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1,4-Dihydroxynaphthalene

CAS No.
571-60-8
Chemical Name:
1,4-Dihydroxynaphthalene
Synonyms
NAPHTHALENE-1,4-DIOL;1,4-NAPHTHALENEDIOL;1,4-NDO;1.4-Dihydroxyn;1,4-naphthoquinol;1,4-NAPTHALENEDIOL;Hydronaphthoquinone;Naphthohydroquinone;Naphthalin-1,4-diol;1,4-Naphththalenediol
CBNumber:
CB4756341
Molecular Formula:
C10H8O2
Molecular Weight:
160.17
MDL Number:
MFCD00003977
MOL File:
571-60-8.mol
MSDS File:
SDS
Last updated:2026-05-28 02:16:50
Product description Number Pack Size Price
1,4-Dihydroxynaphthalene technical, ≥90% (HPLC) 70430 10g $172
1,4-Dihydroxynaphthalene >97.0%(GC)(T) D0589 5g $117
1,4-Dihydroxynaphthalene >97.0%(GC)(T) D0589 25g $353
Naphthohydroquinone ≥98% CS-0197295 5g $35
Naphthohydroquinone ≥98% CS-0197295 25g $78
More product size

1,4-Dihydroxynaphthalene Properties

Melting point 191-192 °C (dec.)
Boiling point 246.06°C (rough estimate)
Density 1.0924 (rough estimate)
refractive index 1.5178 (estimate)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form crystals
pka pK1:9.37;pK2:10.93 (26°C,μ=0.65)
color Grey
Water Solubility slightly soluble
BRN 1307689
InChI 1S/C10H8O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,11-12H
InChIKey PCILLCXFKWDRMK-UHFFFAOYSA-N
SMILES Oc1ccc(O)c2ccccc12
CAS DataBase Reference 571-60-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII AML1P6T42C
NIST Chemistry Reference 1,4-Naphthalenediol(571-60-8)
EPA Substance Registry System 1,4-Naphthalenediol (571-60-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335-H412
Precautionary statements  P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,T
Risk Statements  22-37/38-41-43-36/37/38-25
Safety Statements  26-39-45-36/37/39-28A-24
WGK Germany  3
RTECS  QJ4730000
8-10-16-23
TSCA  TSCA listed
HS Code  2921450090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

1,4-Dihydroxynaphthalene price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 70430 1,4-Dihydroxynaphthalene technical, ≥90% (HPLC) 571-60-8 10g $172 2026-04-30 Buy
TCI Chemical D0589 1,4-Dihydroxynaphthalene >97.0%(GC)(T) 571-60-8 5g $117 2026-04-30 Buy
TCI Chemical D0589 1,4-Dihydroxynaphthalene >97.0%(GC)(T) 571-60-8 25g $353 2026-04-30 Buy
ChemScene CS-0197295 Naphthohydroquinone ≥98% 571-60-8 5g $35 2026-06-04 Buy
ChemScene CS-0197295 Naphthohydroquinone ≥98% 571-60-8 25g $78 2026-06-04 Buy
Product number Packaging Price Buy
70430 10g $172 Buy
D0589 5g $117 Buy
D0589 25g $353 Buy
CS-0197295 5g $35 Buy
CS-0197295 25g $78 Buy

1,4-Dihydroxynaphthalene Chemical Properties,Uses,Production

Chemical Properties

brown to greyish powder. 1,4-Naphthalenediol [571-60-8], mp 195℃, is synthesized by reduction of 1,4- naphthoquinone with sodium dithionite, or by hydrolysis of 4-amino-1-naphthol with 20 % sulfuric acid. It undergoes oxidation to give 1,4-naphthoquinone; amination to give 4-amino-1-naphthol; and methylation (MeOH – HCl) to give 4-methoxy-1-naphthol.

Uses

1,4-Dihydroxynaphthalene is frequently used in organic synthesis as a reagent. In particular, it is used in the synthesis of a pH independent and cell permeant fluorescent dye, a hydroxyl regioisomeric 3'',4''-benzorhodol, which can be used as a fluorescent chemosensor and biomarker for biological applications.

Definition

ChEBI: Naphthalene-1,4-diol is a naphthalenediol and a naphthohydroquinone.

Biological Activity

1,4-Dihydroxynaphthalene is a potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses.

References

[1] LAURIE S. TSURUDA   A. D J  Michael W Lamé. Formation of epoxide and quinone protein adducts in B6C3F1 mice treated with naphthalene, sulfate conjugate of 1,4-dihydroxynaphthalene and 1,4-naphthoquinone[J]. Archives of Toxicology, 1995, 69 6: 362-367. DOI:10.1007/s002040050185.

107-96-0
130-15-4
571-60-8
65726-66-1
Synthesis of 1,4-Dihydroxynaphthalene from 3-Mercaptopropionic acid and 1,4-Naphthoquinone
Global( 185)Suppliers
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Henan Fengda Chemical Co., Ltd
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View Lastest Price from 1,4-Dihydroxynaphthalene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-Dihydroxynaphthalene pictures 2026-05-26 1,4-Dihydroxynaphthalene
571-60-8
$31.00 97.10% 10g TargetMol Chemicals Inc.
1,4-Dihydroxynaphthalene pictures 2025-09-25 1,4-Dihydroxynaphthalene
571-60-8
$2.00-10.00 1KG 99% Henan Fengda Chemical Co., Ltd
	1,4-Dihydroxynaphthalene pictures 2020-01-01 1,4-Dihydroxynaphthalene
571-60-8
$1.00 1KG 95-99% 1ton Career Henan Chemical Co
1,4-NAPHTHOHYDROQUINONE 1,4-NAPTHALENEDIOL P-NAPHTHOHYDROQUINONE 1,4-DIHYDROXYNAPHTHALENE 1,4-NDO 1,4-Dihydroxynaphthalene, 95+% ALPHA-NAPHTHOHYDROQUINONE 1,4-dihydroxynaphthalene,1:1mixturewith1,4-naphthoquinone 1,4-naphthoquinol 1,4-Naphththalenediol alpha-naphthoquinhydrone Hydronaphthoquinone Naphthalenediol-(1,4) Naphthohydroquinone 1,4-DIHYDROXYNAPTHALENE 1,4-Naphthalenediol, p-Naphthohydroquinone (α) 1,4-Dihydroxynaphthalene, balance mainly 1,4-Naphthoquinone,92% 1,4-Dihydroxynaphthalene, balance mainly 1,4-Naphthoquinone, 92% Naphthalene-1,4-diol, 95%+ 1,4-Naphthalenediol alpha-Naphthohydroquinone 1.4-Dihydroxyn 1,4-Dihydroxynaphthalene, technical 1,4-Dihydroxynaphthalene > Naphthalin-1,4-diol 1,4-NAPHTHALENEDIOL Bifeprunox Impurity 10 1,4-Dihydroxynaphthalene (Naphthalene-1,4-diol) NAPHTHALENE-1,4-DIOL 571-60-8 132-86-6 Oxygen Compounds Polyols Organic Building Blocks Building Blocks Naphthalene derivatives Intermediates of Dyes and Pigments