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Levomepromazine hydrochloride

CAS No.
1236-99-3
Chemical Name:
Levomepromazine hydrochloride
Synonyms
Einecs 214-978-3;LevomepromazineHCl;7044 Rp hydrochloride;Levomepromazinium chloride;Levopromazine hydrochloride;Levomepromazine hydrochloride;Levomepromazine D6 hydrochloride;Levomepromazine hydrochloride CRS;Levomepromazine hydrochloride(HCl);Levomepromazine hydrochloride [usan:jan]
CBNumber:
CB0888820
Molecular Formula:
C19H24N2OS.ClH
Molecular Weight:
364.93
MDL Number:
MOL File:
1236-99-3.mol
Last updated:2023-05-04 17:34:32

Levomepromazine hydrochloride Properties

storage temp. 2-8°C
FDA UNII 42BB1Y2586

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H317-H411
Precautionary statements  P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Toxicity LD50 oral in mouse: 380mg/kg

Levomepromazine hydrochloride price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L0500000 Levomepromazine hydrochloride European Pharmacopoeia (EP) Reference Standard 1236-99-3 l0500000 $153 2024-03-01 Buy
American Custom Chemicals Corporation INB0000731 LEVOMEPROMAZINE HYDROCHLORIDE 95.00% 1236-99-3 5MG $909.56 2021-12-16 Buy
Product number Packaging Price Buy
L0500000 l0500000 $153 Buy
INB0000731 5MG $909.56 Buy

Levomepromazine hydrochloride Chemical Properties,Uses,Production

Originator

Levoprome ,Lederle,US,1966

Uses

Analgesic (central nervous system depressant).

Definition

ChEBI: Levomepromazine hydrochloride is a member of phenothiazines.

Manufacturing Process

95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.

brand name

Nozinan (Aventis).

Therapeutic Function

Analgesic

Levomepromazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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LevomepromazineHCl 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, monohydrochloride, (bR)- (9CI) 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, monohydrochloride, (R)- 10-(3-Dimethylamino-2-methylpropyl)-2-methoxyphenothiazine hydrochloride Levomepromazine hydrochloride 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, monohydrochloride, (R)- (9ci) 7044 Rp hydrochloride Einecs 214-978-3 Levomepromazine hydrochloride [usan:jan] Levomepromazinium chloride Levopromazine hydrochloride (R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropylamine hydrochloride 3-(2-methoxy-10-phenothiazinyl)-N,N,2-trimethyl-1-propanamine Levomepromazine hydrochloride CRS Levomepromazine D6 hydrochloride TIANFU-CHEM CAS NO.1236-99-3 Levomepromazine hydrochloride Levomepromazine hydrochloride(HCl) 1236-99-3 C19H24N2OSHCl