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Dicloxacillin sodium

Brand Name(s) in US
Dicloxacillin sodium
Dicloxacillin sodium structure
CAS No.
13412-64-1
Chemical Name:
Dicloxacillin sodium
Synonyms
Dicloxacillin sodium;Dicloxacillin sodium CRS;Dicloxacillin Sodium (500 mg);Dicloxacillin Sodium (300 mg);icloxacillinsodiummonohydrate;Dicloxacillin sodium USP/EP/BP;DICLOXACILLIN SODIUM WHO(CRM STANDARD);DICLOXACILLIN SODIUM USP(CRM STANDARD);DICLOXACILLIN SODIUM EPD(CRM STANDARD);DICLOXACILLIN SODIUM SALT HYDRATE VETRAN
CBNumber:
CB4679268
Molecular Formula:
C19H16Cl2N3NaO5S·H2O
Formula Weight:
510.32
MOL File:
13412-64-1.mol

Dicloxacillin sodium Properties

Melting point:
222-225°C
alpha 
D20 +127.2° (water)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL
form 
powder
color 
white to off-white
Water Solubility 
Soluble in water
BRN 
4778711
CAS DataBase Reference
13412-64-1(CAS DataBase Reference)
FDA UNII
4HZT2V9KX0
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H319-H334-H335-H303-H317
Precautionary statements  P280a-P405-P501a-P261-P284-P304+P340-P305+P351+P338-P342+P311
Hazard Codes  Xn
Risk Statements  36/37/38-42/43
Safety Statements  22-26-36/37-45
WGK Germany  2
RTECS  XH8925000
HS Code  29411099
Toxicity LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; >5 orally (Gloxhuber)

Dicloxacillin sodium price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46182 Dicloxacillin sodium salt hydrate VETRANAL 13412-64-1 100mg $44.3 2019-12-02 Buy
Sigma-Aldrich D1050000 Dicloxacillin sodium European Pharmacopoeia (EP) Reference Standard 13412-64-1 $190 2021-03-22 Buy
Sigma-Aldrich 1189009 Dicloxacillin sodium United States Pharmacopeia (USP) Reference Standard 13412-64-1 300mg $366 2021-03-22 Buy
Alfa Aesar J61581 Dicloxacillin sodium salt monohydrate 13412-64-1 5g $191 2020-06-24 Buy
Alfa Aesar J61581 Dicloxacillin sodium salt monohydrate 13412-64-1 1g $59.8 2020-06-24 Buy

Dicloxacillin sodium Chemical Properties,Uses,Production

Brand Name(s) in US

Dynapen

Chemical Properties

White to off-white crystalline powder

Originator

Dynapen,Bristol,US,1968

Uses

A semi-synthetic antibiotic related to Penicillin. Antibacterial.

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Manufacturing Process

A suspension of 6-aminopenicillanic acid (216 grams) in water (2 liters) was adjusted to pH 6.8 by the addition of N aqueous sodium hydroxide (approximately 1 liter) and the resulting solution was stirred vigorously while a solution of 3-(2',6'-dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride (290 grams) in acetone (1.5 liters) was added in one portion.
The temperature rose to 26°C and as reaction proceeded the free acid form of the penicillin separated as a white solid. After 30 minutes the suspension was cooled to 10°C and stirring was continued at this temperature for 1 hour more. The mixture was then cooled to 0°C, centrifuged, and the solid product washed with aqueous acetone (250 ml) and finally dried in an air oven at 30°C. The product (440 grams, 94%) had [α]D20 +106.3° (c 1 in EtOH) and was shown by alkalimetric assay to be 97.5% pure.
The salt was prepared by dissolving the free acid form of the penicillin in the equivalent amount of aqueous sodium bicarbonate and freeze drying the resulting solution. The hydrated salt so obtained was shown by alkalimetric assay to be 94% pure and to contain 6% water.

brand name

Dynapen (Apothecon).

Therapeutic Function

Antibacterial

General Description

The substitution of chlorine atoms on both carbons orthoto the position of attachment of the phenyl ring to the isoxazolering is presumed to enhance further the stability ofthe oxacillin congener dicloxacillin sodium, [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodiummonohydrate (Dynapen, Pathocil, Veracillin) and toproduce high plasma concentrations of it. Its medicinalproperties and use are similar to those of cloxacillinsodium. Progressive halogen substitution, however, alsoincreases the fraction bound to protein in the plasma, potentiallyreducing the concentration of free antibiotic inplasma and tissues. Its medicinal properties and use are thesame as those of cloxacillin sodium.

Veterinary Drugs and Treatments

The veterinary use of dicloxacillin has been primarily in the PO treatment of bone, skin, and other soft tissue infections in small animals when penicillinase-producing Staphylococcus species have been isolated. Because of its low oral bioavailability and short halflife, other drugs with good staph coverage are usually employed.

Dicloxacillin sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Dicloxacillin sodium Suppliers

Global( 160)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
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Guangzhou PI PI Biotech Inc
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Hebei Guanlang Biotechnology Co., Ltd.
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sales3@crovellbio.com China 5930 58
CONIER CHEM AND PHARMA LIMITED
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Target Molecule Corp
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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View Lastest Price from Dicloxacillin sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 Dicloxacillin sodium
13412-64-1
US $5.00 / KG 1KG 99% 100 TONS Wuhan wingroup Pharmaceutical Co., Ltd
2021-07-09 Dicloxacillin sodium
13412-64-1
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-06-25 Dicloxacillin sodium USP/EP/BP
13412-64-1
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

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