ChemicalBook >> CAS DataBase List >>Zoledronic acid

Zoledronic acid

CAS No.
118072-93-8
Chemical Name:
Zoledronic acid
Synonyms
Zoledronic;ZOLEDRONATE;ZoMeta;Reclast;Zoledronic Acid API;Orazol;BPH 91;Aclasta;ZOL 446;CGP-4244
CBNumber:
CB4395643
Molecular Formula:
C5H10N2O7P2
Molecular Weight:
272.09
MDL Number:
MFCD00867791
MOL File:
118072-93-8.mol
Last updated:2023-08-15 17:37:19

Zoledronic acid Properties

Melting point 193-2040C (dec)
Boiling point 764.0±70.0 °C(Predicted)
Density 2.13±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in Water (up to 2 mg/ml).
form solid
pka 1.41±0.10(Predicted)
color White or off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
CAS DataBase Reference 118072-93-8(CAS DataBase Reference)
FDA UNII 70HZ18PH24
NCI Dictionary of Cancer Terms zoledronate; zoledronic acid; Zometa
NCI Drug Dictionary Orazol
ATC code M05BA08

Pharmacokinetic data

Protein binding 56%
Excreted unchanged in urine 39 +/- 16%
Volume of distribution 6.1-10.8 Litres
Biological half-life 146 / Increased

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  21/22-36/37/38
Safety Statements  24/25-36/37/39
HS Code  2933399090

Zoledronic acid price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 6111 Zoledronic Acid ≥98%(HPLC) 118072-93-8 10 $70 2021-12-16 Buy
Tocris 6111 Zoledronic Acid ≥98%(HPLC) 118072-93-8 50 $290 2021-12-16 Buy
TRC Z623505 Zoledronic Acid 118072-93-8 250mg $1065 2021-12-16 Buy
TRC Z623505 Zoledronic Acid 118072-93-8 5mg $75 2021-12-16 Buy
TRC Z623505 Zoledronic Acid 118072-93-8 25mg $215 2021-12-16 Buy
Product number Packaging Price Buy
6111 10 $70 Buy
6111 50 $290 Buy
Z623505 250mg $1065 Buy
Z623505 5mg $75 Buy
Z623505 25mg $215 Buy

Zoledronic acid Chemical Properties,Uses,Production

Description

Zoledronic acid is a white, crystalline powder that is available in vials for reconstitution for IV infusion over at least 15 minutes. It does not undergo metabolic transformation and does not inhibit CYP450 enzymes. Clearance of this agent is dependent on the patient's creatinine clearance, not on dose. Serum creatinine levels should be evaluated before every treatment. Zolendronic acid is contraindicated in patients with severe renal impairment.

Chemical Properties

White Solid

Originator

Zometa,Novartis Pharma,Switz

Uses

bone resorption inhibitor

Uses

Bisphosphonate antiresorptive agent

Uses

Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.

Definition

ChEBI: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.

Manufacturing Process

With stirring and under reflux, 8.6 g (0.053 mole) of imidazol-4-yl acetic acid hydrochloride, 7.1 ml of 85% phosphoric acid and 25 ml of chlorobenzene are heated to 100°C. Then 13.9 ml of phosphorus trichloride are added dropwise at 100°C, whereupon evolution of gas occurs. Over the course of 30 min a dense mass precipitates from the reaction mixture. The batch is heated for 3 hours to 100°C and the supernatant chlorobenzene is removed by decantation. With stirring and under reflux, the residual viscous mass is heated to the boil for 3 hours with 40 ml of 9 N hydrochloric acid. The batch is filtered hot with the addition of carbon and the filtrate is diluted with acetone, whereupon the crude 2-(imidazol-4-yl)-1-hydroxy-ethane-1,1- diphosphonic acid precipitates. This product is recrystallised from water. Melting point: 238-240°C (dec.).

brand name

Zometa (Novartis).

Therapeutic Function

Bone calcium regulator

Biological Functions

Zoledronic acid, a bisphosphonate, was approved by the U.S. FDA in 2001 for the treatment of hypercalcemia of malignancy, a metabolic complication that can be life-threatening. Hypercalcemia of malignancy can occur in up to 50% of patients diagnosed with advanced breast cancer, multiple myeloma, and nonsmall cell lung cancer. This condition arises when chemical moieties produced by the tumor cause overstimulation of osteoclasts. When there is an increase in bone degradation, there is a concomitant release of calcium into the plasma. When serum concentrations of calcium rapidly elevate, the kidneys are unable to handle the overload, and hypercalcemia results. This can lead to dehydration, nausea, vomiting, fatigue, and confusion. Zoledronic acid effectively decreases plasma calcium concentrations via inhibition of bone resorption (inhibition of osteoclastic activity and induction of osteoclast apoptosis). It also prevents the increase in osteoclastic activity caused by tumor-based stimulatory factors. Additionally zoledronic acid has been approved by the U.S. FDA for the treatment of multiple myeloma and bone metastases associated with solid tumor–based cancers (e.g., prostrate and lung). This agent is currently in late-stage clinical trials for the treatment and prevention of osteoporosis and, if approved, will be formulated as a 5-mg, once-yearly IV infusion.

