ChemicalBook >> CAS DataBase List >>Ropivacaine


Chemical Name:
Naropin;ROPIVACAINE MESYLATER;RopivacaineHcl/MesylateBase;(S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide;Seduron;Naropine;ROPIVACAINE;MesylateBase;S-ROPIVACAINE;ROPACARAINEHCL
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2023-11-02 11:53:15

Ropivacaine Properties

Melting point 144-146°
alpha D25 -82.0° (c = 2 in methanol)
Boiling point 410.2±45.0 °C(Predicted)
Density 1.044±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Aqueous Acid (Slightly), Chloroform (Slightly), DMSO (Slightly)
form Solid
pka 8.16(at 25℃)
color White to Off-White
CAS DataBase Reference 84057-95-4(CAS DataBase Reference)
NCI Dictionary of Cancer Terms Naropin
NCI Drug Dictionary Naropin
ATC code N01BB09


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H336-H370
Precautionary statements  P260-P264-P270-P271-P304+P340+P312-P308+P311
HS Code  2933399090

Ropivacaine price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2571 Ropivacaine 84057-95-4 500MG $210 2022-05-15 Buy
Sigma-Aldrich 1605497 Ropivacaine 84057-95-4 200mg $421 2022-05-15 Buy
Alfa Aesar H37974 Ropivacaine 97% 84057-95-4 250mg $59.1 2023-06-20 Buy
Alfa Aesar H37974 Ropivacaine 97% 84057-95-4 1g $151 2023-06-20 Buy
Alfa Aesar H37974 Ropivacaine 97% 84057-95-4 5g $520 2023-06-20 Buy
Product number Packaging Price Buy
PHR2571 500MG $210 Buy
1605497 200mg $421 Buy
H37974 250mg $59.1 Buy
H37974 1g $151 Buy
H37974 5g $520 Buy

Ropivacaine Chemical Properties,Uses,Production


Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. Naropin was launched in 1996 in Australia, Denmark, Finland, the Netherlands and Sweden as a local anesthetic. It can be prepared in a number of ways the most efficient involves a three step sequence beginning with L-pipecolic acid. This compound is the first one in this family to be produced as the pure (S)- enantiomer. The (R)-enantiomer has been shown to have cardiotoxic effects. Thus ropivicaine has less cardiovascular and CNS toxicity than bupivacaine. It is a Na channel blocker that is specific for affecting nerve fibers responsible for transmission of pain (Aδ and C) with no effect on fibers responsible for motor function (Aβ). Clinically, it has distinct advantages over bupivacaine. Its effects are slower in onset, less intense and have a shorter duration. This is a result of extensive metabolism in the liver to the 3-hydroxy isomer by CYPIA2 isoenzyme.
Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.
Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains.


Astra (Sweden)


(S)-Ropivacaine acts as a local anaesthetic for use during medical procedures. Frequently used in epidural procedures as a labor analgesia


Ropivacaine is a pure S(-)-enantiomer of propivacaine. It is a long-acting amide local anesthetic that has efficacy and potency nearly as high as bupivacaine and levobupivacaine but has lower CNS and cvS toxicity. If there are any differences between bupivacaine and ropivacaine it is the slightly shorter period of activity in spinal and epidural applications and a lowered ability to penetrate large motor nerves. It is the reduced lipophilicity that contributed to the lowered penetration of the motor nerves, combined with its stereoselective properties that allows ropivacaine to have significantly reduced Cvs toxicity compared to bupivacaine (Simpson et al. 2005). Ropivacaine has a diphasic effect on peripheral vasculature-it is vasoconstrictive when injected at a concentration below 0.5 w/v% and there is dilation at concentrations over 1 w/v% (Cederholm et al. 1992).
Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.


ChEBI: A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.

brand name

Narapin [as hydrochloride] (Astra).

Biological Functions

Ropivacaine (Naropin) is a recently developed longacting amide-linked local anesthetic. Its duration of action is similar to that of bupivacaine, but it is slightly less potent and requires higher concentrations to achieve the same degree of block. Its primary advantage over bupivacaine is its lesser degree of cardiotoxicity.

General Description

The recognized increase in cardiotoxicity of one bupivacaineisomer led to the stereospecific production of ropivacaine asthe single “S” (-) enantiomer. Ropivacaine is the propylanalog of mepivacaine (methyl) and bupivacaine (butyl). ThepKa of the tertiary nitrogen is 8.1, and it displays the same degreeof protein binding as bupivacaine ( 94%). Althoughropivacaine has similar properties as bupivacaine, it displaysless cardiotoxicity. The shortened alkyl chain gives it approximatelyone third of the lipid solubility of bupivacaine.

Mechanism of action

Ropivacaine is a member of the amino amide class of local anesthetics and is supplied as the pure S-(- )-enantiomer. Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone.


This is a single (S–) enantiomer, similar in structure to bupivacaine. S ubstitution of a propyl for the butyl side chain of bupivacaine reduces lipid solubility; this leads to reduced potential for toxicity and also greater separation between sensory and motor blockade. Efficacy is similar, but motor block is reduced compared with equianalgesic doses of racemic bupivacaine.

