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Benidipine

Benidipine Structure
Benidipine structure
CAS No.
105979-17-7
Chemical Name:
Benidipine
Synonyms
BENIDIPINE HCL;(R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride;KW-3049;5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-;CONIEL;CAPADIPINE;BENIDIPINE;NACADIPINE;rac Benidipine
CBNumber:
CB2131201
Molecular Formula:
C28H31N3O6
Molecular Weight:
505.56
MDL Number:
MFCD00906929
MOL File:
105979-17-7.mol
MSDS File:
SDS
Last updated:2023-05-04 15:12:06
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Benidipine Properties

Boiling point 625.2±55.0 °C(Predicted)
Density 1.29±0.1 g/cm3(Predicted)
pka pKa 7.34(H2O(long extrapolation) ) (Uncertain)
Water Solubility 316μg/L at 25℃
LogP 4.61
CAS DataBase Reference 105979-17-7(CAS DataBase Reference)
FDA UNII 4G9T91JS7E
ATC code C08CA15

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501

Benidipine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B157508 racBenidipine 105979-17-7 0.5mg $45 2021-12-16 Buy
American Custom Chemicals Corporation API0002106 CONIEL 95.00% 105979-17-7 100MG $693 2021-12-16 Buy
Medical Isotopes, Inc. 18512 Benidipine 105979-17-7 25mg $1500 2021-12-16 Buy
American Custom Chemicals Corporation API0002106 CONIEL 95.00% 105979-17-7 1G $1501.5 2021-12-16 Buy
AvaChem 3003B Benidipine 105979-17-7 100mg $89 2021-12-16 Buy
Product number Packaging Price Buy
B157508 0.5mg $45 Buy
API0002106 100MG $693 Buy
18512 25mg $1500 Buy
API0002106 1G $1501.5 Buy
3003B 100mg $89 Buy

Benidipine Chemical Properties,Uses,Production

Uses

Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.

Enzyme inhibitor

This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.

Benidipine Preparation Products And Raw materials

Raw materials

3,5-Pyridinedicarboxylic acid Methyl 3-aminocrotonate Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1-Benzyl-3-piperidinol

Preparation Products

Benidipine Suppliers

Global( 121)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5909 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9320 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9339 58
Supplier Advantage
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Shandong chuangyingchemical Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58

View Lastest Price from Benidipine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Benidipine pictures 2023-01-31 Benidipine
105979-17-7
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Benidipine USP/EP/BP pictures 2021-08-07 Benidipine USP/EP/BP
105979-17-7
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
Benidipine pictures 2021-07-13 Benidipine
105979-17-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Benidipine pictures
  • Benidipine
    105979-17-7
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Benidipine pictures
  • Benidipine
    105979-17-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

105979-17-7(Benidipine)Related Search:

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2-(Diethylamino)ethyl methacrylate 1-Benzyl-3-piperidinol hydrochloride Nitrendipine

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NACADIPINE BENIDIPINE CAPADIPINE CONIEL 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-(+-)- (+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate (R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester (4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester RAC Benidipine D7 Benidipine USP/EP/BP rac Benidipine (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester (R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel- BENIDIPINE HCL KW-3049 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 105979-17-7 C28H31N3O6HCl Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Pharmaceutical