N-Bromosuccinimide

N-Bromosuccinimide Properties

Melting point	175-180 °C (dec.)(lit.)
Boiling point	221.4°C (rough estimate)
Density	2.098
vapor pressure	14.8 hPa (20 °C)
refractive index	1.6060 (estimate)
storage temp.	Store at +2°C to +8°C.
solubility	14.8g/l (decomposition)
pka	-2.78±0.20(Predicted)
form	Crystalline Powder
color	White to light yellow
Odor	characteristic odour of bromine
Water Solubility	Soluble in acetone, tetrahydrofuran, dimethyl formamide, dimethyl sulfoxide and acetonitrile. Slightly soluble in water and acetic acid. Insoluble in ether, hexane and carbon tetrachloride.
Sensitive	Moisture Sensitive
Merck	14,1438
BRN	113916
Stability	Stable. Incompatible with strong oxidizing agents, halogenated hydrocarbons.
InChIKey	PCLIMKBDDGJMGD-UHFFFAOYSA-N
LogP	-1.19
CAS DataBase Reference	128-08-5(CAS DataBase Reference)
FDA UNII	K8G1F2UCJF
NIST Chemistry Reference	2,5-Pyrrolidinedione, 1-bromo-(128-08-5)
EPA Substance Registry System	N-Bromosuccinimide (128-08-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS03,GHS05,GHS07,GHS08,GHS09

Signal word

Warning

Hazard statements

H272-H290-H315-H317-H319-H341-H400

Precautionary statements

P210-P273-P280-P302+P352-P305+P351+P338-P308+P313

Hazard Codes

C,Xn

Risk Statements

22-34-36/37/38

Safety Statements

26-36/37/39-45-37/39

RIDADR

UN 3261 8/PG 2

WGK Germany

3

Hazard Note

Harmful

TSCA

Yes

HazardClass

8

PackingGroup

III

HS Code

29251995

Toxicity

LD50 orally in Rabbit: > 2000 mg/kg

NFPA 704

	1
3		2
	OX

N-Bromosuccinimide price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B81255	N-Bromosuccinimide 99%	128-08-5	5g	$31.2	2024-03-01	Buy
Sigma-Aldrich	B81255	N-Bromosuccinimide 99%	128-08-5	1kg	$157	2024-03-01	Buy
Sigma-Aldrich	SAB4501957	Anti-p95 antibody produced in rabbit affinity isolated antibody	128-08-5	100μG	$506	2024-03-01	Buy
Sigma-Aldrich	8.01949	N-Bromosuccinimide for synthesis	128-08-5	5G	$42	2024-03-01	Buy
Sigma-Aldrich	8.01949	N-Bromosuccinimide for synthesis	128-08-5	250g	$86	2024-03-01	Buy

Product number	Packaging	Price	Buy
B81255	5g	$31.2	Buy
B81255	1kg	$157	Buy
SAB4501957	100μG	$506	Buy
8.01949	5G	$42	Buy
8.01949	250g	$86	Buy

N-Bromosuccinimide Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystalline powder

Uses

N-Bromosuccinimide is a brominated succinimide used as a chemical reagent in radical substitution and electrophilic addition reactions in organic synthesis. In bromination of olefins; in oxidation of alcohols to aldehydes and ketones and of aldehydes to acid bromides.

Definition

ChEBI: N-bromosuccinimide is a five-membered cyclic dicarboximide compound having a bromo substituent on the nitrogen atom. It has a role as a reagent. It is a dicarboximide, a pyrrolidinone and an organobromine compound. It is functionally related to a succinimide.

Preparation

N-Bromosuccinimide is prepared by addition of bromine to a cold aqueous solution of succinimide or by reaction of succinimide with NaBrO2 in the presence of HBr.
Preparation of N-bromosuccinimide
1.62mol (160g) succinimide is dissolved in a mixture of 1.60mol (64g) NaOH, 300g crushed ice and 400ml water. Cool the mixture in an ice bath, and add 85ml (1.65 mol, 264g) Br2 at once while stirring violently. Stir for two more minutes, then filter the precipitated product and wash with ice water. Dry in a desiccator. Yield 75-81%.
Don't clean up NBS too much, the stinky yellow stuff still containing a bit of Br2 works best. N-Bromosuccinimide is a brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by intraperitoneal route. An irritating poison to skin, eyes, and mucous membranes. Reacts explosively with adme, dtallyl sulfide, and hydrazine hydrate. Explosive reaction with propiononitrile after heating to 105℃ for 24 hours. Violent reaction with dtbenzoyl peroxide + 4-tok acid. When heated to decomposition it emits toxic fumes of Brand NOx. See also BROMIDES and NITROGEN MONOXIDE.

