Xylazine Hydrochloride

CAS No.
23076-35-9
Chemical Name:
Xylazine Hydrochloride
Synonyms
XYLAZINE HCL;XYLAZIN HYDROCHLORIDE;2-(2,6-DIMETHYLPHENYLAMINO)-5,6-DIHYDRO-4H-THIAZINE HYDROCHLORIDE;N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazine-2-aminehydrochloride;rompun;celactal;Rompun[R];245-417-0;bay-va1470;xylazinechloride
CBNumber:
CB3477355
Molecular Formula:
C12H17ClN2S
Molecular Weight:
256.79
MDL Number:
MFCD00058196
MOL File:
23076-35-9.mol
MSDS File:
SDS
Last updated:2024-01-25 17:55:40

Xylazine Hydrochloride Properties

Melting point 150-164?C (dec.)
storage temp. 2-8°C
solubility ≥12.84 mg/mL in DMSO; ≥24.1 mg/mL in EtOH; ≥24.15 mg/mL in H2O
color White to Almost white
Water Solubility Soluble in water
Merck 14,10080
BRN 6448471
InChI InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
InChIKey QYEFBJRXKKSABU-UHFFFAOYSA-N
SMILES N(C1SCCCN=1)C1C(=CC=CC=1C)C.Cl
CAS DataBase Reference 23076-35-9(CAS DataBase Reference)
FDA UNII NGC3S0882S

SAFETY

Risk and Safety Statements

NFPA 704
0
2 0

Xylazine Hydrochloride price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR3264 Xylazine Hydrochloride pharmaceutical secondary standard, certified reference material 23076-35-9 500MG $151 2022-05-15 Buy
Sigma-Aldrich 46995 Xylazine hydrochloride VETRANAL , analytical standard 23076-35-9 100mg $54.5 2022-05-15 Buy
Sigma-Aldrich 1720429 Xylazine hydrochloride United States Pharmacopeia (USP) Reference Standard 23076-35-9 200mg $400 2022-05-15 Buy
TCI Chemical X0059 Xylazine Hydrochloride >98.0%(HPLC)(T) 23076-35-9 5g $98 2023-06-20 Buy
TCI Chemical X0059 Xylazine Hydrochloride >98.0%(HPLC)(T) 23076-35-9 25g $296 2023-06-20 Buy
Product number Packaging Price Buy
PHR3264 500MG $151 Buy
46995 100mg $54.5 Buy
1720429 200mg $400 Buy
X0059 5g $98 Buy
X0059 25g $296 Buy

Xylazine Hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Xylazine Hydrochloride is an alpha-2 agonist with sedative, analgesic, and muscle relaxant properties. It is approved for use in dogs,cats,horses,deer,and elk. This agent causes vomiting in a large percentage of cats and in some dogs. Xylazine is antagonized by yohimbine. It produces effective analgesia in horses and is often used for treating the pain associated with colic and for sedation for minor procedures.It is also used in combination with ketamine for short-term feld procedures in horses,such as castration and suturing of extensive wounds,because this combination usually produces 15 to 20 minutes of recumbency. Extralabel use of xylazine for cesarean sections in cattle and other surgical procedures is common. Xylazine Hydrochloride is used in cats and dogs as a tranquilizer and in combination with other injectable agents for surgical procedures.

Definition

ChEBI: Xylazine hydrochloride is the hydrochloride salt of xylazine. It is used as a sedative, analgesic, and muscle relaxant in veterinary medicine. It has a role as an alpha-adrenergic agonist, an analgesic, an emetic, a muscle relaxant and a sedative. It contains a xylazine(1+).

brand name

Rompun (Bayer Animal Health).

Biological Activity

Xylazine Hydrochloride is a strong agonist of α2-adrenoceptor [1].xylazine hcl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mm) [2]. in the analgesic testing, xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. in addition, xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the ic50 value of 18nm. furthermore, xylazine has displayed a potent specific [3h]-dihydromorphine binding inhibition with the ic50 value of 8μm in opiate receptor binding test [1].

Biochem/physiol Actions

Xylazine is used as a sedative in goats as it is safe, active and a cheap drug. It is a centrally acting drug, which exhibits muscle relaxant and analgesic properties.

Side effects

Respiratory depression, low blood pressure, slowed heart rate, hypothermia, pupil constriction and, sometimes, high blood sugar levels.
The pupil constriction and respiratory depression are particularly of concern, as these are very common and widely understood effects of an opioid overdose.
Severe, necrotic skin ulcerations are the most striking side effect of xylazine. Notably, while these skin ulcerations may appear at the site of injection, they may appear at a completely different site on the body altogether. Soft tissue infections are often associated with IV drug use of more conventional illicit substances such as opioids, but these are almost always located at the injection site.

Veterinary Drugs and Treatments

Xylazine Hydrochloride is approved for use in dogs, cats, horses, deer, and elk. It is indicated in dogs, cats, and horses to produce a state of sedation with a shorter period of analgesia, and as a preanesthetic before local or general anesthesia. Because of the emetic action of xylazine in cats, it is occasionally used to induce vomiting after ingesting toxins.

References

[1] s. browning, d.lawrence1, a.livingston & b.morris. interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] colić m1, cupić v, pavicić l, vucević d, varagić vm. xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. methods find exp clin pharmacol. 2000 sep;22(7):557-62.

Xylazine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products