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Phenytoin sodium

Phenytoin sodium
Phenytoin sodium structure
CAS No.
630-93-3
Chemical Name:
Phenytoin sodium
Synonyms
di-len;ditoin;epelin;epinat;eptoin;enkefal;tacosal;alepsin;dihydan;DILANTIN
CBNumber:
CB2304645
Molecular Formula:
C15H11N2NaO2
Formula Weight:
274.25
MOL File:
630-93-3.mol

Phenytoin sodium Properties

solubility 
aqueous base: soluble
form 
Crystalline Powder
color 
White to almost white
Merck 
14,7322
InChIKey
FJPYVLNWWICYDW-UHFFFAOYSA-M
CAS DataBase Reference
630-93-3(CAS DataBase Reference)
EPA Substance Registry System
2,4-Imidazolidinedione, 5,5-diphenyl-, monosodium salt(630-93-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H317-H361-H360
Precautionary statements  P201-P202-P264-P270-P308+P313-P405-P501-P280-P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-43-62-63
Safety Statements  22-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  MU1400000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29332100
Toxicity LD50 orally in mice: 490 mg/kg (Fink, Swinyard)

Phenytoin sodium price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D4505 5,5-Diphenylhydantoin sodium salt ≥99% 630-93-3 25g $49.4 2018-11-20 Buy
Sigma-Aldrich 1535507 Phenytoin sodium United States Pharmacopeia (USP) Reference Standard 630-93-3 200mg $348 2018-11-13 Buy
TCI Chemical D1331 5,5-Diphenylhydantoin Sodium Salt >98.0%(T) 630-93-3 25g $37 2018-11-22 Buy
TCI Chemical D1331 5,5-Diphenylhydantoin Sodium Salt >98.0%(T) 630-93-3 500g $221 2018-11-22 Buy
Sigma-Aldrich PHR1492 Phenytoin sodium Pharmaceutical Secondary Standard; Certified Reference Material 630-93-3 1g $66.9 2018-11-20 Buy

Phenytoin sodium Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder, slightly hygroscopic.

Uses

antibacterial

Uses

Antiepileptic

brand name

Diphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].

General Description

Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.

Clinical Use

Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.

Safety Profile

Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.

Carcinogenicity

Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.

Regulations

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Environmental Protection Agency (EPA)
Emergency Planning and Community Right-To-Know Act
Toxics Release Inventory: Listed substance subject to reporting requirements.
Food and Drug Administration (FDA)
Phenytoin is a prescription drug subject to labeling and other requirements.

Phenytoin sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Phenytoin sodium Suppliers

Global( 227)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21668 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 575 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 690 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Phenytoin sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-31 Phenytoin sodium
630-93-3
US $7.00 / KG 1KG 99% 100kg career henan chemical co

Phenytoin sodium Spectrum


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