ZOTAROLIMUS
- CAS No.
- 221877-54-9
- Chemical Name:
- ZOTAROLIMUS
- Synonyms
- ABT 578;CS-1162;A 179578;Resolute;ZOTAROLIMUS;ZotaroliMus API;Unii-H4gxr80ize;Zotarolimus, >ZotaroliMus, >90%;ZotaroliMus(ABT-578)
- CBNumber:
- CB21011766
- Molecular Formula:
- C52H79N5O12
- Molecular Weight:
- 966.21
- MDL Number:
- MFCD09752954
- MOL File:
- 221877-54-9.mol
- MSDS File:
- SDS
| Melting point | 100-105°C |
|---|---|
| Boiling point | 1016.2±75.0 °C(Predicted) |
| Density | 1.25 |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO, Methanol (Slightly) |
| form | Solid |
| pka | 10.40±0.70(Predicted) |
| color | White to Pale Yellow |
| FDA UNII | H4GXR80IZE |
ZOTAROLIMUS price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29246 | Zotarolimus | 221877-54-9 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 29246 | Zotarolimus | 221877-54-9 | 25mg | $343 | 2024-03-01 | Buy |
| Cayman Chemical | 29246 | Zotarolimus | 221877-54-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29246 | Zotarolimus | 221877-54-9 | 10mg | $169 | 2024-03-01 | Buy |
| TRC | Z700800 | Zotarolimus,>90% | 221877-54-9 | 10mg | $145 | 2021-12-16 | Buy |
ZOTAROLIMUS Chemical Properties,Uses,Production
Description
Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin . It binds to FKBP prolyl isomerase 1A (FKBP12; IC50 = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (PBMCs), rat splenocytes, and human coronary artery smooth muscle cells (IC50s = 7, 1,337, and 0.8 nM, respectively). Zotarolimus has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s = 1.2 and 1,465 nM, respectively). It also reduces symptom severity in a rat model of experimental autoimmune encephalomyelitis (EAE; ED50 = 1.17 mg/kg per day) and delays cardiac allograft rejection in rats (ED50 = 3.71 mg/kg per day). Zotarolimus inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 μg/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis. Formulations containing zotarolimus have been used in drug-eluting stents in the prevention of restenosis following stent placement.
Chemical Properties
Pale Yellow Solid
Uses
A tetrazole-containing Rapamycin analog as immunomodulator and useful in the treatment of restenosis and immune and autoimmune diseases.
Uses
Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.
Definition
ChEBI: Zotarolimus is a macrolide and a lactam.
ZOTAROLIMUS Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9342 | 55 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28761 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Supplier | Advantage |
|---|---|
| Hangzhou FandaChem Co.,Ltd. | 55 |
| Biochempartner | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 58 |
| Career Henan Chemica Co | 58 |
| Dideu Industries Group Limited | 58 |
| BOC Sciences | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |