Levomepromazine hydrochloride
- CAS No.
- 1236-99-3
- Chemical Name:
- Levomepromazine hydrochloride
- Synonyms
- Einecs 214-978-3;LevomepromazineHCl;7044 Rp hydrochloride;Levomepromazinium chloride;Levopromazine hydrochloride;Levomepromazine hydrochloride;Levomepromazine D6 hydrochloride;Levomepromazine hydrochloride CRS;Levomepromazine hydrochloride(HCl);Levomepromazine hydrochloride [usan:jan]
- CBNumber:
- CB0888820
- Molecular Formula:
- C19H24N2OS.ClH
- Molecular Weight:
- 364.93
- MDL Number:
- MOL File:
- 1236-99-3.mol
storage temp. | 2-8°C |
---|---|
FDA UNII | 42BB1Y2586 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS09 |
---|---|
Signal word | Warning |
Hazard statements | H302-H317-H411 |
Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
Toxicity | LD50 oral in mouse: 380mg/kg |
Levomepromazine hydrochloride price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | L0500000 | Levomepromazine hydrochloride European Pharmacopoeia (EP) Reference Standard | 1236-99-3 | l0500000 | $153 | 2024-03-01 | Buy |
American Custom Chemicals Corporation | INB0000731 | LEVOMEPROMAZINE HYDROCHLORIDE 95.00% | 1236-99-3 | 5MG | $909.56 | 2021-12-16 | Buy |
Levomepromazine hydrochloride Chemical Properties,Uses,Production
Originator
Levoprome ,Lederle,US,1966
Uses
Analgesic (central nervous system depressant).
Definition
ChEBI: Levomepromazine hydrochloride is a member of phenothiazines.
Manufacturing Process
95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.
brand name
Nozinan (Aventis).
Therapeutic Function
Analgesic
Levomepromazine hydrochloride Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21700 | 55 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9589 | 58 |
Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18459 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 132020 | 58 |
Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23931 | 58 |
ChemStrong Scientific Co.,Ltd | 0755-66853366 15920483169 | sales@chem-strong.com | China | 17944 | 56 |