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Mecamylamine hydrochloride

Mecamylamine hydrochloride
Mecamylamine hydrochloride structure
CAS No.
826-39-1
Chemical Name:
Mecamylamine hydrochloride
Synonyms
inversine;MECAMYLAMINE;Mecamylamine HCl;MecaMycaMine HCl;MECAMYLAMINE USP;mevasinhydrochloride;mekaminhydrochloride;mecaminehydrochloride;inversinehydrochloride;MecamycamineHydrochloride
CBNumber:
CB0215071
Molecular Formula:
C11H22ClN
Formula Weight:
203.75
MOL File:
826-39-1.mol

Mecamylamine hydrochloride Properties

Melting point:
>240°C (dec.)
storage temp. 
Desiccate at RT
solubility 
ethanol: 122 mg/mL
pka
pKa 11.2(H2O,t undefined,I=0.1) (Uncertain)
form 
neat
CAS DataBase Reference
826-39-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  36/37/39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  RB6900000
HazardClass  6.1
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Mecamylamine hydrochloride price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M9020 Mecamylamine hydrochloride 826-39-1 5mg $48.7 2018-11-13 Buy
Sigma-Aldrich 1376006 Mecamylamine hydrochloride United States Pharmacopeia (USP) Reference Standard 826-39-1 200mg $348 2018-11-13 Buy
Alfa Aesar J60257 Mecamylamine hydrochloride 826-39-1 100mg $554 2018-11-13 Buy
Alfa Aesar J60257 Mecamylamine hydrochloride 826-39-1 25mg $155 2018-11-13 Buy
Cayman Chemical 14602 Mecamylamine (hydrochloride) ≥98% 826-39-1 10mg $53 2018-11-13 Buy

Mecamylamine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Antihypertensive;Cholinergic receptor antagonist

Uses

Nicotinic receptor antagonist; orally active ganglionic blocker. Antihypertensive.

Uses

A noncompetitive nicotinic AChR inhibitor.

Uses

Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM). Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.[Cayman Chemical]

General Description

The secondary aminemecamylamine hydrochloride, N,2,3,3-tetramethyl-2-norbornanaminehydrochloride (Inversine), has a powerful ganglionicblocking effect that is almost identical to that ofhexamethonium. It has an advantage over most of the ganglionicblocking agents in being absorbed readily andsmoothly from the GI tract. It is rarely used, however, forthe treatment of moderate-to-severe hypertension becausesevere orthostatic hypotension occurs when the drug blockssympathetic ganglia.

Biological Activity

Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.

Mecamylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Mecamylamine hydrochloride Suppliers

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