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(+)-Pilocarpine hydrochloride

Description Reference
(+)-Pilocarpine hydrochloride
(+)-Pilocarpine hydrochloride
CAS No.
54-71-7
Chemical Name:
(+)-Pilocarpine hydrochloride
Synonyms
pilocar;pilocel;Sanpilo;Salagen;ami-pilo;pilovisc;NSC 5746;(3S,4R)-;Akarpine;amisturap
CBNumber:
CB1236112
Molecular Formula:
C11H17ClN2O2
Formula Weight:
244.72
MOL File:
54-71-7.mol

(+)-Pilocarpine hydrochloride Properties

Melting point:
202-205 °C(lit.)
alpha 
89 º (C=5, H2O)
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
white
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,7424
BRN 
4034491
Stability:
Hygroscopic
CAS DataBase Reference
54-71-7(CAS DataBase Reference)
EPA Substance Registry System
2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl- 1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S,4R)-(54-71-7)

SAFETY

Hazard Codes  T+,T
Risk Statements  26/28-25-23
Safety Statements  25-45
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  TK1450000
3-8-10
HazardClass  6.1
PackingGroup  III
HS Code  29399990

(+)-Pilocarpine hydrochloride price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1538902 Pilocarpine hydrochloride United States Pharmacopeia (USP) Reference Standard 54-71-7 200mg $352.8 2018-11-20 Buy
Sigma-Aldrich P0472 Pilocarpine hydrochloride meets USP testing specifications 54-71-7 10g $368 2018-11-20 Buy
Cayman Chemical 14487 (+)-Pilocarpine (hydrochloride) ≥98% 54-71-7 5g $150 2018-11-13 Buy
Cayman Chemical 14487 (+)-Pilocarpine (hydrochloride) ≥98% 54-71-7 1g $33 2018-11-13 Buy
Sigma-Aldrich PHR1493 Pilocarpine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 54-71-7 500mg $79.3 2018-11-20 Buy

(+)-Pilocarpine hydrochloride Chemical Properties,Uses,Production

Description

It is a bioactive chemical usually used as pharmaceutical agents such as acetylcholine receptor agonist, antiglaucoma agent, moitic, and sialogogue. Specifically, due to its desirable activity as acetylcholine receptor agonist, this chemical has been introduced to regulate muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice.1 Moreover, because of its good antiglaucoma effect, this substance is applied in a timolol plus maximum-tolerated antiglaucoma therapy.2 In addition, this chemical has been demonstrated to show a favourable miotic activity when incorporated into polymer capsules.3 Besides, this compound can be utilized to relieve the xerostomia due to chronic graft-versus-host disease or total-body irradiation after bone-marrow transplantation for hematologic malignancies.4

Reference

  1. Li, B.; Duysen, E. G.; Volpicelli-Daley, L. A.; Levey, A. I.; Lockridge, O., Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacol. Biochem. Behav. 2003, 74, 977-986.
  2. Zimmerman, T. J.; Gillespie, J. E.; Kass, M. A.; Yablonski, M. E.; Becker, B., TIMOLOL PLUS MAXIMUM-TOLERATED ANTI-GLAUCOMA THERAPY. Arch. Ophthalmol. 1979, 97, 278-279.
  3. V Vidmar; S Pepeljnjak; Jalsenjak, I., The in vivo evaluation of poly(lactic acid) microcapsules of pilocarpine hydrochloride. Journal of Microencapsulation 1985, 2, 289-292.
  4. Nagler, R. M.; Nagler, A., Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study. Bone Marrow Transplant. 1999, 23, 1007-1011.

Chemical Properties

Crystalline Solid

Uses

Acetylcholine receptor agonist

Uses

Antiglaucoma agent; miotic; sialogogue.

Uses

(+)-Pilocarpine is a muscarinic M1 and M2 acetylcholine receptor agonist with pKB values of 5 and 3.7, respectively. Systemic administration of (+)-pilocarpine is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses.

brand name

Pilopine (Alcon); Salagen (Millot Laboratories, France).

Biological Activity

Muscarinic agonist.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Experimental teratogenic and reproductive effects. Human systemic effects: cardiac changes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PILOCARPINE.

(+)-Pilocarpine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


(+)-Pilocarpine hydrochloride Suppliers

Global( 114)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2238 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19990 58
Chengdu GLP Biotech Co., Ltd
13350802083
scglp@glp-china.com CHINA 1002 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3624 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69

View Lastest Price from (+)-Pilocarpine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 (+)-Pilocarpine hydrochloride
54-71-7
US $2.00 / kg 1kg 99% 100kg career henan chemical co

(+)-Pilocarpine hydrochloride Spectrum


54-71-7((+)-Pilocarpine hydrochloride)Related Search:


  • ALMOCARPINE HYDROCHLORIDE
  • 3-ETHYL-4-[(1-METHYL-5-IMIDAZOLYL)METHYL]TETRAHYDROFURAN-2-ONE HYDROCHLORIDE
  • (3S,4R)-4,5-DIHYDRO-3-ETHYL-4-(1-METHYL-1H-IMIDAZOL-5-YLMETHYL)-2(3H)-FURANONE HYDROCHLORIDE
  • (3S-CIS)-3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2(3H)-FURANONE HYDROCHLORIDE
  • PILOCARPINE HCL
  • (+)-PILOCARPINE HYDROCHLORIDE
  • PILOCARPINE HYDROCHLORIDE
  • (3s-cis)-ochlorid
  • 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-,monohydrochloride,(3S-cis)-2(3H)-Furanone
  • 3-ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanonmonohydr
  • almocarpine
  • ami-pilo
  • amisturap
  • isopto-carpine
  • mi-piloophthsol
  • pilocar
  • pilocarpine,monohydrochloride
  • pilocarpinemuriate
  • pilocel
  • pilomiotin
  • pilovisc
  • Pilocarpine hydrocholoride
  • PILOCARPINE HCL. USP
  • PILOCARPINE HYDROCHLORIDE USP
  • (+)-Pilocarpinehydrochloride,99%
  • Pilocarpine hydrochlororide
  • 2(3H)-Furanone, 3-ethyldihydro-4-(1-methyl-1H-imidazol-5-yl)methyl-, monohydrochloride, (3S,4R)-
  • PILOCARPINEHYDROCHLORIDE,CRYSTAL,USP
  • 54-71-7
  • Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.
  • Alkaloids (Others)
  • Alkaloids
  • PILOCARPINE HCL(RG)
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S,4R)- (9CI)
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S-cis)-
  • Adsorbocarpine
  • NSC 5746
  • Pilocar SMP
  • Sanpilo
  • Pilocarpine HCL & Nitrate
  • PIEFELTARRAENIN IA(SH)
  • Pilocarpine Hydrochloride (200 mg)
  • Pilocarpin Hydrochloride
  • (3S,4R)-
  • PILOCARPINE HCL(P)
  • Akarpine
  • AlMocarpin
  • Pilopine VS
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, hydrochloride (1:1), (3S,4R)-
  • NSC 5746 HCl
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • C11H16N2O2xHCl
  • Pilocarpal
  • Pilocarpine, monohydrochloride (8CI)
  • Salagen
  • Pilocarpinhydrochlorid
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