Lincomycin | 154-21-2

Lincomycin Properties

Melting point	148-150°C
Boiling point	646.8±55.0 °C(Predicted)
Density	1.1704 (rough estimate)
refractive index	1.6510 (estimate)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water
form	Solid
pka	7.6(at 25℃)
color	White to Off-White
Stability	Hygroscopic
FDA 21 CFR	556.360; 558.325; 558.4
FDA UNII	BOD072YW0F
ATC code	J01FF02
NIST Chemistry Reference	Lincomycin(154-21-2)
EPA Substance Registry System	Lincomycin (154-21-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H335-H319
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Toxicity	LD50 oral in rat: 1gm/kg

Lincomycin price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21526	Lincomycin ≥98%	154-21-2	5mg	$130	2024-03-01	Buy
Cayman Chemical	21526	Lincomycin ≥98%	154-21-2	25mg	$479	2024-03-01	Buy
Usbiological	471018	Lincomycin	154-21-2	1mg	$595	2021-12-16	Buy
TRC	L466230	Lincomycin	154-21-2	100mg	$140	2021-12-16	Buy
TRC	L466230	Lincomycin	154-21-2	1g	$1070	2021-12-16	Buy

Product number	Packaging	Price	Buy
21526	5mg	$130	Buy
21526	25mg	$479	Buy
471018	1mg	$595	Buy
L466230	100mg	$140	Buy
L466230	1g	$1070	Buy

Lincomycin Chemical Properties,Uses,Production

Description

Lincomycin was isolated from a strain of Streptomyces lincolnensis in the Upjohn Research Laboratories. Lincosamides are also produced by S. roseolus, S. caelestis, and Monomicrospora halophytica. They consist of an amino acid connected to a sugar by an amide bond. It is available for intravenous, intramuscular, oral, and rectal use. Absorption after oral administration is up to one-third of the dose and plasma protein binding is around 75%. Because of the superior activity and bioavailability of clindamycin, lincomycin is now infrequently used clinically, but it is still available in some countries, in particular for skin and skin structure infections. Thus, the information in this chapter will primarily apply to clindamycin. Many chemical modifications of the lincomycin molecule have been developed and, of these, clindamycin (7-chloro-7-deoxylincomycin) is the most promising and clinically superior to lincomycin.

Description

Lincomycin is an antibiotic active against grampositive bacteria. Occupational exposure occurs in poultry and pig breeders.

Chemical Properties

White Crystalline Solid

Originator

Lincocin,Upjohn,UK,1964

Uses

An antibiotic produced by Streptomyces lincolnensis. Antibacterial

Uses

Lincomycin (Clindamycin Phosphate EP Impurity A) is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.This compound is a contaminant of emerging concern (CECs).

Uses

Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N-methylproline, coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

Definition

ChEBI: A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.

Manufacturing Process

As described in US Patent 3,086,912, the process comprises cultivating Streptomyces lincolnensis var. lincolnensis in an aqueous nutrient medium containing a source of assimilable carbohydrate and assimilable nitrogen under aerobic conditions until substantial activity is imparted to the medium by production of lincolnensin and isolating the lincolnensin so produced.

brand name

Lincocin (Pharmacia & Upjohn).

Therapeutic Function

Antibacterial

Antimicrobial activity

Lincomycin has an antibacterial effect with respect to Gram-positive microorganisms (staphylococci, streptococci, pneumococci, diphtheria bacillus, and clostridia). It is used for serious bacterial infections: sepsis, osteomyelitis, septic endocarditis, pneumonia, pulmonary abscess, infected wounds, and purulent meningitis. Lincomycin is a reserve drug for infections caused by strains of staphylococci and other Gram-positive microorganisms that are resistant to penicillin and other antibiotics. Synonyms of this drug are lincocin, mycivin, albiotic, and others.

General Description

Lincomycin was found in the culture broth of Streptomyces lincolnensis var. lincolnensis by the Upjohn Co. in 1962. It shows antibacterial activity similar to that of the macrolide antibiotics and also shows excellent activity against anaerobic bacteria. Lincomycin is used clinically in combination with other classes of antibiotics for postoperative, gynecological, urinary tract, ear and nose, and other infections.

Contact allergens

Lincomycin is an antibiotic of the lincosanide group，active against Gram-positive bacteria. Occupational exposure occurs in poultry and pig breeders

Clinical Use

Lincomycin is a natural product isolated from fermentations of Streptomyces lincolnensisvar. lincolnensis. It is active against Gram-positive organisms, including some anaerobes. It is indicated for the treatment of serious infections caused by sensitive strains of streptococci, pneumococci, and staphylococci. It generally is reserved for patients who are allergic to penicillin because of the increased risk of pseudomembranous colitis. It also serves as the starting material for the synthesis of clindamycin (by a SN-2 reaction that inverts the R stereochemistry of the C-7 hydroxyl to a C-7 S-chloride).

