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Levothyroxine sodium

Levothyroxine sodium
Levothyroxine sodium structure
CAS No.
55-03-8
Chemical Name:
Levothyroxine sodium
Synonyms
LT4 sodium;L-T4 sodium;Levothyroxine Sdium;Levothyroxine sodium;Levothyroxine sodium ,T4;L-ThyroxineSodiumSaltB.P.;L-THYROXINE SODIUM ANHYDROUS;levothyroxine sodium anhydrous;Levothyroxine sodium USP/EP/BP;L-THYROXINE SODIUM PENTAHYDRATE
CBNumber:
CB4106276
Molecular Formula:
C15H20I4NNaO9
Formula Weight:
888.93
MOL File:
55-03-8.mol

Levothyroxine sodium Properties

Melting point:
207-210 (dec.)(lit.)
alpha 
D20 -4.4° (c = 3 in 70% ethanol)
Density 
d420 2.381
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
cell culture medium: 0.1 mg/mL
form 
powder
InChIKey
JMHCCAYJTTWMCX-QWPJCUCISA-M
FDA UNII
9J765S329G
NCI Drug Dictionary
levothyroxine sodium
EPA Substance Registry System
Levothyroxine sodium (55-03-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS07
Signal word  Danger
Hazard statements  H301+H311-H315-H319
Precautionary statements  P264-P270-P280-P301+P310+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P405-P501
Safety Statements  22-24/25
RIDADR  2811
WGK Germany  3
RTECS  YP2833760
3-8-10
HazardClass  6.1(a)
PackingGroup  II
HS Code  2937909000

Levothyroxine sodium price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1365065 Levothyroxine sodium United States Pharmacopeia (USP) Reference Standard 55-03-8 50 mg $366 2021-03-22 Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate >98.0%(T) 55-03-8 1g $40 2020-06-24 Buy
TCI Chemical T0245 L-Thyroxine Sodium Salt Pentahydrate >98.0%(T) 55-03-8 100mg $14 2020-06-24 Buy

Levothyroxine sodium Chemical Properties,Uses,Production

Chemical Properties

Levothyroxine sodium  is White Solid

Originator

Synthroid,Flint,US,1953

Uses

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

Definition

ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.

Indications

Levothyroxine sodium (Levothroid, Synthroid, Levoxine) is the sodium salt of the naturally occurring levorotatory isomer of T4. It is the preparation of choice for maintenance of plasma T4 and T3 concentrations for thyroid hormone replacement therapy in hypothyroid patients. It is absorbed intact from the gastrointestinal tract, and its long half-life allows for convenient oncedaily administration. Since much of the T4 is deiodinated to T3, it is usually unnecessary to use more expensive preparations containing both T4 and T3.The aim is to establish euthyroidism with measured serum concentrations of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.

Manufacturing Process

A 9.30 g portion of N-acetyl-L-diiodotyrosinamide was suspended in 100 ml of 0.05M boric acid (H3BO3) and 100 ml of 95% ethanol, and the solid was dissolved by adjusting the pH to 10.5 with 2N sodium hydroxide (NaOH). A 15% (by weight) portion of manganese sulfate monohydrate was added and the solution heated at 44°C under conditions of oxygenation while being agitated mechanically. After approximately 24 hours of incubation, the precipitated product was collected and separated from the catalyst, providing the amide of N-acetyl-L-thyroxine in 30.6% yield. On hydrolysis (removal of both amide functions), achieved by refluxing in glacial acetic acid-hydrochloric acid (approximately 2:1), L-thyroxine is obtained. It was isolated as the sodium salt, containing approximately 5 molecules of water of hydration.

brand name

Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).

Therapeutic Function

Thyroid hormone

General Description

Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.

Clinical Use

Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.

Veterinary Drugs and Treatments

Levothyroxine sodium is indicated for the treatment of hypothyroidism in all species.

Levothyroxine sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Levothyroxine sodium Suppliers

Global( 183)Suppliers
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Capot Chemical Co.,Ltd.
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View Lastest Price from Levothyroxine sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 Levothyroxine sodium
55-03-8
US $0.00 / Kg/Bag 100g 97%-103% HPLC 10KGS WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-31 Levothyroxine sodium
55-03-8
US $10.00 / KG 25Kg/Drum 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2021-07-22 Levothyroxine sodium
55-03-8
US $3095.00 / Kg/Bag 1KG 99 1T Baoji Guokang Bio-Technology Co., Ltd.

Levothyroxine sodium Spectrum


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