Dicloxacillin sodium
- CAS No.
- 13412-64-1
- Chemical Name:
- Dicloxacillin sodium
- Synonyms
- Dicloxacillin sodium;Dicloxacillin sodium CRS;Dicloxacillin Sodium (500 mg);Dicloxacillin Sodium (300 mg);icloxacillinsodiummonohydrate;Dicloxacillin sodium USP/EP/BP;Dicloxacillin Sodium (1189009);DICLOXACILLIN SODIUM WHO(CRM STANDARD);DICLOXACILLIN SODIUM USP(CRM STANDARD);DICLOXACILLIN SODIUM EPD(CRM STANDARD)
- CBNumber:
- CB4679268
- Molecular Formula:
- C19H20Cl2N3NaO6S
- Molecular Weight:
- 512.33
- MDL Number:
- MFCD00167147
- MOL File:
- 13412-64-1.mol
| Melting point | 222-225°C |
|---|---|
| alpha | D20 +127.2° (water) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble50mg/mL |
| form | powder |
| color | white to off-white |
| Water Solubility | Soluble in water |
| BRN | 4778711 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 13412-64-1(CAS DataBase Reference) |
| FDA UNII | 4HZT2V9KX0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 22-26-36/37-45 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XH8925000 | |||||||||
| HS Code | 29411099 | |||||||||
| Toxicity | LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; >5 orally (Gloxhuber) | |||||||||
| NFPA 704 |
|
Dicloxacillin sodium price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 46182 | Dicloxacillin sodium salt hydrate VETRANAL | 13412-64-1 | 100mg | $59.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1189009 | Dicloxacillin sodium United States Pharmacopeia (USP) Reference Standard | 13412-64-1 | 300mg | $436 | 2024-03-01 | Buy |
| Alfa Aesar | J61581 | Dicloxacillin sodium salt monohydrate | 13412-64-1 | 1g | $73.4 | 2024-03-01 | Buy |
| Alfa Aesar | J61581 | Dicloxacillin sodium salt monohydrate | 13412-64-1 | 5g | $197.65 | 2024-03-01 | Buy |
| Cayman Chemical | 23770 | Dicloxacillin (sodium salt hydrate) ≥98% | 13412-64-1 | 1g | $57 | 2024-03-01 | Buy |
Dicloxacillin sodium Chemical Properties,Uses,Production
Brand Name(s) in US
Dynapen
Chemical Properties
White to off-white crystalline powder
Originator
Dynapen,Bristol,US,1968
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Uses
A semi-synthetic antibiotic related to Penicillin. Antibacterial.
Uses
Dicloxacillin sodium salt is used in the treatment of staphylococci resistant to penicillin G. Dicloxacillin binds to specific penicillin-binding proteins in the bacterial cell wall and therefore inhibits the last stage of bacterial cell wall synthesis. Cell lysis, mediated by bacterial cell wall autolytic enzymes, is the result. Dicloxacillin may interfere with autolysin inhibitors.
Definition
ChEBI: Dicloxacillin sodium monohydrate is a hydrate. It contains a dicloxacillin sodium.
Manufacturing Process
A suspension of 6-aminopenicillanic acid (216 grams) in water (2 liters) was
adjusted to pH 6.8 by the addition of N aqueous sodium hydroxide
(approximately 1 liter) and the resulting solution was stirred vigorously while
a solution of 3-(2',6'-dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride
(290 grams) in acetone (1.5 liters) was added in one portion.
The temperature rose to 26°C and as reaction proceeded the free acid form of
the penicillin separated as a white solid. After 30 minutes the suspension was
cooled to 10°C and stirring was continued at this temperature for 1 hour
more. The mixture was then cooled to 0°C, centrifuged, and the solid product
washed with aqueous acetone (250 ml) and finally dried in an air oven at
30°C. The product (440 grams, 94%) had [α]D20 +106.3° (c 1 in EtOH) and
was shown by alkalimetric assay to be 97.5% pure.
The salt was prepared by dissolving the free acid form of the penicillin in the
equivalent amount of aqueous sodium bicarbonate and freeze drying the
resulting solution. The hydrated salt so obtained was shown by alkalimetric
assay to be 94% pure and to contain 6% water.
brand name
Dynapen (Apothecon).
Therapeutic Function
Antibacterial
General Description
The substitution of chlorine atoms on both carbons orthoto the position of attachment of the phenyl ring to the isoxazolering is presumed to enhance further the stability ofthe oxacillin congener dicloxacillin sodium, [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodiummonohydrate (Dynapen, Pathocil, Veracillin) and toproduce high plasma concentrations of it. Its medicinalproperties and use are similar to those of cloxacillinsodium. Progressive halogen substitution, however, alsoincreases the fraction bound to protein in the plasma, potentiallyreducing the concentration of free antibiotic inplasma and tissues. Its medicinal properties and use are thesame as those of cloxacillin sodium.
Veterinary Drugs and Treatments
The veterinary use of dicloxacillin has been primarily in the PO treatment of bone, skin, and other soft tissue infections in small animals when penicillinase-producing Staphylococcus species have been isolated. Because of its low oral bioavailability and short halflife, other drugs with good staph coverage are usually employed.
Dicloxacillin sodium Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3586 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9358 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
View Lastest Price from Dicloxacillin sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-01 | Dicloxacillin sodium
13412-64-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-04-08 | Dicloxacillin sodium
13412-64-1
|
US $56.00 / kg | 1kg | 99% | 5000 tons | Hebei Duling International Trade Co. LTD | |
 |
2021-07-09 | Dicloxacillin sodium
13412-64-1
|
US $10.00 / KG | 100KG | 99% | 100 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Dicloxacillin sodium
13412-64-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Dicloxacillin sodium
13412-64-1
- US $56.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- Dicloxacillin sodium
13412-64-1
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.