Synthesis

Lincomycin, 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidincarboxamido)-1-methylthio-D-erythro-α-D-galacto-octopyranoside (32.5.1), is the first lincosamide that has found use in clinical practice, and which was isolated in 1962 from the culture liquid of the activity of the actinomycete Streptomyces lincolnensis.

Veterinary Drugs and Treatments

Lincomycin has dosage forms approved for use in dogs, cats, swine, and in combination with other agents for chickens. Because clindamycin is generally better absorbed, more active, and probably less toxic, it has largely supplanted the use of lincomycin for oral and injectable therapy in small animals, but some clinicians believe that clindamycin does not offer enough clinically significant improvements over lincomycin to justify its higher cost. For further information, refer to the Pharmacology or Doses sections.

Lincomycin synthesis

Synthesis of Lincomycin from Lincomycin hydrochloride

Lincomycin Preparation Products And Raw materials

Raw materials

LINDANE Methyl 6,8-Dideoxy-6-[[[(2S,4R)-1-Methyl-4-propyl-2-pyrrolidinyl]carbonyl]aMino]-1-thio-2,3,4-tris-O-(triMethylsilyl)-D-erythro-α-D-galacto-octopyranoside Lincomycin hydrochloride

Preparation Products

Clindamycin hydrochloride

Lincomycin Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD	+8617731987558	xingjiu@xingjiubiotech.com	China	990	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58

Supplier	Advantage
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Capot Chemical Co.,Ltd.	60
Hangzhou FandaChem Co.,Ltd.	55
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Lincomycin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	Lincomycin 154-21-2	US $15.00 / kg	1kg	99.912%	10ton	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-26	Lincomycin 154-21-2	US $21.00 / Grams	1000Grams	99.99%	100Tons	Hebei Dangtong Import and export Co LTD
2024-04-10	Lincomycin 154-21-2	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC

Lincomycin
154-21-2
US $15.00 / kg
99.912%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Lincomycin
154-21-2
US $21.00 / Grams
99.99%
Hebei Dangtong Import and export Co LTD

Lincomycin
154-21-2
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

154-21-2(Lincomycin )Related Search:

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U-10149A LINCOMYCIN STANDARD LINCOMYCIN LYNCOMYCIN Lincomycin HCL Bp98 USP24 EPIII CP2000 Lincomycin(baseand/orunspecifiedsalt) Albiotic Cillimycin NSC-70731 trans-alpha trans-alpha-opyl-2-pyrrolidinyl)carbonyl)amino)-1-thio trans-alpha--pyrrolidinecarboxamido)-1-thio U-10149 (2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)- D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- (9CI) D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-a- (8CI) Lincomycin (base and/or unspecified salts) Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-alpha-D-gluco-octopyranoside (2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-α-D-galacto-octopyranoside Hydrochloride (2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside Hydrochloride d-erythro-alpha-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(((1-methyl-4-pr D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans- alpha- d-erythro-d-galacto-octopyranoside,methyl-6,8-dideoxy-6-(1-methyl-4-propyl-l-2 d-erythro-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(1-methyl-4-propyl-l-2 hro-d-galacto-octopyranoside(alpha-form) jiemycin Lincocine Lincolcina Lincolnensin lincomycina Lincomyocin Methyl 6,8-dideoxy-6-([(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino)-1-thiooctopyranoside Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-oxan-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide Methyl-D-erythro-a-D-galacto-octopyranoside Myvicin Linocin, Lincolnensin, U 10149, JieMycin Clindamycin Phosphate EP Impurity A （Clindamycin HCl EP Impurity A） Clindamycin Phosphate EP Impurit A methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propylpyrrolidin-2yl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside Clindamycin Impurity 10（Clindamycin Phosphate） Clindamycin HCl EP Impurity A ） Clindamycin Phosphate EP Impurity A/Lincomycin/(2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-a-D-galactooctopyranoside hydrochloride Clindamycin EP Impurity A Clindamycin Phosphate EP Impurity A Clindamycin Phosphate EP Impurities Clindamycin Impurity 10(Clindamycin Phosphate EP Impurity A (2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl ]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- Clindamycin EP Impurity A (Lincomycine) Lincomycin USP/EP/BP Clindamycin Impurity 10（Clindamycin Phosphate EP Impurity A，Clindamycin HCl EP Impurity A ） Lincomycin(base) Clindamycin Hydrochloride EP Impurity A Clindamycin Phosphate Impurity A Clindamycin Phosphate Impurity A(EP)