Purification Methods

N-Bromosuccinimide (30g) is purified by dissolving rapidly in 300mL of boiling water and filtering through a fluted filter paper into a flask immersed in an ice bath, and left for 2hours. The crystals are filtered off, washed thoroughly with ca 100mL of ice-cold water and drained on a Büchner funnel before drying under vacuun over P2O5 or CaCl2 [Dauben & McCoy J Am Chem Soc 81 4863 1959]. This brominating agent has also been crystallised from acetic acid or water (10 parts), washed in water and dried in vacuo [Wilcox et al. J Am Chem Soc 108 7693 1986, Shell et al. J Am Chem Soc 108 121 1986, Phillips & Cohen J Am Chem Soc 108 2013 1986, Beilstein 21/9 V 543.]

N-Bromosuccinimide synthesis

Synthesis of N-Bromosuccinimide from Succinimide

N-Bromosuccinimide Preparation Products And Raw materials

Raw materials

Succinimide Succinic acid

Preparation Products

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 5-Bromo-2-oxindole BISPYRAZOLONE 2-Amino-5-bromopyrazine Raltitrexed

METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE 4-CHLORO-3-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 3-BROMO-1-(TRIISOPROPYLSILYL)INDOLE 5-BROMO-2-CHLORO-4,6-DIMETHYLNICOTINONITRILE 2,6-Dibromopyridin-3-amine

5-BROMO-6-HYDROXY-1H-PYRIMIDINE-2,4-DIONE Ethyl 4-bromocrotonate 5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97% 2-Hydroxy-5-bromopyridine 3-Nitrobenzyl bromide

2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97% 2-NAPHTHALEN-1-YL-ETHYLAMINE METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE 5-BROMO-2-(PIPERIDIN-1-YL)PYRIMIDINE Methyl 3-(morpholinomethyl)benzoate ,98%

2-(Bromomethyl)pyridine hydrobromide 6-BROMOMETHYL-2-PYRIDINECARBOXYLIC ACID alpha,alpha'-Dibromo-p-xylene METHYL ALPHA-BROMOPHENYLACETATE IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID

Methyl 2-bromomethylbenzoate Bromoacetonitrile 4-Pyrazolecarboxylic acid 4-AMINO-N,N-DIMETHYLBENZYLAMINE 8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE 4-Bromo-2-methoxyphenol 3-(BROMOMETHYL)BENZOIC ACID 3-BROMO-5-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE DIETHYL 2-(ACETAMIDO)-2-(2-(BROMOMETHYL)-5-NITROBENZYL)MALONATE

4-BROMO-5-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 5-BROMO-4,6-DIMETHOXYPYRIMIDINE 2,5-DICHLOROTHIOPHENE-3-CARBOXYLIC ACID 5-BROMO-2-(MORPHOLIN-4-YL)PYRIMIDINE

1of8

N-Bromosuccinimide Suppliers

Global( 926)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Dangtong Import and export Co LTD	+8615632927689	admin@hbdangtong.com	China	991	58
Changzhou Zechong Biopharma Co., Ltd.	+undefined18621330623	sales@zechongchem.com	China	28	58
Hunan aslsen technology co.,ltd	+8619313031929	aslsd@aslsen.com	China	128	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-13102810335	admin@hbsaisier.cn	China	747	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2259	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55

Supplier	Advantage
Hebei Dangtong Import and export Co LTD	58
Changzhou Zechong Biopharma Co., Ltd.	58
Hunan aslsen technology co.,ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Jingbo New Material Technology Co., Ltd	58
Hebei Saisier Technology Co., LTD	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from N-Bromosuccinimide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	N-Bromosuccinimide 128-08-5	US $0.00 / KG	1KG	99%	2000mt	Jinan Finer Chemical Co., Ltd
2024-04-26	N-Bromosuccinimide 128-08-5	US $1.00-0.10 / kg	1kg	99%	300tons	Hebei Dangtong Import and export Co LTD
2024-04-26	N-Bromosuccinimide 128-08-5	US $7890.00-7870.00 / Metric tonnes	1Metric tonnes	99%	1000tons	Hebei Dangtong Import and export Co LTD

