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2-Bromo-6-chlorobenzoic acid

2-Bromo-6-chlorobenzoic acid Structure
2-Bromo-6-chlorobenzoic acid structure
CAS No.
93224-85-2
Chemical Name:
2-Bromo-6-chlorobenzoic acid
Synonyms
AKOS MSC-0781;BUTTPARK 51\01-28;2-Bromo-6-chlorobenzoicaci;6-bromo-2-chloroBenzoic acid;2-BROMO-6-CHLOROBENZOIC ACID;3-bromo-2-chloro-benzoic acid;Benzoic acid, 2-broMo-6-chloro-;2-Bromo-6-chlorobenzoic acid, CAS 93224-85-2;2-Bromo-6-chlorobenzoic acid ISO 9001：2015 REACH
CBNumber:
CB4236698
Molecular Formula:
C7H4BrClO2
Molecular Weight:
235.46
MDL Number:
MFCD00672929
MOL File:
93224-85-2.mol
MSDS File:
SDS
Last updated:2026-01-13 11:21:30
Product description Number Pack Size Price
2-Bromo-6-chlorobenzoic Acid min. 98.0 % B4820 1G $24
2-Bromo-6-chlorobenzoic Acid min. 98.0 % B4820 5G $70
2-Bromo-6-chlorobenzoic acid B682535 25g $450
2-Bromo-6-chlorobenzoic acid 2621-D-02 100g $504
2-Bromo-6-chlorobenzoic acid FB139787 250g $577.5
More product size
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2-Bromo-6-chlorobenzoic acid Properties

Melting point 148-152 °C
Boiling point 315.9±27.0 °C(Predicted)
Density 1.809±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
pka 1.62±0.10(Predicted)
form powder to crystal
color White to Orange to Green
InChI 1S/C7H4BrClO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11)
InChIKey URGXUQODOUMRFP-UHFFFAOYSA-N
SMILES OC(=O)c1c(Cl)cccc1Br
CAS DataBase Reference 93224-85-2(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P280a-P304+P340-P405-P501a-P261-P301+P310-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes  Xi,T
Risk Statements  25-36/37/38
Safety Statements  26-45
RIDADR  2811
WGK Germany  2
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  2916399090
Storage Class 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2-Bromo-6-chlorobenzoic acid price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B4820 2-Bromo-6-chlorobenzoic Acid min. 98.0 % 93224-85-2 1G $24 2026-04-30 Buy
TCI Chemical B4820 2-Bromo-6-chlorobenzoic Acid min. 98.0 % 93224-85-2 5G $70 2026-04-30 Buy
TRC B682535 2-Bromo-6-chlorobenzoic acid 93224-85-2 25g $450 2021-12-16 Buy
SynQuest Laboratories 2621-D-02 2-Bromo-6-chlorobenzoic acid 93224-85-2 100g $504 2021-12-16 Buy
Biosynth Carbosynth FB139787 2-Bromo-6-chlorobenzoic acid 93224-85-2 250g $577.5 2021-12-16 Buy
Product number Packaging Price Buy
B4820 1G $24 Buy
B4820 5G $70 Buy
B682535 25g $450 Buy
2621-D-02 100g $504 Buy
FB139787 250g $577.5 Buy

2-Bromo-6-chlorobenzoic acid Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

2-Bromo-6-chlorobenzoic acid is used in the syntheis of Diclofenac Monobromo Sodium Salt Impurity (D436490).

Synthesis

3-BROMOCHLOROBENZENE

108-37-2

Carbon dioxide

124-38-9

2-Bromo-6-chlorobenzoic acid

93224-85-2

Step 1. Synthesis of 2-bromo-6-chlorobenzoic acid: Diisopropylamine (3.5 mL, 25 mmol) was slowly added to a tetrahydrofuran (THF, 70 mL) solution of n-butyllithium (n-BuLi, 10 mL, 25 mmol, 2.5 M hexane solution) cooled at -78 °C under anhydrous conditions. After stirring the reaction mixture for 15 minutes, 1-chloro-3-bromobenzene (4.32 g, 25 mmol) was added dropwise and stirring was continued at -78 °C for 2 hours. Subsequently, dry ice (solid CO2) was added to the reaction system and after 15 min of reaction, aqueous 2N hydrochloric acid (100 mL) was slowly added to quench the reaction. The reaction mixture was extracted with ethyl acetate (EtOAc) and the organic phases were combined. The product was purified by recrystallization from hexane and finally isolated to give 5 g of 2-bromo-6-chlorobenzoic acid in 85% yield.

References

[1] Organic Letters, 2009, vol. 11, # 5, p. 1051 - 1054
[2] Tetrahedron Letters, 1997, vol. 38, # 9, p. 1559 - 1562
[3] Patent: WO2008/124582, 2008, A1. Location in patent: Page/Page column 117
[4] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 108
[5] Organic Process Research and Development, 2005, vol. 9, # 6, p. 764 - 767

2-Bromo-6-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

3-BROMOCHLOROBENZENE Carbon dioxide Tetrahydrofuran petroleum ether 40 60 Diisopropylamine
n-Butyllithium Hydrochloric acid

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Preparation Products

2-Bromo-6-chlorobenzoic acid Suppliers

Global( 257)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Speranza Chemical Co., Ltd. 		+86-86-075521030354 +8618688942810 sophieliu@speranzachem.com China 923 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2949 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Speranza Chemical Co., Ltd. 		55
career henan chemical co 		58
Jinan Finer Chemical Co., Ltd 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
Shenzhen Excellent Biotech Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 2-Bromo-6-chlorobenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-6-chlorobenzoic acid pictures 2025-04-04 2-Bromo-6-chlorobenzoic acid
93224-85-2
 US $0.00 / KG 25KG 97% 1tone Henan Aochuang Chemical Co.,Ltd.
2-Bromo-6-chlorobenzoic acid pictures 2019-07-06 2-Bromo-6-chlorobenzoic acid
93224-85-2
 US $1.00 / kg 1kg 98% 200kg Career Henan Chemical Co

2-Bromo-6-chlorobenzoic acid Spectrum

2-Bromo-6-chlorobenzoic acid(93224-85-2)1HNMR

93224-85-2(2-Bromo-6-chlorobenzoic acid)Related Search:

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6-bromo-2-chloroBenzoic acid Benzoic acid, 2-broMo-6-chloro- 3-bromo-2-chloro-benzoic acid BUTTPARK 51\01-28 2-BROMO-6-CHLOROBENZOIC ACID AKOS MSC-0781 2-Bromo-6-chlorobenzoic acid ISO 9001：2015 REACH 2-Bromo-6-chlorobenzoicaci 2-Bromo-6-chlorobenzoic acid, CAS 93224-85-2 93224-85-2 936-08-5 C42H24Br6Cl6O12 C7H4BrClO2 Acids and Esters Acids & Esters Bromine Compounds Chlorine Compounds blocks Bromides Carboxes Benzoic acid API intermediates