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Levothyroxine sodium

Levothyroxine sodium
Levothyroxine sodium structure
CAS No.
55-03-8
Chemical Name:
Levothyroxine sodium
Synonyms
Levothyroxine Sdium;Levothyroxine sodium;Levothyroxine sodium ,T4;L-ThyroxineSodiumSaltB.P.;L-THYROXINE SODIUM ANHYDROUS;levothyroxine sodium anhydrous;L-THYROXINE SODIUM PENTAHYDRATE;L-THYROXINE SODIUM SALT PENTAHYDRATE;L-Thyroxine Sodium Salt Pentahydrate;Sodium 4-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
CBNumber:
CB4106276
Molecular Formula:
C15H20I4NNaO9
Formula Weight:
888.93
MOL File:
55-03-8.mol

Levothyroxine sodium Properties

Melting point:
207-210 (dec.)(lit.)
alpha 
D20 -4.4° (c = 3 in 70% ethanol)
Density 
d420 2.381
storage temp. 
2-8°C
solubility 
cell culture medium: 0.1 mg/mL
form 
powder
InChIKey
JMHCCAYJTTWMCX-QWPJCUCISA-M
EPA Substance Registry System
L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)- 3,5-diiodo-, monosodium salt(55-03-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Safety Statements  22-24/25
RIDADR  2811
WGK Germany  3
RTECS  YP2833760
3-8-10
HazardClass  6.1(a)
PackingGroup  II
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P405 Store locked up.
P501 Dispose of contents/container to..…

Levothyroxine sodium price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate >98.0%(T) 55-03-8 1g $39 2018-11-22 Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate >98.0%(T) 55-03-8 100mg $13 2018-11-22 Buy

Levothyroxine sodium Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

Definition

ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.

brand name

Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).

General Description

Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.

Clinical Use

Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.

Levothyroxine sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Levothyroxine sodium Suppliers

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Levothyroxine sodium Spectrum


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