producing cells.
Biological Functions
Most central noradrenergic neurons are located in the nucleus locus ceruleus of the pons and in neurons of the reticular formation. Fibers from these nuclei innervate a large number of cortical, subcortical, and spinomedullary fields. Many functions have been ascribed to the central noradrenergic neurons, including a role in affective disorders, in learning and memory, and in sleep–wake cycle regulation.The mammalian CNS contains both α- and β-adrenoceptors.
Pharmaceutical Applications
Norepinephrine is both a neurotransmitter and a hormone.As a medication, norepinephrine is used to increase and maintain blood pressure in limited, short-term serious health situations.
Pharmacology
The general function of Noradrenalin is to mobilize the brain and body for action. Noradrenalin release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. In the brain, noradrenalin increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention; it also increases restlessness and anxiety. In the rest of the body, noradrenalin increases heart rate and blood pressure, triggers the release of glucose from energy stores, increases blood flow to skeletal muscle, reduces blood flow to the gastrointestinal system, and inhibits voiding of the bladder and gastrointestinal motility.
Clinical Use
Noradrenalin is used to increase and maintain blood pressure in limited, short-term serious health situations.
Side effects
Side effects of norepinephrine as an injection that require medical attention include:
Allergic reactions like skin rash, itching or hives, swelling of your face, lips or tongue.
Difficulty breathing, wheezing.
Irregular heartbeats, palpitations or chest pain.
Pain, redness or irritation at site where injected.
Synthesis
Noradrenalin, L-1-(3,4-dihydroxyphenyl)-2-aminoethanol (11.1.4), is synthesized by two methods starting from 3,4-dihydroxybenzaldehyde. According to the first method, the indicated aldehyde is transformed into the cyanohydrin (11.1.3) by reaction with hydrogen cyanide, which is then reduced into norepinephrine (11.1.5).
Noradrenalin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
Related articles
- Biological functions of Norepinephrine
- Noradrenaline and adrenaline are catecholamines, which play important roles as neurotransmitters and hormones.
- Jun 23，2022
View Lastest Price from Noradrenalin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-21 | Sodium tetraborate pentahydrate
12179-04-3
|
1kg | 99% | 100tons | Anhui Ruihan Technology Co., Ltd |
-
- Sodium tetraborate pentahydrate
12179-04-3
- 99%
- Anhui Ruihan Technology Co., Ltd
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