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Levothyroxine sodium

Levothyroxine sodium Structure
Levothyroxine sodium structure
CAS No.
55-03-8
Chemical Name:
Levothyroxine sodium
Synonyms
L-THYROXINE SODIUM PENTAHYDRATE;L-THYROXINE SODIUM SALT PENTAHYDRATE;L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodiumsalt;LT4 sodium;L-T4 sodium;Levothyroxine Sdium;Levothyroxine sodium;Thyroxine Soduim Salt;Levothyroxine sodium ,T4;L-ThyroxineSodiumSaltB.P.
CBNumber:
CB4106276
Molecular Formula:
C15H12I4NNaO4
Molecular Weight:
800.87
MDL Number:
MFCD00149110
MOL File:
55-03-8.mol
Last updated:2024-03-28 17:11:29
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Levothyroxine sodium Properties

Melting point 207-210 (dec.)(lit.)
alpha D20 -4.4° (c = 3 in 70% ethanol)
Density d420 2.381
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility cell culture medium: 0.1 mg/mL
form powder
BCS Class 1,3
Stability Hygroscopic
InChIKey JMHCCAYJTTWMCX-QWPJCUCISA-M
FDA UNII 9J765S329G
ATC code H03AA01
NCI Drug Dictionary levothyroxine sodium
EPA Substance Registry System Levothyroxine sodium (55-03-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS07
Signal word  Danger
Hazard statements  H301+H311-H315-H319
Precautionary statements  P264-P270-P280-P301+P310+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P405-P501
Safety Statements  22-24/25
RIDADR  2811
WGK Germany  3
RTECS  YP2833760
F  3-8-10
HazardClass  6.1(a)
PackingGroup  II
HS Code  2937909000

Levothyroxine sodium price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate >98.0%(T) 55-03-8 1g $40 2021-12-16 Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate >98.0%(T) 55-03-8 100mg $14 2021-12-16 Buy
TRC T425601 ThyroxineSodiumSalt 55-03-8 10g $275 2021-12-16 Buy
Medical Isotopes, Inc. 53167 ThyroxineSodiumSalt 55-03-8 1g $610 2021-12-16 Buy
American Custom Chemicals Corporation API0007805 LEVOTHYROXINE SODIUM 95.00% 55-03-8 1G $704.55 2021-12-16 Buy
Product number Packaging Price Buy
T0245 1g $40 Buy
T0245 100mg $14 Buy
T425601 10g $275 Buy
53167 1g $610 Buy
API0007805 1G $704.55 Buy

Levothyroxine sodium Chemical Properties,Uses,Production

Chemical Properties

Levothyroxine sodium is White Solid

Originator

Synthroid,Flint,US,1953

Uses

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

Indications

Levothyroxine sodium (Levothroid, Synthroid, Levoxine) is the sodium salt of the naturally occurring levorotatory isomer of T4. It is the preparation of choice for maintenance of plasma T4 and T3 concentrations for thyroid hormone replacement therapy in hypothyroid patients. It is absorbed intact from the gastrointestinal tract, and its long half-life allows for convenient oncedaily administration. Since much of the T4 is deiodinated to T3, it is usually unnecessary to use more expensive preparations containing both T4 and T3.The aim is to establish euthyroidism with measured serum concentrations of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.

Definition

ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.

Manufacturing Process

A 9.30 g portion of N-acetyl-L-diiodotyrosinamide was suspended in 100 ml of 0.05M boric acid (H3BO3) and 100 ml of 95% ethanol, and the solid was dissolved by adjusting the pH to 10.5 with 2N sodium hydroxide (NaOH). A 15% (by weight) portion of manganese sulfate monohydrate was added and the solution heated at 44°C under conditions of oxygenation while being agitated mechanically. After approximately 24 hours of incubation, the precipitated product was collected and separated from the catalyst, providing the amide of N-acetyl-L-thyroxine in 30.6% yield. On hydrolysis (removal of both amide functions), achieved by refluxing in glacial acetic acid-hydrochloric acid (approximately 2:1), L-thyroxine is obtained. It was isolated as the sodium salt, containing approximately 5 molecules of water of hydration.

brand name

Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).

