Barnidipine
- CAS No.
- 104713-75-9
- Chemical Name:
- Barnidipine
- Synonyms
- BARNIDIPINE;Barnidipine-d5;Barnidipine(b);YM-09730-5(Free base);Barnidipine USP/EP/BP;Barnidipine,Inhibitor,Ca2+ channels,Calcium Channel,inhibit,Ca channels;(S)-3-((S)-1-Benzylpyrrolidin-3-yl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridin;(S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3;(+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;(S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- CBNumber:
- CB02130255
- Molecular Formula:
- C27H29N3O6
- Molecular Weight:
- 491.54
- MDL Number:
- MFCD00871351
- MOL File:
- 104713-75-9.mol
- MSDS File:
- SDS
| Melting point | 137-139° |
|---|---|
| alpha | D20 +64.8° (c = 1 in methanol) |
| Boiling point | 614.5±55.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO |
| pka | 7.62±0.40(Predicted) |
| FDA UNII | 2VBY96ASWJ |
| ATC code | C08CA12 |
Barnidipine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB37568 | Barnidipine | 104713-75-9 | 2mg | $40 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB37568 | Barnidipine | 104713-75-9 | 5mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB37568 | Barnidipine | 104713-75-9 | 10mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB37568 | Barnidipine | 104713-75-9 | 25mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB37568 | Barnidipine | 104713-75-9 | 50mg | $200 | 2021-12-16 | Buy |
Barnidipine Chemical Properties,Uses,Production
Description
Barnidipine is a long-acting novel calcium antagonist that belongs to the dihydropyridine (DHP) group of calcium channel blockers. It contains two chiral centres thus can have four possible enantiomers. The active component is composed of a single optical isomer (3'S, 4S configuration), which is the most potent and longest-acting of the four enantiomers. Barnidipine has shown to be an effective antihypertensive agent in the management of hypertension in elderly patients and its efficacy is not negatively affected by age.
Originator
Barnidipine,Yamanouchi
Uses
Barnidipine is used in the treatment of hypertension, barnidipine displays high affinity for the calcium channels of the smooth muscle cells in the vascular wall and selectivity against cardiovascular L-type calcium channels.
Definition
ChEBI: Barnidipine is a dihydropyridine.
Manufacturing Process
In 5 ml of isopropyl alcohol were dissolved 1.5 g (0.01 mole) of 3- nitrobenzaldehyde, 2.6 g (0.01 mole) of 1-benzyl-3-acetoacetyloxypyrrolidine, and 1.3 g (0.01 mole) of β-aminocrotonic acid methyl ester and then the solution was refluxed for 8 hours. The solvent was distilled off under reduced pressure, the residue obtained was dissolved in a small amount of chloroform, and the solution was applied to silica gel column chromatography (column diameter 1.5 cm, height 20 cm, and about 200 ml of chloroform was used as the eluent). The eluates were collected and concentrated to give 3.4 g of oily 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3- (1-benzylpyrrolidin-3-yl)ester-5-methyl ester: [α]D 20=+64.8° (c = 1 in methanol).
Therapeutic Function
Coronary vasodilator
Side effects
The side effects of barnidipine are typically mild to moderate and typically occur at the beginning of treatment. Common side effects include nausea, palpitations, flushed face, hot flashes, swelling, headache, heavy sensation in the head, dizziness, and a feeling of unsteadiness. Other reported side effects include redness, rash, itching, and sensitivity to sunlight.
Precautions
The medicine may cause dizziness, etc. due to decreased blood pressure. Pay close attention when you work at heights, drive a car or operate dangerous machinery.
Since intake of grapefruit juice may enhance the effect of the medicine, refrain from drinking it.
References
[1] LIAUCHIAU-SUONG. Barnidipine: a new calcium channel blocker for hypertension treatment.[J]. Expert Review of Cardiovascular Therapy, 2005. DOI:10.1586/14779072.3.2.207.
[2] CHENGZHI-GANG. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.[J]. Molecules, 2014. DOI:10.3390/molecules19011344.
[3] https://www.ltl-pharma.com/common/pdf/product/hypoca/hypoca15_capsule_siori_en.pdf
[4] DEROSAGIUSEPPE. Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus.[J]. BMC Cardiovascular Disorders, 2016. DOI:10.1186/s12872-016-0237-z.
Barnidipine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 13854 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9553 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
View Lastest Price from Barnidipine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-12 | Barnidipine
104713-75-9
|
US $0.00-0.00 / KG | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-17 | (+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
104713-75-9
|
US $1.00 / KG | 1KG | 85.0-99.8% | 200kgs | Career Henan Chemical Co |
-
- Barnidipine
104713-75-9
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- (+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
104713-75-9
- US $1.00 / KG
- 85.0-99.8%
- Career Henan Chemical Co