ChemicalBook >> CAS DataBase List >>Landiolol

Landiolol

Landiolol structure

CAS No.: 133242-30-5

Chemical Name:: Landiolol

Synonyms: [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate;ONO1101;ONO 1101;ONO-1101;Landiolol;Landiolol D8;Landiolol USP/EP/BP;Landiolol HCL EP USP;((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate;((–)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-{4-[(S)-2-hydroxy-3-(2-morpholino-carbonylamino)ethylamino] propoxy}phenylpropionate)

CBNumber:: CB01011742

Molecular Formula:: C25H39N3O8

Molecular Weight:: 509.59

MDL Number:: MFCD00911043

MOL File:: 133242-30-5.mol

Modify Date:2022-12-21 16:56:50

Request For Quotation

Landiolol Properties

FDA UNII	62NWQ924LH
ATC code	C07AB14

Landiolol price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0007877	LANDIOLOL 95.00%	133242-30-5	5MG	$496.96	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0007877	5MG	$496.96	Buy

Landiolol Chemical Properties,Uses,Production

Description

Landiolol was launched as iv infusion for the treatment of tachyarrhythmia during surgery. This structurally related derivative of esmolol can be synthesized in 3 linear steps from 3-(4-hydroxyphenyl)propionic acid by successive esterification followed by alkylation of the phenol function with (2S)-glycidyltosylate and opening of the resulting epoxide by the appropriate amine. Landiolol is an ultra short acting PI-adrenergic blocker more cardioselective (βI/β2 = 255) than esmolol (βi/β2 = 32). It showed 6-8 times greater efficiency compared to esmolol in reducing isoproterenol-induced increase in heart rate and ventricular contraction in anesthetized dogs. In clinical trials, landiolol was effective against a variety of arrhythmias with efficacy seen in patients with atrial fibrillation, proxysmal supraventricular tachycardia, ventricular tachycardia and premature complexes. Landiolol produced a doserelated pharmacokinetic behavior, has a rapid onset of action (10 min.) and is rapidly hydrolyzed to inactive acidic metabolites by esterases after iv administration. This results in an ultra-short half-life (approx. 3 min.) and p-blocade, allowing rapid termination of the drug effect by termination of infusion if side effects occur. Hypertension was the most frequent adverse event and resolved in less than 30 min. after drug withdrawal.

Originator

Ono Pharmaceutical (Japan)

brand name

Onoact

Landiolol Preparation Products And Raw materials

Raw materials

Preparation Products

Landiolol Suppliers

Global( 43)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.	+86-28-87843998-6060 +8618980796919	alanchen@aupone.com	China	26	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21975	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47427	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29828	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-87569262 +8615319740599	1007@dideu.com	China	3981	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	Service@dideu.com	China	29991	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15525	58
Sinoway Industrial co., ltd.	+8613806035118	xie@china-sinoway.com	China	1047	58
Wuhan Golt Biotech Co., Ltd.	+8615389281203	maria@goltbiotech.com	China	980	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58

Supplier	Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Sinoway Industrial co., ltd.	58
Wuhan Golt Biotech Co., Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Landiolol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-13	Landiolol USP/EP/BP 133242-30-5	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2020-05-12	Landiolol 133242-30-5	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
2020-01-13	Landiolol 133242-30-5	US $0.01 / KG	1KG	98%; 99%	500g；1kg; 25kg	Career Henan Chemical Co

Landiolol USP/EP/BP
133242-30-5
US $1.10 / g
99.9%
Dideu Industries Group Limited

Landiolol
133242-30-5
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Landiolol
133242-30-5
US $0.01 / KG
98%; 99%
Career Henan Chemical Co

133242-30-5(Landiolol)Related Search:

Tropisetron Dimethyl disulfide ETHANE Dimethyl ether Dimethyl sulfate

3-(4-PROPOXYPHENYL)PROPIONIC ACID Landiolol Moroxydine Tridemorph Dimethomorph

LandiololHCL (2S)-glycidyl-3-nitrobenzenesulfonate (Landiolol) 4-Morpholinecarboxamide, N-(2-aminoethyl)-, ethanedioate (Landiolol) BENZENEPROPANOIC ACID,4-HYDROXY-,(2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)METHYL ESTER (4S)-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4- hydroxybenzene) propanoic acid,methyl ester (Landiolol)

2,3-ISOPROPYLIDENEGLYCEROL-1-PROPIONATE Dacthal Moroxydine hydrochloride

1of4

Landiolol ONO-1101 ONO1101 ONO 1101 Landiolol D8 Landiolol HCL EP USP Landiolol USP/EP/BP ((–)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-{4-[(S)-2-hydroxy-3-(2-morpholino-carbonylamino)ethylamino] propoxy}phenylpropionate) (-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-hydroxy-3-(2-morpholino-carbonylamino)ethylamino]propoxy]phenylpropionate monohydrochloride Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester ((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate 133242-30-5 C25H39N3O8 C25H39N3O8ClH