N-Bromosuccinimide
128-08-5
US $0.00 / KG
99%
Jinan Finer Chemical Co., Ltd

N-Bromosuccinimide
128-08-5
US $1.00-0.10 / kg
99%
Hebei Dangtong Import and export Co LTD

N-Bromosuccinimide
128-08-5
US $7890.00-7870.00 / Metric tonnes
99%
Hebei Dangtong Import and export Co LTD

N-Bromosuccinimide Spectrum

N-Bromosuccinimide(128-08-5)MS N-Bromosuccinimide(128-08-5)¹HNMR N-Bromosuccinimide(128-08-5)¹³CNMR N-Bromosuccinimide(128-08-5)IR1 N-Bromosuccinimide(128-08-5)IR2 N-Bromosuccinimide(128-08-5)Raman

128-08-5(N-Bromosuccinimide)Related Search:

Maleimide N-Iodosuccinimide Bismaleimide O-Phthalimide N-Hydroxysuccinimide

N-Chlorosuccinimide Succinimide N-BROMOACETAMIDE Mouse Serum NEWBORN BOVINE SERUM

Linalyl acetate DIMETHYLAMINE HYDROBROMIDE DIALIFOS PERKADOX PF-DBM25 Dibromantin Alternative to N-Bromosuccinimide,Dibromantin Alternative to N-Bromosuccinimide

ETHYLAMINE HYDROBROMIDE DIETHYLAMINE HYDROBROMIDE DIACETAMIDE

1of4

2,5-PYRROLIDINEDIONE, 1-BROMO- N-BROMOSUCCINIMIDE BROMOSUCCINIMIDE-N SUCCINIMIDE, N-BROMO- SUCCINBROMIDE SUCCINBROMIMIDE TIMTEC-BB SBB007826 1-bromo-5-pyrrolidinedione 5-Pyrrolidinedione,1-bromo-2 N-Bromosuccynimide N-BROMOSUCCINIMIDE pure N-Succinbromoimide AKOS BBS-00004413 N-Bromosuccinimide, extra pure N-BroMosucciniMide, 99% 100GR N-BroMosucciniMide, 99% 500GR NSC 16 N-BROMOSUCCINIMIDE FOR SYNTHESIS N-BroMosucciniMide ReagentPlus(R), 99% Anti-p95 antibody produced in rabbit Cell cycle regulatory protein P95 NIBRIN NIJMEGEN BREAKAGE syndrome protein 1 N-Bromosuccinimide 1-Bromopyrrolidine-2,5-dione, 1-Bromo-2,5-dioxopyrrolidine N-broMinatedbutyltwoiMide 1-Bromodihydro-1H-pyrrole-2,5-dione N-Bromosuccinimide≥ 99% (Titration) Succinibromimide N-bromo succinimde N-BROMOSUCCINIMIDE REAGENTPLUS(TM) 9& N-BROMOSUCCINIMIDE, REAGENTPLUS, 99% N-Bromosuccinimide99% 1-BROMO-2,5-PYRROLIDINEDIONE (N-BROMOSUCCINIMIDE) N-Bromo butanediimide Ozagrel Impurity 20 1-Bromo-2,5-pyrrolidinedione, NBS, N-bromobutanimide, N-бромбутанимид N-BROMOSUCCINIMIDE, 98%N-BROMOSUCCINIMIDE, 98%N-BROMOSUCCINIMIDE, 98%N-BROMOSUCCINIMIDE, 98% JACS-128-08-5 N-Bromosuccinimide > N-Bromosuccinimide, 99%, for synthesis N Bromo Succinamide (NBS) High purity N-bromosuccinimide cas:128-08-5 n-Bromosuccinimide for synthesis 100GM n-Bromosuccinimide for synthesis 500GM n-Bromosuccinimide, GR 99% N-Bromosuccinimide extrapure AR, ExiPlus, Multi-Compendial, 99% 1-BROMO-2,5-PYRROLIDINEDIONE N-BROMOSUCINIMIDE NBS N-BROMOBUTANIMIDE bromosuccinimide 1-Bromo-2,5-phrrolidinedione N-Bromsuccinimid N-Brom-succinimid N-Bromsuccinimide N-Bromosucciminide Ozagrel Sodium Impurity 20