Clinical Use

Ropivacaine is a long-acting amide-type local anestheticwith inherent vasoconstrictor activities, so it does not requirethe use of additional vasoconstrictors. It is approved forepidural, nerve block, infiltration, and intrathecal anesthesia.

Side effects

Reactions to ropivacaine are characteristic of those associated with other amide-type local anesthetics. A major cause of adverse reactions to this group of drugs may be associated with excessive plasma levels, which may be due to overdosage, unintentional intravascular injection or slow metabolic degradation.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Blurred vision
chest pain or discomfort
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
lightheadedness, dizziness, or fainting
slow or irregular heartbeat
unusual tiredness or weakness
Less common
Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
decrease in frequency or amount of urine
difficulty in passing urine (dribbling)
painful urination
Absence of or decrease in body movement


The metabolism of ropivacaine in human is mediated by hepatic CYP1A2 isozymes and, to a minor extent, by CYP3A4. The major metabolite is 3-hydroxyropivacaine, and the minor metabolite is (S)-2′,6′-pipecoloxylidide (a N-dealkylated product).
Ropivacaine is extensively metabolized in the liver, predominantly by aromatic hydroxylation mediated by cytochrome P4501A to 3-hydroxyropivacaine. After a single IV dose approximately 37% of the total dose is excreted in the urine as both free and conjugated 3-hydroxy ropivacaine. Low concentrations of 3-hydroxy ropivacaine have been found in the plasma. Urinary excretion of the 4-hydroxy ropivacaine, and both the 3-hydroxy N-de-alkylated (3-OH-PPX) and 4-hydroxy N-dealkylated (4-OH-PPX) metabolites account for less than 3% of the dose. An additional metabolite, 2- hydroxy-methyl-ropivacaine, has been identified but not quantified in the urine. The N-de-alkylated metabolite of ropivacaine (PPX) and 3-OH-ropivacaine are the major metabolites excreted in the urine during epidural infusion. Total PPX concentration in the plasma was about half as that of total ropivacaine; however, mean unbound concentrations of PPX were about 7 to 9 times higher than that of unbound ropivacaine following continuous epidural infusion up to 72 hours. Unbound PPX, 3- hydroxy and 4-hydroxy ropivacaine, have a pharmacological activity in animal models less than that of ropivacaine. There is no evidence of in vivo racemization in urine of ropivacaine.

Synthesis of Ropivacaine from 1-Bromopropane and (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide)

Ropivacaine Preparation Products And Raw materials

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ropivacaine pictures 2023-12-07 Ropivacaine
US $120.00 / KG 1250KG 99.8% 330T Xiamen Wonderful Bio Technology Co., Ltd.
Ropivacaine pictures 2023-12-07 Ropivacaine
US $18.00 / KG 1KG 99% 100000T Xiamen Wonderful Bio Technology Co., Ltd.
Ropivacaine;(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide pictures 2023-12-07 Ropivacaine;(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide
US $15.00 / KG 1KG 99% large quantity Xiamen Wonderful Bio Technology Co., Ltd.
  • Ropivacaine pictures
  • Ropivacaine
  • US $120.00 / KG
  • 99.8%
  • Xiamen Wonderful Bio Technology Co., Ltd.
  • Ropivacaine pictures
  • Ropivacaine
  • US $18.00 / KG
  • 99%
  • Xiamen Wonderful Bio Technology Co., Ltd.

Ropivacaine Spectrum

ROPACARAINEHCL (S)-N-(2,6-Dimethylphenyl)-1-pKIpyl-2-piperidinecarboxamide 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)- Naropine (2S)-1-Propyl-2-(2,6-dimethylphenyl)carbamoylpiperidine (2S)-1-Propyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Ropivacainebase Ropivacaine (200 mg) Ropivacaine API Ropivacaine HCl (base) (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide (2S)-N-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide Ropivacaine Free base (2r,2'r,3r,3'r,4r)-2,2'-bis(3,4-dihydroxyphenyl)-5,5',7,7'-tetrahydroxy-3,3',4,4'-tetrahydro-2h,2'h-4,8'-bichromene-3,3'-diyl bis(3,4,5-trihydroxybenzoate) S-ROPIVACAINE ROPIVACAINE n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide Ropivacaine HCl 84057-95-4 ROPIVACAINE CAS NO:84057-95-4 MesylateBase ROM. Pp because Ropivacaine USP/EP/BP RopivacaineQ: What is Ropivacaine Q: What is the CAS Number of Ropivacaine Q: What is the storage condition of Ropivacaine Q: What are the applications of Ropivacaine Ropivacaine (1605497) Ropivacaine Base With Seduron ROPIVACAINE MESYLATER RopivacaineHcl/MesylateBase Naropin (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide Ziresovir Impurity 3 84057-95-4 98717-15-9 84057-95-7 C17H26N2O API