Clinical Use

Zoledronic acid is most commonly given to patients whose cancer is no longer responding to hormones, but it also may be given to prevent the bone thinning and weakening that results from hormonal treatments.

Drug interactions

Potentially hazardous interactions with other drugs
Other nephrotoxic drugs: use with caution as can enhance nephrotoxicity

Metabolism

Zoledronic acid is not metabolised and is excreted unchanged via the kidney. Over the first 24 hours, 39 ± 16
% of the administered dose is recovered in the urine, while the remainder is principally bound to bone tissue.

storage

Store at +4°C

References

1) Green?et al. (1994),?Preclinical pharmacology of CGP 42446, a new, potent, heterocyclic bisphosphonate compound; J. Bone Miner. Res.,?9?745 2) Deeks and Perry (2008)?Zoledronic acid: a review of its use in the treatment of osteoporosis; Drugs Aging,?25?963 3) Perry and Figgitt (2004),?Zoledronic acid: a review of its use in patients with advanced cancer; Drugs,?64?1197 4) Koto?et al. (2010)?Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis and shows combined effects with other anticancer agents; Oncol. Rep.,?24?233 5) Tonyali?et al. (2010)?The role of zoledronic acid in the adjuvant treatment of breast cancer: current perspectives; Expert Opin. Pharmacother.,?11?2715

Zoledronic acid Preparation Products And Raw materials

Global( 454)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460 faith@widelychemical.com CHINA 742 58

View Lastest Price from Zoledronic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Zoledronic acid pictures 2023-08-15 Zoledronic acid
118072-93-8
US $50.00 / KG 1KG 99% 5000KG Hebei Mojin Biotechnology Co., Ltd
Zoledronic acid pictures 2023-06-20 Zoledronic acid
118072-93-8
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Zoledronic acid pictures 2023-04-11 Zoledronic acid
118072-93-8
US $0.00-0.00 / kg 1kg 98% 100kg Nanjing Kaitian Chemical Co., LTD
  • Zoledronic acid pictures
  • Zoledronic acid
    118072-93-8
  • US $50.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Zoledronic acid pictures
  • Zoledronic acid
    118072-93-8
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Zoledronic acid pictures
  • Zoledronic acid
    118072-93-8
  • US $0.00-0.00 / kg
  • 98%
  • Nanjing Kaitian Chemical Co., LTD

Zoledronic acid Spectrum

2-(imidazole-1-yl)-1-acetic acid HCl CGP-42446 sMall aMount Aclasta BPH 91 Orazol ZOL 446 1-HYDROXY-2-IMIDAZOLE-1-YLETHYLIDENE DIPHOSPHONIC ACID (1-Hydroxy-2-iMidazol-1-yl-1-phosphono-ethyl)-phosphonic acid Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- 1-hydroxy-2-(1H-iMidazol-1-yl)ethane-1,1-diyldiphosphonic acid [1-hydroxy-2-(1H-iMidazol-1-yl)-1-phosphonoethyl]phosphonic acid Zoledronic Acid(Zoledronate) Zoledronic acid SynonyMs [1-Hydroxy-2-(1H-iMidazol-1-yl)-ethylidene]bisphosphonic acid ZOLEDRONIC ACID [1-hydroxy-2-(1h-imidazol-1-yl)-ethylidene]bisphosphonic acid 2-(Imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic Acid CGP-4244 Zoledronate acid [1-HYDROXY-(1H-IMIDAZOL-1-YL)-PHOSPHONOETHYL] PHOSPHONIC ACI MONOHYDRATE 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid zoledronic acid price CGP 42446; ZOL 446 Zoledronic Acid (CGP 42446) Zoledronic acid monohydrate CRS Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- zoledronicaci Zoledronic acid-D5 Zoledronic acidQ: What is Zoledronic acid Q: What is the CAS Number of Zoledronic acid Q: What is the storage condition of Zoledronic acid Q: What are the applications of Zoledronic acid Zoledronic Acid (1724827) Cefalival Cefibacter Zoledronic Acid API Reclast ZoMeta ZOLEDRONATE Zoledronic Zolidronic Acid 118072-93-8 C5H10N2O7P C5H10N2O7P2 C5H10N2O7P2H2O TGF-beta/Smad APIs All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Zoledronic Zoledronate Smad TGF-beta Antiosteoporotic Pharmaceutical material and intermeidates Bone resorption inhibitor 118072-93-8