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Ropivacaine structure
Chemical Name:
Naropin;Naropine;ROPIVACAINE;S-ROPIVACAINE;ROPACARAINEHCL;Ropivacainebase;Ropivacaine API;Ropivacaine (200 mg);ROPIVACAINE MESYLATER;Ropivacaine Free base
Molecular Formula:
Formula Weight:
MOL File:

Ropivacaine Properties

Melting point:
D25 -82.0° (c = 2 in methanol)
8.16(at 25℃)
CAS DataBase Reference
84057-95-4(CAS DataBase Reference)
  • Risk and Safety Statements
HS Code  2933399090

Ropivacaine price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1605497 Ropivacaine 200mg $352.8 2018-11-20 Buy
Alfa Aesar H37974 Ropivacaine 97% 84057-95-4 250mg $54.9 2018-11-20 Buy
Alfa Aesar H37974 Ropivacaine 97% 84057-95-4 1g $145 2018-11-20 Buy
Alfa Aesar H37974 Ropivacaine 97% 84057-95-4 5g $505 2018-11-20 Buy

Ropivacaine Chemical Properties,Uses,Production


Naropin was launched in 1996 in Australia, Denmark, Finland, the Netherlands and Sweden as a local anesthetic. It can be prepared in a number of ways the most efficient involves a three step sequence beginning with L-pipecolic acid. This compound is the first one in this family to be produced as the pure (S)- enantiomer. The (R)-enantiomer has been shown to have cardiotoxic effects. Thus ropivicaine has less cardiovascular and CNS toxicity than bupivacaine. It is a Na channel blocker that is specific for affecting nerve fibers responsible for transmission of pain (Aδ and C) with no effect on fibers responsible for motor function (Aβ). Clinically, it has distinct advantages over bupivacaine. Its effects are slower in onset, less intense and have a shorter duration. This is a result of extensive metabolism in the liver to the 3-hydroxy isomer by CYPIA2 isoenzyme.


Astra (Sweden)


Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. - See more at:


ChEBI: A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.

brand name

Narapin [as hydrochloride] (Astra).

Biological Functions

Ropivacaine (Naropin) is a recently developed longacting amide-linked local anesthetic. Its duration of action is similar to that of bupivacaine, but it is slightly less potent and requires higher concentrations to achieve the same degree of block. Its primary advantage over bupivacaine is its lesser degree of cardiotoxicity.

General Description

The recognized increase in cardiotoxicity of one bupivacaineisomer led to the stereospecific production of ropivacaine asthe single “S” (-) enantiomer. Ropivacaine is the propylanalog of mepivacaine (methyl) and bupivacaine (butyl). ThepKa of the tertiary nitrogen is 8.1, and it displays the same degreeof protein binding as bupivacaine ( 94%). Althoughropivacaine has similar properties as bupivacaine, it displaysless cardiotoxicity. The shortened alkyl chain gives it approximatelyone third of the lipid solubility of bupivacaine.

Clinical Use

Ropivacaine is a long-acting amide-type local anestheticwith inherent vasoconstrictor activities, so it does not requirethe use of additional vasoconstrictors. It is approved forepidural, nerve block, infiltration, and intrathecal anesthesia.

Ropivacaine Preparation Products And Raw materials

Raw materials

Preparation Products

Ropivacaine Suppliers

Global( 142)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897093 CHINA 146 58
Hebei Chisure Biotechnology Co., Ltd.
0311 66567340 CHINA 1018 58
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 535 55
career henan chemical co
+86-371-86658258 CHINA 29979 58
Hebei Ruishun Trade Co.,LTD
17052563120 CHINA 302 58
Anhui Dexinjia Biopharm Co., Ltd
86-531-82375893 CHINA 129 58
Jinan Jianfeng Chemical Co., Ltd
15562555968 CHINA 294 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23978 58

View Lastest Price from Ropivacaine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-21 Ropivacaine
US $1.00 / KG 1G 98% 100KG career henan chemical co
2019-04-26 Ropivacaine
US $10.00 / kg 1kg 99% 500tons/month Hebei Chisure Biotechnology Co., Ltd.
2018-03-14 Ropivacaine HCl 84057-95-4
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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