Therapeutic Function

Thyroid hormone

General Description

Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.

Clinical Use

Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.

Veterinary Drugs and Treatments

Levothyroxine sodium is indicated for the treatment of hypothyroidism in all species.

Levothyroxine sodium Preparation Products And Raw materials

Raw materials

L-Thyroxine Acetic acid Sodium levothyroxine Sodium hydroxide Hydrochloric acid
Manganese sulfate monohydrate IodoniuM,bis(4-Methoxyphenyl)-,iodide bis(p-methoxyphenyl)iodonium bromide N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate
L-Tyrosine,3,5-diiodo-o-(4-Methoxyphenyl) N-Acetyl-3,5-diiodo-L-tyrosine 3,5-Diiodo-L-tyrosine dihydrate

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Preparation Products

Levothyroxine sodium Suppliers

Global( 267)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Lingding Biotechnology Co., Ltd. 		+86-18031140164 +86-19933155420 erin@hbldbiotech.com China 878 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Shanghai Longyu Biotechnology Co., Ltd. 		+8615821988213 info@longyupharma.com China 2531 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
Hebei shuoxi biotechnology co. LTD 		+8613081092107 CHINA 968 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Supplier Advantage
Hebei Lingding Biotechnology Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
Shanghai Longyu Biotechnology Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
Hebei shuoxi biotechnology co. LTD 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58

View Lastest Price from Levothyroxine sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Levothyroxine sodium pictures 2024-03-28 Levothyroxine sodium
55-03-8
 US $80.00-71.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biotechnology Co., Ltd.
Levothyroxine sodium pictures 2023-06-15 Levothyroxine sodium
55-03-8
 US $3095.00 / Kg/Bag 1KG 99 1T Baoji Guokang Bio-Technology Co., Ltd.
Levothyroxine sodium pictures 2023-05-12 Levothyroxine sodium
55-03-8
 US $0.00-0.00 / kg 1kg 98% kg grade Suzhou Ryan Pharmachem Technology Co.,Ltd.

Levothyroxine sodium Spectrum

Levothyroxine sodium(55-03-8)1HNMRLevothyroxine sodium(55-03-8)IR1

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Levothyroxine sodium Sodium 4-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid odium (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic acid sodium salt sodium (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate L-THYROXINE SODIUM ANHYDROUS Levothyroxine Sdium levothyroxine sodium anhydrous (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt Sodium (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate sodiuM (S)-2-aMino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodiuM salt (1:1) SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE L-Thyroxine Sodium Salt Pentahydrate 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE Levothyroxine sodium ,T4 3-Amino-4-(4-(4-OH-3,5-diiodophenoxy)-3,5-diiodophenyl))but.ac.Na salt L-ThyroxineSodiumSaltB.P. LT4 sodium L-T4 sodium Levothyroxine sodium USP/EP/BP levothyroxine sodium anhydrousdium anhydrous Levothyroxine SodiumQ: What is Levothyroxine Sodium Q: What is the CAS Number of Levothyroxine Sodium Q: What is the storage condition of Levothyroxine Sodium Q: What are the applications of Levothyroxine Sodium (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt Pentahydrate L-THYROXINE SODIUM SALT PENTAHYDRATE L-THYROXINE SODIUM PENTAHYDRATE L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodiumsalt Thyroxine Soduim Salt 55-03-8 55-03-86106-07-6 C15H10I4NNaO45H2O C15H10I4NO4Na C15H11I4NNaO4 Other Protein/Peptide Hormones Hormones Thyroxine (T4) Cytokines, Growth Factors and Hormones Cell Signaling and Neuroscience Cell Biology BioChemical Amino Acids & Derivatives Aromatics Amino Acids Biochemistry Biological-modified Amino Acids Medicine intermediate Intermediates & Fine Chemicals Pharmaceuticals Steroid and Hormone 55-03-8