Orazamide
- CAS No.
- 2574-78-9
- Chemical Name:
- Orazamide
- Synonyms
- Orazamide;Qrazamide;AICA orotate;aicamindihydrate;aicoratdihydrate;Orazamide orotate;orazamidedihydrate;Orazamide USP/EP/BP;aicaorotatedihydrate;5-Aminoimedazole-4-carboxamideorotate
- CBNumber:
- CB1476435
- Molecular Formula:
- C9H10N6O5
- Molecular Weight:
- 282.21
- MDL Number:
- MFCD00867162
- MOL File:
- 2574-78-9.mol
| Melting point | 284-285 °C (decomp) |
|---|---|
| InChI | InChI=1S/C5H4N2O4.C4H6N4O.2H2O/c8-3-1-2(4(9)10)6-5(11)7-3;5-3-2(4(6)9)7-1-8-3;;/h1H,(H,9,10)(H2,6,7,8,11);1H,5H2,(H2,6,9)(H,7,8);2*1H2 |
| InChIKey | RAZMBRTXTADRMQ-UHFFFAOYSA-N |
| SMILES | C1(C(=O)O)NC(NC(=O)C=1)=O.C1(C(=O)N)NC=NC=1N.O.O |
| CAS DataBase Reference | 2574-78-9(CAS DataBase Reference) |
| FDA UNII | CLY9MRR8FV |
Orazamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | O670608 | Orazamide | 2574-78-9 | 500mg | $60 | 2021-12-16 | Buy |
| TRC | O670608 | Orazamide | 2574-78-9 | 2.5g | $175 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003691 | ORAZAMIDE 95.00% | 2574-78-9 | 5MG | $504.79 | 2021-12-16 | Buy |
| AvaChem | 1613 | Orazamide | 2574-78-9 | 10mg | $189 | 2021-12-16 | Buy |
| AHH | MT-57521 | Orazamide 98% | 2574-78-9 | 0.1g | $330 | 2021-12-16 | Buy |
Orazamide Chemical Properties,Uses,Production
Originator
Aicamine, Labaz , France ,1971
Uses
Orazamide is an AICA orotate. Orazamide can prevent anti-TB drug-induced liver damage by downregulating the protein expression of HMGB 1 and RAGE in liver tissue and inhibiting the secretion of inflammatory factors. Orazamide can be used in research on hepatitis and liver cirrhosis[1].
Manufacturing Process
14.4 grams of 4-amino-5-imidazolecarboxamide (monohydrate) and 17.4 grams of orotic acid (monohydrate) were dissolved with heating in 600 cc of water. The solution is decolorized with Norit, cooled and then filtered off. 28.8 grams of a white crystalline salt (dihydrate) is obtained with MP 284°C (decomposition).
Therapeutic Function
Hepatoprotectant
References
[1] HE L, et al. Study on the Prevention Mechanism of Anti-tuberculosis Drug-induced Liver Injury with Orazamide Based on HMGB1-RAGE Signaling Pathway[J]. China Pharmacy, 2021: 2229-2235.
Orazamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22158 | 58 |
| Hunan Yuanye Pharmaceutical Co., Ltd. | +8615857615745 | 2675013845@qq.com | China | 87 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49983 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from Orazamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-31 | Orazamide USP/EP/BP
2574-78-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Orazamide USP/EP/BP
2574-78-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
