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Phloretin

Phloretin
Phloretin structure
CAS No.
60-82-2
Chemical Name:
Phloretin
Synonyms
Floretin;Phloretol;PHLORETIN;RJC 02792;Asebogenol;NSC 407292;Phloretin,98%;PHLORETIN(RG);Dihydronaringenin;Phloretin 60-82-2
CBNumber:
CB4161608
Molecular Formula:
C15H14O5
Formula Weight:
274.27
MOL File:
60-82-2.mol

Phloretin Properties

Melting point:
~260 °C
Boiling point:
337.26°C (rough estimate)
Density 
1.1827 (rough estimate)
FEMA 
4390 | 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE
refractive index 
1.573-1.575
storage temp. 
2-8°C
form 
Powder
color 
White to beige
Water Solubility 
soluble
JECFA Number
2022
Merck 
14,7326
BRN 
1887240
InChIKey
VGEREEWJJVICBM-UHFFFAOYSA-N
CAS DataBase Reference
60-82-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26-36
WGK Germany  3
3-10
HazardClass  IRRITANT
HS Code  29145090
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Phloretin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 91897 Phloretin analytical standard 60-82-2 10mg $63.1 2018-11-13 Buy
Sigma-Aldrich 524488 Phloretin A cell-permeable inhibtor of protein kinase C (IC = 20-50 μM). 60-82-2 200mg $130 2018-11-20 Buy
TCI Chemical P1966 Phloretin >98.0%(HPLC) 60-82-2 1g $126 2018-11-22 Buy
TCI Chemical P1966 Phloretin >98.0%(HPLC) 60-82-2 5g $424 2018-11-22 Buy
Alfa Aesar L10991 Phloretin, 98% 60-82-2 100mg $65 2018-11-13 Buy

Phloretin Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Chemical Properties

White to pale yellow solid.

Uses

A calcium channel protein inhibitor.

Uses

The aglucon of Phlorizin. A glucose transport inhibitor. Also inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts.

Uses

antidiabetic, inhibits glucose transport

Uses

antioxidant cosmetic use

Definition

ChEBI: A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.

Enzyme inhibitor

This naturally occurring aglucon (FW = 274.27 g/mol; CAS 60-82-2) of phlorizin (or phloridzin) is generated from the latter by the action of bglucosidases, the phlorizin hydrolase activity of lactase, and by dilute mineral acids. Phloretin is soluble in ethanol and acetone. It is almost insoluble in water; however, the solubility is increased upon addition of ethanol. It adsorbs to lipid surfaces and alters the dipole potential of lipid monolayers and bilayers. Adsorption to biological and artificial membranes results in a change of the membrane permeability for a variety of charged and neutral compounds. Target(s): aldose 1-epimerase, or mutarotase; ATPases, chloroplast; Ca2+ channels, L-type; Ca2+- dependent ATPase; cAMP phosphodiesterase; b-carotene 15,15’- monooxygenase; chalcone isomerase; electron transport, chloroplast; fatty-acid synthase; glucose transport; glycogen phosphorylase; inositol-trisphosphate 3-kinase; iodothyronine deiodinase; lactate transport; L-leucine transport; Na+ and K+ uptake; oxidative phosphorylation (mitochondrial), uncoupler; phenylpyruvate tautomerase; photophosphorylation; prostaglandin F2a receptor; protein kinase C; pyruvate transport; starch phosphorylase; a,a-trehalase; tyrosinase, or monophenol monooxygenase; urea transport; and water permeability.

Purification Methods

Crystallise phloretin from aqueous EtOH. [Zemplen & Bognár Chem Ber 75 1040 1942, Zemplén Chem Ber 76 386 1943, Beilstein 8 IV 3518.]

Phloretin Preparation Products And Raw materials

Raw materials

Preparation Products


Phloretin Suppliers

Global( 232)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
NanJing Spring & Autumn Biological Engineering CO., LTD.
13815411950
0086-25-83337318 sale03@cqherb.com CHINA 354 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
13815411950
0086-25-83337318 sale03@cqherb.com CHINA 354 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21915 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20675 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32451 55
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4002 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25795 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58

View Lastest Price from Phloretin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 Phloretin 60-82-2
60-82-2
US $25.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2019-07-11 Phloretin 60-82-2
60-82-2
US $25.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2018-08-20 Phloretin
60-82-2
US $2.00 / KG 1KG 98% 1 ton career henan chemical co

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